RNA dysfunction in age-related macular degeneration: the role of U1 snRNP complex and neurodegenerative diseases. [PDF]
Int J Retina VitreousBottos JM +5 more
europepmc +1 more source
N<sup>6</sup>-Methyladenosine (m<sup>6</sup>A)-Mediated Regulation of Lipid Metabolism: Molecular Mechanisms, Pathological Implications, and Therapeutic Perspectives. [PDF]
BiomoleculesZhu Q +5 more
europepmc +1 more source
Epigenome and Epitranscriptome: Potential Resources for Crop Improvement
International Journal of Molecular Sciences, 2021 Crop breeding faces the challenge of increasing food demand, especially under climatic changes. Conventional breeding has relied on genetic diversity by combining alleles to obtain desired traits.
Quancan Hou +2 more
exaly +2 more sources
The epitranscriptome toolbox [PDF]
Cell, 2022 In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Sharon Moshitch-Moshkovitz +2 more
exaly +3 more sources
The emerging role of epitranscriptome in shaping stress responses in plants
Plant Cell Reports, 2023 RNA modifications and editing changes constitute 'epitranscriptome' and are crucial in regulating the development and stress response in plants. Exploration of the epitranscriptome and associated machinery would facilitate the engineering of stress ...
Manu Agarwal +2 more
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Reprogramming of m 6 A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia [PDF]
RNA Biology, 2021 Hypoxia causes a series of responses supporting cells to survive in harsh environments. Substantial post-transcriptional and translational regulation during hypoxia has been observed. However, detailed regulatory mechanism in response to hypoxia is still
Yan-Jie Wang +2 more
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Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications
International Journal of Molecular Sciences, 2022 The alphabet of building blocks for RNA molecules is much larger than the standard four nucleotides. The diversity is achieved by the post-transcriptional biochemical modification of these nucleotides into distinct chemical entities that are structurally
Viktoriia A Arzumanian +2 more
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Change of Heart: the Epitranscriptome of Small Non-coding RNAs in Heart Failure
Current Heart Failure Reports, 2022 PURPOSE OF REVIEW: Small non-coding RNAs regulate gene expression and are highly implicated in heart failure. Recently, an additional level of post-transcriptional regulation has been identified, referred to as the epitranscriptome, which encompasses the
Tamar Woudenberg +2 more
exaly +3 more sources
The Chloroplast Epitranscriptome: Factors, Sites, Regulation, and Detection Methods
Genes, 2021 Modifications in nucleic acids are present in all three domains of life. More than 170 distinct chemical modifications have been reported in cellular RNAs to date.
Nikolay Manavski +2 more
exaly +2 more sources
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Detecting the epitranscriptome
WIREs RNA, 2021AbstractRNA modifications and their corresponding epitranscriptomic writer and eraser enzymes regulate gene expression. Altered RNA modification levels, dysregulated writers, and sequence changes that disrupt epitranscriptomic marks have been linked to mitochondrial and neurological diseases, cancer, and multifactorial disorders.
Anwesha Sarkar +6 more
openaire +2 more sources