Results 181 to 190 of about 4,508 (221)

RNA Modifications and Their Role in Regulating KSHV Replication and Pathogenic Mechanisms. [PDF]

J Med Virol
Schultz S, Gomard-Henshaw K, Muller M.
europepmc   +1 more source

The m⁶A-binding protein YTHDF3 modulates the cardiac response to stress. [PDF]

RNA
Rabolli CP, Das AS, Golubeva VA, van Berlo JH, Accornero F.   +4 more
europepmc   +1 more source

The epitranscriptome toolbox [PDF]

Cell, 2022
In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Sharon Moshitch-Moshkovitz, Dan Dominissini   +1 more
exaly   +3 more sources

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Detecting the epitranscriptome

WIREs RNA, 2021
AbstractRNA modifications and their corresponding epitranscriptomic writer and eraser enzymes regulate gene expression. Altered RNA modification levels, dysregulated writers, and sequence changes that disrupt epitranscriptomic marks have been linked to mitochondrial and neurological diseases, cancer, and multifactorial disorders.
Anwesha Sarkar, William Gasperi, Ulrike Begley, Steven Nevins, Sabrina M. Huber, Peter C. Dedon, Thomas J. Begley   +6 more
openaire   +2 more sources

Epitranscriptomics in metabolic disease

Nature Metabolism, 2023
While epigenetic modifications of DNA and histones play main roles in gene transcription regulation, recently discovered post-transcriptional RNA modifications, known as epitranscriptomic modifications, have been found to have a profound impact on gene expression by regulating RNA stability, localization and decoding efficiency.
Yoshihiro Matsumura, Fan-Yan Wei, Juro Sakai   +2 more
openaire   +2 more sources

The epitranscriptome beyond m6A

Nature Reviews Genetics, 2020
Following its transcription, RNA can be modified by >170 chemically distinct types of modifications - the epitranscriptome. In recent years, there have been substantial efforts to uncover and characterize the modifications present on mRNA, motivated by the potential of such modifications to regulate mRNA fate and by discoveries and advances in our ...
David Wiener, Schraga Schwartz
openaire   +2 more sources

Epitranscriptomic technologies and analyses

Science China Life Sciences, 2020
RNA can interact with RNA-binding proteins (RBPs), mRNA, or other non-coding RNAs (ncRNAs) to form complex regulatory networks. High-throughput CLIP-seq, degradome-seq, and RNA-RNA interactome sequencing methods represent powerful approaches to identify biologically relevant ncRNA-target and protein-ncRNA interactions.
Xiaoyu, Li, Qiao-Xia, Liang, Jin-Ran, Lin, Jinying, Peng, Jian-Hua, Yang, Chengqi, Yi, Yang, Yu, Qiangfeng Cliff, Zhang, Ke-Ren, Zhou   +8 more
openaire   +2 more sources

Epitranscriptomics in fibroblasts and fibrosis

American Journal of Physiology-Cell Physiology, 2022
Fibroblasts play an important role in the pathogenic mechanisms of several socially significant diseases, including pulmonary and cardiovascular fibrosis, liver cirrhosis, systemic sclerosis, progressive kidney disease. The alterations of the epitranscriptome, including more than 170 distinct posttranscriptional RNA modifications or editing events ...
Mirolyuba Ilieva, Shizuka Uchida
openaire   +3 more sources

N6-methyladenosine–encoded epitranscriptomics

Nature Structural & Molecular Biology, 2016
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian
Nian, Liu, Tao, Pan
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Bioinformatic tools for epitranscriptomics

American Journal of Physiology-Cell Physiology, 2023
The epitranscriptome, defined as RNA modifications that do not involve alterations in the nucleotide sequence, is a popular topic in the genomic sciences. Because we need massive computational techniques to identify epitranscriptomes within individual transcripts, many tools have been developed to infer epitranscriptomic sites as well as to process ...
openaire   +2 more sources