Results 41 to 50 of about 505,722 (385)
Frontiers in Neurology, 2023 BackgroundThe detection of myelin oligodendrocyte glycoprotein autoantibodies (MOG-Ab) is essential for the diagnosis of MOG-Ab-associated disease (MOGAD). The clinical implications of different epitopes recognized by MOG-Ab are largely unknown.
Jin Myoung Seok +13 more
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Phage display selection of HIV specific conserved mimotopes with IgG from long-term non-progressors [PDF]
, 2005 Poster presentation Background The aim of this study is to identify conserved epitopes of HIV-1 neutralizing antibodies in polyclonal plasma from LTNP to finally derive vaccine candidates.
Antoni, Sascha +6 more
core +1 more source
Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
Nature Biotechnology, 2019 Predictions of epitopes presented by class II human leukocyte antigen molecules (HLA-II) have limited accuracy, restricting vaccine and therapy design.
Julien Racle +11 more
semanticscholar +1 more source
Finding Epitopes with Computers
Chemistry & Biology, 2013 The goal of structural vaccinology is to enable the design and engineering of improved antigens. In a recent issue of Chemistry & Biology, Gourlay and colleagues provided evidence that structure-based computational methods allow prediction of B cell epitopes, a crucial step for antigen selection and optimization in vaccine development.
Rino Rappuoli, Enrico Malito
openaire +3 more sources
Journal of Pharmacological Sciences, 2007 The prevailing methods to predict T-cell epitopes are reviewed. Motif matching, matrix, support vector machine (SVM), and empirical scoring function methods are mainly reviewed; and the thermodynamic integration (TI) method using all-atom molecular dynamics (MD) simulation is mentioned briefly.
Takuya Takahashi, Hiromichi Tsurui
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Defining the epichromatin epitope [PDF]
Nucleus, 2017 Epichromatin is identified by immunostaining fixed and permeabilized cells with particular bivalent anti-nucleosome antibodies (mAbs PL2-6 and 1H6). During interphase, epichromatin resides adjacent to the inner nuclear membrane; during mitosis, at the outer surface of mitotic chromosomes.
Travis J. Gould +6 more
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Pteridines, 2007 Functional specificity of a protein is linked to its structure. A growing section of bioinformatics deals with the prediction and visualization of protein 3D structures.
Wiltgen Marco, Tilz Gernot P.
doaj +1 more source
Frontiers in Immunology, 2023 The devastating COVID-19 pandemic caused by SARS-CoV-2 and multiple variants or subvariants remains an ongoing global challenge. SARS-CoV-2-specific T cell responses play a critical role in early virus clearance, disease severity control, limiting the ...
Gang Yang +15 more
doaj +1 more source
Molecular mimicry, genetic homology, and gene sharing proteomic “molecular fingerprints” using an EBV (Epstein-Barr virus)-derived microarray as a potential diagnostic method in autoimmune disease [PDF]
, 2018 EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human
Alessandra Farina, Giuseppina +2 more
core +1 more source
PLoS Comput. Biol., 2014 Since its identification in 1983, HIV-1 has been the focus of a research effort unprecedented in scope and difficulty, whose ultimate goals — a cure and a vaccine – remain elusive.
B. Murrell +6 more
semanticscholar +1 more source