Results 41 to 50 of about 339,146 (175)

Next-generation sequencing and immuno-informatics for designing a multi-epitope vaccine against HSV-1-induced uveitis

Frontiers in Immunology
BackgroundUveitis, characterized by intraocular inflammation, poses significant clinical challenges, often leading to vision impairment or blindness. Herpes Simplex Virus type 1 (HSV-1) is a major cause of virus-induced uveitis. This study aims to design
He Cao, Zhi Cao, Yue Han, Jing Shan
doaj   +1 more source

Health related effects of wheat varieties [PDF]

, 2020
Summarises the different effects wheat digestion has on human ...
Borgen, Anders
core  

Antigen-specific acquired immunity in human brucellosis: implications for diagnosis, prognosis, and vaccine development. [PDF]

, 2012
Brucella spp., are Gram negative bacteria that cause disease by growing within monocyte/macrophage lineage cells. Clinical manifestations of brucellosis are immune mediated, not due to bacterial virulence factors.
Alessandro eSette, Anthony P Cannella, Eduardo eGotuzzo, Joseph M Vinetz, Joseph M Vinetz, Li eLiang, Mayuko eSaito, Philip eFelgner, Renee M Tsolis   +8 more
core   +1 more source

Immunoproteomics Reveals Pathogen’s Antigens Involved in Homo sapiens–Histoplasma capsulatum Interaction and Specific Linear B-Cell Epitopes in Histoplasmosis

Frontiers in Cellular and Infection Microbiology, 2020
Histoplasmosis is one of the most frequent systemic mycosis in HIV patients. In these patients, histoplasmosis has high rates of morbidity/mortality if diagnosis and treatment are delayed.
Marcos Abreu Almeida, Rodrigo Almeida-Paes, Allan Jefferson Guimarães, Richard Hemmi Valente, Célia Maria de Almeida Soares, Rosely Maria Zancopé-Oliveira   +5 more
doaj   +1 more source

HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]

, 2009
Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
Miura, T., Brumme, C. J., Brockman, M. A., Brumme, Z. L., Pereyra, F., Block, B. L., Trocha, A., John, M., Mallal, S., Harrigan, P. R., Walker, B. D.   +10 more
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Revolutionizing the virulent protein Internalin a in Listeria monocytogenes and designing multi epitope-based vaccine via immunoinformatic approaches

CyTA - Journal of Food
This study addresses the crucial protein Internalin A in the development of a possible vaccination against Listeria monocytogenes. A meticulous in silico strategy was used which included physiochemical analysis, epitope prediction, and molecular ...
Tariq Aziz, Muhammad Naveed, Muhammad Aqib Shabbir, Khizra Jabeen, Athina S. Tzora, Eleftherios Bonos, Ioannis Skoufos, Metab Alharbi, Abdullah F Alasmari, Abdulrahman Alshammari   +9 more
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A Basic Molecular Analysis of the Diabetic Antigen GAD by Homology Modelling. Principles of the Method and Understanding of Antigenicity and Binding Sites

Pteridines, 2007
Functional specificity of a protein is linked to its structure. A growing section of bioinformatics deals with the prediction and visualization of protein 3D structures.
Wiltgen Marco, Tilz Gernot P.
doaj   +1 more source

BCEPS: A Web Server to Predict Linear B Cell Epitopes with Enhanced Immunogenicity and Cross-Reactivity

Cells, 2021
Prediction of linear B cell epitopes is of interest for the production of antigen-specific antibodies and the design of peptide-based vaccines. Here, we present BCEPS, a web server for predicting linear B cell epitopes tailored to select epitopes that ...
Alvaro Ras-Carmona, Hector F. Pelaez-Prestel, Esther M. Lafuente, Pedro A. Reche   +3 more
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Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]

, 1992
Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine, Baum, Casali, Chambers, Coppel, Coppel, Cram, Flannery, Fregeau, Fregeau, Fujikura, Fusey, Fussey, Gershwin, Gershwin, Griffin, Griffin, James, Kaplan, Kunicki, Larrick, Leung, Leung, Mackay, Mackay, Mathews, McNeilage, Okamoto, Pollack, Ramsden, Reeves, Reimer, Robbins, Rokeach, Rowley, Ruther, Salemuddin, Sturgess, Sudin, Surh, Surh, Surh, Surh, Tan, Uibo, Van de Water, Van de Water, Van de Water, Van de Water, Williams   +49 more
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CoronaVR: A Computational Resource and Analysis of Epitopes and Therapeutics for Severe Acute Respiratory Syndrome Coronavirus-2

Frontiers in Microbiology, 2020
In December 2019, the Chinese city of Wuhan was the center of origin of a pneumonia-like disease outbreak with an unknown causative pathogen. The CDC, China, managed to track the source of infection to a novel coronavirus (2019-nCoV; SARS-CoV-2) that ...
Amit Kumar Gupta, Md. Shoaib Khan, Shubham Choudhury, Adhip Mukhopadhyay, Adhip Mukhopadhyay, Sakshi, Sakshi, Amber Rastogi, Amber Rastogi, Anamika Thakur, Anamika Thakur, Pallawi Kumari, Manmeet Kaur, Shalu, Chanchal Saini, Vandna Sapehia, Barkha, Pradeep Kumar Patel, Kailash T. Bhamare, Manoj Kumar, Manoj Kumar   +20 more
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