Results 21 to 30 of about 14,810 (242)

Rationale and design of MinerAlocorticoid Receptor antagonist Tolerability Study‐Heart Failure (ARTS‐HF): a randomized study of finerenone vs. eplerenone in patients who have worsening chronic heart failure with diabetes and/or chronic kidney disease [PDF]

, 2015
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110733/1/ejhf218 ...
Albert, Allen, Bayes-Genis, Berry, Bettencourt, Butler, Bärfacker, Dunlay, Edwards, Eschalier, Ezekowitz, Frantz, Fruhwald, Gheorghiade, Gheorghiade, Gheorghiade, Hamm, Hartmann, Iraqi, Juurlink, Kolkhof, Kolkhof, Maggioni, Maggioni, Maggioni, Masson, McMurray, Orena, Pascual-Figal, Pitt, Pitt, Skali, Tsutamoto, Udelson, Verdiani, Wright, Yamaji, Yamaji, Yancy, Zannad   +39 more
core   +4 more sources

Eplerenone improves kidney function and cardiac performance in obese male mice. [PDF]

Diabet Med
Abstract Aims Renin‐angiotensin‐aldosterone system (RAAS) activation mediates obesity‐associated cardiorenal dysfunction. Due to an incomplete understanding of the molecular mechanisms, the clinical use of RAAS antagonism in obesity‐associated cardiometabolic complications remains uncertain.
Banah AK, Qi B, Koh R, Lawlor A, Wang T, Musale V, Mains J, Murdoch CE, Kang L.   +8 more
europepmc   +2 more sources

Eplerenone [PDF]

Nature Reviews Drug Discovery, 2003
Data from animal studies and clinical trials indicate that aldosterone causes cardiovascular and renal injury through mineralocorticoid receptor–dependent mechanisms. However, although aldosterone receptor antagonism reduces mortality in patients with congestive heart failure, the progestational and antiandrogenic side effects of the nonspecific ...
Ruth, Brown, Jeremy, Quirk, Peter, Kirkpatrick   +2 more
openaire   +4 more sources

EVATRAN (The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients): study protocol for a cross-over randomized controlled trial. [PDF]

Trials
Simon A, Girerd N, Jaisser F, Bozec E, Lepage X, Mercklé L, Rossignol P, Frimat L, Girerd S.   +8 more
europepmc   +3 more sources

Eplerenone, diabetes, and chronic kidney disease in patients hospitalized for acute heart failure: findings from the EARLIER trial. [PDF]

Cardiovasc Diabetol
Kobayashi M, Yamashina A, Satomi K, Watanabe M, Takagi R, Tezuka A, Ito S, Asakura M, Kitakaze M.   +8 more
europepmc   +3 more sources

A Prospective Study of Eplerenone in the Treatment of Patients with Glomerulonephritis

Biomedicines, 2023
Background: High aldosterone levels contribute to kidney disease progression, while spironolactone in combination with ACEi or ARBs can potentially reduce proteinuria and ameliorate kidney function deterioration.
Marios Papasotiriou, Georgia Andrianna Georgopoulou, Adamantia Mpratsiakou, Theodoros Ntrinias, Georgios Lyras, Dimitrios S. Goumenos, Evangelos Papachristou   +6 more
doaj   +1 more source

Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study [PDF]

, 2018
Objective: Aldosterone stimulates cardiac collagen synthesis. Circulating biomarkers of collagen turnover provide a useful tool for the assessment of cardiac remodeling in patients with an acute myocardial infarction (MI).
A Struthers, AH Ellims, AS Levey, B Lopez, B Lopez, Bertram Pitt, Christian W. Hamm, CS Cook, D Buckert, D Quilliot, Esteban Lopez de Sa, Eva Turgonyi, F Azibani, F Beygui, F Zannad, F Zannad, Faiez Zannad, Freek Verheugt, G Condorelli, G Klappacher, G Montalescot, Gilles Montalescot, H Izawa, Harry Shi, John Vincent, João Pedro Ferreira, JP Ferreira, Kévin Duarte, M Gyongyosi, M Hayashi, Marcus Flather, Miguel Orri, O Huttin, P Uusimaa, Patrick Rossignol, PS Jhund, V Krizhanovsky, W Iraqi, Y Sun, YH Lin   +39 more
core   +16 more sources

Influence of combined eplerenone, aflibercept and nepafenac therapy on central serous chorioretinopathy. [PDF]

Int J Ophthalmol
Ewais WA, Samy Ali L, Aboalazayem F.
europepmc   +2 more sources

Bilateral bullous central serous chorioretinopathy treated with PDT and eplerenone

American Journal of Ophthalmology Case Reports, 2022
Purpose: To report a case evaluating PDT and eplerenone therapy in a patient with bilateral bullous central serous chorioretinopathy. Observations: A 30-year-old male was referred for worsening bilateral bullous central serous chorioretinopathy (bCSCR ...
William J. Anderson, Bradley T. Smith
doaj   +1 more source

Effect of Eplerenone, a Selective Aldosterone Blocker, on the Development of Diabetic Nephropathy in Type 2 Diabetic Rats [PDF]

Diabetes & Metabolism Journal, 2012
BackgroundAldosterone antagonists are reported to have beneficial effects on diabetic nephropathy by effective blocking of the renin-angiotensin-aldosterone system.
Jae Hee Ahn, Ho Cheol Hong, Myong Jin Cho, Yoon Jung Kim, Hae Yoon Choi, Chai Ryoung Eun, Sae Jeong Yang, Hye Jin Yoo, Hee Young Kim, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim   +14 more
doaj   +1 more source