Results 71 to 80 of about 505,722 (385)

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

Population Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Exploring glutathione transferase and Cathepsin L-like proteinase for designing of epitopes-based vaccine against Fasciola hepatica by immunoinformatics and biophysics studies

Frontiers in Immunology
Fasciolosis is a zoonotic infection and is considered a developing deserted tropical illness threatening ruminant productivity and causing financial losses.
Hassan H. Alhassan, Muhammad Ikram Ullah, Abdurahman A. Niazy, Sami I. Alzarea, Omar Awad Alsaidan, Abdulaziz Ibrahim Alzarea, Aseel Awad Alsaidan, Abulaziz A. Alhassan, Muharib Alruwaili, Yasir S. Alruwaili, Yasir S. Alruwaili   +10 more
doaj   +1 more source

Computational Prediction of B-cell Epitopes of Mycobacterium tuberculosis-Implications in Vaccine Design

Mediterranean Journal of Infection, Microbes and Antimicrobials, 2021
Introduction: Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis. Bacillus Calmette-Guérin is the only vaccine available for TB.
Esakkimuthu THANGAMARIAPPAN, Manikandan MOHAN, Krishnan SUNDAR   +2 more
doaj   +1 more source

Inferring HIV escape rates from multi-locus genotype data [PDF]

, 2013
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate an anti-viral response that can kill the infected cells.
Kessinger, Taylor A., Neher, Richard A., Perelson, Alan S.   +2 more
core   +3 more sources

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

Nature Communications, 2018
The CRISPR-Cas9 system has raised hopes for developing personalized gene therapies for complex diseases. Its application for genetic and epigenetic therapies in humans raises concerns over immunogenicity of the bacterially derived Cas9 protein.
S. Ferdosi, Radwa Ewaisha, Farzaneh Moghadam, S. Krishna, Jin G. Park, M. Ebrahimkhani, S. Kiani, K. Anderson   +7 more
semanticscholar   +1 more source

Network topology drives population temporal variability in experimental habitat networks

Population Ecology, EarlyView.
Habitat patches connected by dispersal pathways form habitat networks. We explored how network topology affects population outcomes in laboratory experiments using a model species (Daphnia carinata). Central habitat nodes in complex lattice networks exhibited lower temporal variability in population sizes, suggesting they support more stable ...
Yiwen Xu, J. Angus Webb, William D. Bovill, Elise L. King   +3 more
wiley   +1 more source

A Novel Algorithm for Macromolecular Epitope Matching

Algorithms, 2009
Many macromolecules, namely proteins, show functional substructures or epitopes defined by characteristic spatial arrangements of groups of specific atoms or residues.
Stanislav Jakuschev, Daniel Hoffmann
doaj   +1 more source

Orf Virus-Based Vaccine Vector D1701-V Induces Strong CD8+ T Cell Response against the Transgene but Not against ORFV-Derived Epitopes

Vaccines, 2020
The potency of viral vector-based vaccines depends on their ability to induce strong transgene-specific immune response without triggering anti-vector immunity.
Alena Reguzova, Michael Ghosh, Melanie Müller, Hanns-Joachim Rziha, Ralf Amann   +4 more
doaj   +1 more source

Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates

ACS Infectious Diseases, 2016
Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health and socioeconomic stability.
Qidi Wang, Lianfeng Zhang, K. Kuwahara, Li Li, Zijie Liu, Taisheng Li, Hua Zhu, Jiangning Liu, Yanfeng Xu, Jing Xie, H. Morioka, N. Sakaguchi, Chuan Qin, Gang Liu   +13 more
semanticscholar   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source