Results 41 to 50 of about 491,390 (408)

Alpha-fetoprotein is an autoantigen in hepatocellular carcinoma and juvenile Batten disease

Frontiers in Bioscience-Landmark, 2020
Failure of immune tolerance leads to production of autoantibodies to self-antigens. The repertoire of autoantibodies detected in cancer patients can indicate the presence of autoimmune disease.
Roberto Bei, Gerald J. Mizejewski
doaj   +1 more source

Computational Prediction of B-cell Epitopes of Mycobacterium tuberculosis-Implications in Vaccine Design

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021
Introduction: Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis. Bacillus Calmette-Guérin is the only vaccine available for TB.
Esakkimuthu THANGAMARIAPPAN, Manikandan MOHAN, Krishnan SUNDAR   +2 more
doaj   +1 more source

T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: A Comprehensive Update and Reappraisal

Diabetes, 2020
The autoimmune disease type 1 diabetes is characterized by effector T-cell responses to pancreatic β-cell–derived peptides presented by HLA class I and class II molecules, leading ultimately to β-cell demise and insulin insufficiency.
E. James, R. Mallone, S. Kent, T. DiLorenzo   +3 more
semanticscholar   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Yu, X.G., O'Sullivan, K.M., Lichterfeld, M., Le Gall, S., John, M., Mothe, B.R., Lee, P.K., Kalife, E.T., Cohen, D.E., Freedberg, K.A., Strick, D.A., Johnston, M.N., Sette, A., Rosenberg, E.S., Mallal, S.A., Goulder, P.J.R., Brander, C., Walker, B.D.   +19 more
core   +2 more sources

Phage display selection of HIV specific conserved mimotopes with IgG from long-term non-progressors [PDF]

, 2005
Poster presentation Background The aim of this study is to identify conserved epitopes of HIV-1 neutralizing antibodies in polyclonal plasma from LTNP to finally derive vaccine candidates.
Antoni, Sascha, Dietrich, Ursula, Dittmar, Matthias, Humber, Michael, Rodes, Berta, Schreiber, Andreas, Soriano, Vicente   +6 more
core   +1 more source

Schistosoma mansoni SmKI-1 or Its C-Terminal Fragment Induces Partial Protection Against S. mansoni Infection in Mice

Frontiers in Immunology, 2018
Current schistosomiasis control strategies are mainly based on chemotherapy, but the development of a vaccine against this parasitic disease would contribute to a long-lasting decrease in disease spectrum and transmission.
Suellen B. Morais, Suellen B. Morais, Barbara C. Figueiredo, Barbara C. Figueiredo, Barbara C. Figueiredo, Natan R. G. Assis, Natan R. G. Assis, Jane Homan, Fábio S. Mambelli, Rodrigo M. Bicalho, Cláudia Souza, Vicente P. Martins, Carina S. Pinheiro, Sergio C. Oliveira, Sergio C. Oliveira   +14 more
doaj   +1 more source

Preparation and Identification of a Monoclonal Antibody against the Pseudorabies Virus gE Glycoprotein through a Novel Strategy

Veterinary Sciences, 2023
Since 2011, pseudorabies virus (PRV) has recurred in several vaccinated pig farms in China. PRV variants with high virulence were found to be the main cause of the outbreaks.
Zhenyang Guo, Siyu Zhang, Hu Xu, Wansheng Li, Chao Li, Jing Zhao, Bangjun Gong, Qi Sun, Lirun Xiang, Hongyuan Zhao, Qian Wang, Guohui Zhou, Yandong Tang, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng   +17 more
doaj   +1 more source

Quantitative Prediction of Linear B-Cell Epitopes [PDF]

Biomedical Statistics and Informatics. Vol. 2, No.1, 2017, pp.1-3, 2017
In scientific literature, there are many programs that predict linear B-cell epitopes from a protein sequence. Each program generates multiple B-cell epitopes that can be individually studied. This paper defines a function called that combines results from five different prediction programs concerning the linear B-cell epitopes (ie., BebiPred ...
arxiv   +1 more source

Critical review of conformational B-cell epitope prediction methods [PDF]

Briefings in Bioinformatics, bbac567, 1-9, 2023, 2023
Accurate in-silico prediction of conformational B-cell epitopes would lead to major improvements in disease diagnostics, drug design and vaccine development. A variety of computational methods, mainly based on machine learning approaches, have been developed in the last decades to tackle this challenging problem.
arxiv   +1 more source

Stability-mediated epistasis constrains the evolution of an influenza protein. [PDF]

, 2013
John Maynard Smith compared protein evolution to the game where one word is converted into another a single letter at a time, with the constraint that all intermediates are words: WORD→WORE→GORE→GONE→GENE. In this analogy, epistasis constrains evolution,
Bloom, Jesse D, Gong, Lizhi Ian, Suchard, Marc A   +2 more
core   +1 more source