Results 71 to 80 of about 343,320 (257)
Human monoclonal islet specific autoantibodies share features of islet cell and 64 kDa antibodies [PDF]
, 1993 The first human monoclonal islet cell antibodies of the IgG class (MICA 1-6) obtained from an individual with Type 1 (insulin-dependent) diabetes mellitus were cytoplasmic islet cell antibodies selected by the indirect immunofluorescence test on pancreas
DJ Garry +19 more
core +1 more source
Viruses, 2019 Dengue is currently one of the most important arbovirus infections worldwide. Early diagnosis is important for disease outcome, particularly for those afflicted with the severe forms of infection.
Alice F. Versiani +6 more
doaj +1 more source
Universal characterization of epitope immunodominance from a multi-scale model of clonal competition in germinal centers [PDF]
arXiv, 2023 We introduce a novel, multi-scale model for affinity maturation, which aims to capture the intra-clonal, inter-clonal and epitope-specific organization of the B cell population in a germinal center. We describe the evolution of the B cell population via a quasispecies dynamics, with species corresponding to unique B cell receptors (BCRs), where the ...
arxiv
Dynamics of Virus and Immune Response in Multi-Epitope Network [PDF]
, 2017 The host immune response can often efficiently suppress a virus infection, which may lead to selection for immune-resistant viral variants within the host. For example, during HIV infection, an array of CTL immune response populations recognize specific epitopes (viral proteins) presented on the surface of infected cells to effectively mediate their ...
arxiv +1 more source
Autoantibody recognition mechanisms of MUC1 [PDF]
, 2016 The most cost-effective blood-based, noninvasive molecular cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities ...
arxiv +1 more source
MATE-Pred: Multimodal Attention-based TCR-Epitope interaction Predictor [PDF]
arXiv, 2023 An accurate binding affinity prediction between T-cell receptors and epitopes contributes decisively to develop successful immunotherapy strategies. Some state-of-the-art computational methods implement deep learning techniques by integrating evolutionary features to convert the amino acid residues of cell receptors and epitope sequences into numerical
arxiv
An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction [PDF]
Journal of Immunology Research, 2016 Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-depth in silico analysis and categorization of the experimentally identified epitopes stimulated ...
Lenka Potocnakova +2 more
openaire +3 more sources
Quasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis
Virulence, 2021 New SARS-CoV-2 mutants have been continuously indentified with enhanced transmission ever since its outbreak in early 2020. As an RNA virus, SARS-CoV-2 has a high mutation rate due to the low fidelity of RNA polymerase.
Rongsui Gao +16 more
doaj +1 more source
A Humanized Mouse Strain That Develops Spontaneously Immune-Mediated Diabetes
Frontiers in Immunology, 2021 To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse.
Sandrine Luce +20 more
doaj +1 more source
HBsAg-vectored DNA vaccines elicit concomitant protective responses to multiple CTL epitopes relevant in human disease. [PDF]
, 2008 Vaccines capable of controlling neoplastic and infectious diseases which depend on the cellular immune response for their resolution, have proven difficult to develop.
Allan Gould +7 more
core +1 more source