Results 201 to 210 of about 5,392 (239)

M6A RNA epitranscriptome dynamics linked to major depressive disorder and suicide risk

Neuropsychopharmacology
Major depressive disorder (MDD) is the most prevalent psychiatric disorder. MDD patients are at substantially increased risk of dying by suicide. The molecular mechanisms associated with MDD and associated suicide are not clearly understood, which ...
B. Roy, Y. Dwivedi
semanticscholar   +1 more source

2151-LB: The Hypothalamic Epitranscriptome of Prader-Willi Syndrome (PWS) during Early Development Shows Alterations to Insulin Signaling and Homeostatic Response

Diabetes
Introduction and Objective: We are investigating the CNS basis of hyperphagia and disrupted energy homeostasis in PWS using human cellular models of brain development. The homeostatic response to nutrient status and signaling appears dysregulated in PWS,
L. Yao, Erika C. Espinosa, Alvaro Diaz-Badillo, R. Duggirala, D. Lehman   +4 more
semanticscholar   +1 more source

Detection techniques for epitranscriptomic marks

American Journal of Physiology-Cell Physiology, 2022
Similar to epigenetic DNA modification, RNA can be methylated and altered for stability and processing. RNA modifications, namely, epitranscriptomes, involve the following three functions: writing, erasing, and reading of marks. Methods for measurement and position detection are useful for the assessment of cellular function and human disease ...
Ken Ofusa, Ryota Chijimatsu, Hideshi Ishii   +2 more
openaire   +2 more sources

[Theranostic impact of the epitranscriptome in oncology].

Bulletin du Cancer
The rising incidence of cancer and the frequent resistance to treatments are driving the scientific community to explore new biological frontiers in search of concrete solutions for personalized patient care.
Kelly Brunel, A. Bastide, Alexandre David, S. Quesada   +3 more
semanticscholar   +1 more source

Comprehensive profiling of the epitranscriptome and translatome in rice seedlings under salt stress.

Plant Physiology
Plants dynamically regulate gene expression at multiple levels, including transcription, splicing, polyadenylation, modification, and translation, to adapt to environmental changes.
Qian Qian, Yiming Zhou, Yuli Gan, Yongqing Ling, Jiantao Tan, Mengyuan Sheng, Xin Peng, Degui Zhou, Zhonghui Zhang, Qi Liu   +9 more
semanticscholar   +1 more source

Epitranscriptomic Mass Spectrometry

Every chemical group that is added to any one of the canonical ribonucleotides in a transcript would create a specific RNA modification. Currently, 170+ RNA modifications have been identified. A specific epitranscriptome refers to all the RNA modifications in a given biological system and is considered to play an important role in the regulations of ...
Hongzhou, Wang, Frank Morales, Shnaider, Elizabeth, Martin, Norman H L, Chiu   +3 more
openaire   +2 more sources

Epitranscriptomics and Diseases

2021
The role of epitranscriptomics, i.e., RNA base modification, as a component of a “methylome” in disease has emerged as a result of the development of next generation sequencing and other related state-of-art technologies. Epitranscriptomic state is controlled by writing, erasing, and reading methylation, which is mediated by enzymatic reactions.
Masamitsu Konno, Hideshi Ishii
openaire   +1 more source

Pan-modification profiling facilitates a cross-evolutionary dissection of the thermoregulated ribosomal epitranscriptome.

Cell
Ribosomal RNA (rRNA) constitutes the core of ribosomes and is extensively chemically modified. Technical challenges have precluded systematically dissecting rRNA modifications and their dynamics.
Miguel Angel Garcia-Campos, Joe Georgeson, Ronit Nir, Robert Reichelt, K. Fluke, D. Matzov, Vinithra Iyer, Brett W. Burkhart, Lauren Lui, Anatoly Kustanovich, Felix Grünberger, Supuni Thalalla‐Gamage, Shereen A Howpay-Manage, Milan Gerovac, Nicolas Alexandre, Yuko Nobe, Jakub S. Nowak, Manoj Perera, A. Apostle, S. Fang, Sebastian Glatt, G. Jona, Sébastien Ferreira-Cerca, Jörg Vogel, Masato Taoka, Jordan L. Meier, Eric Westhof, T. Santangelo, Dina Grohmann, M. Shalev-Benami, Schraga Schwartz   +30 more
semanticscholar   +1 more source

The cellular epitranscriptome

2022
Several chemical modifications in cellular RNAs have been identified to date. The most common internal modification of eukaryotic RNAs is known as m6A. This modification is able to configure the outcome of gene expression by adjusting RNA decay, translation efficiency, RNA structure and alternative splicing.
openaire   +1 more source

Metabolic Regulation of the Epitranscriptome

ACS Chemical Biology, 2019
An emergent theme in cancer biology is that dysregulated energy metabolism may directly influence oncogenic gene expression. This is due to the fact that many enzymes involved in gene regulation use cofactors derived from primary metabolism, including acetyl-CoA,  S-adenosylmethionine, and 2-ketoglutarate.
Justin M. Thomas, Pedro J. Batista, Jordan L. Meier   +2 more
openaire   +2 more sources