Results 71 to 80 of about 14,810 (242)

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 228-240, January 2026.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Effect of eplerenone on aldosterone and von Willebrand factor levelsin patients with myocardial infarction and chronic kidney disease

Zaporožskij Medicinskij Žurnal, 2022
Aim: to study the levels of aldosterone and von Willebrand factor (VWF) in patients with Q-wave acute myocardial infarction (Q-AMI) and underling chronic kidney disease (CKD) using aldosterone antagonists. Materials and methods.
V. K. Tashchuk, O. S. Polianska, O. I. Hulaha   +2 more
doaj   +1 more source

Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes [PDF]

, 2013
Cardiac steatosis and apoptosis are key processes in diabetic cardiomyopathy, but the underlying mechanisms have not been elucidated, leading to a lack of effective therapy.
Ares-Carrasco, Sara, Barbas, Coral, Caro-Vadillo, Alicia, Egido de los Ríos, Jesús, Ferrarini, Alessia, Klett-Mingo, Mercedes, Lorenzo, Óscar, Picatoste, Belén, Ramírez, Elisa, Rupérez, Francisco Javier, Tuñón, José Luis Morales   +10 more
core   +3 more sources

Alcohol and the endocrine system: A critical review of disruptions, potential mechanisms, and health implications

Alcohol, Clinical and Experimental Research, Volume 50, Issue 1, January 2026.
The endocrine system coordinates whole body cellular function and maintains homeostasis. Alcohol impacts the integrity of endocrine regulation at multiple sites, contributing to risk for comorbidities. Some of the alcohol‐mediated pathophysiological effects on the endocrine system include alterations in receptor expression and responsiveness, protein ...
Patricia E. Molina, Liz Simon
wiley   +1 more source

Analysis of eplerenone in the FDA adverse event reporting system (FAERS) database: a focus on overall patient population and gender-specific subgroups

Frontiers in Pharmacology
Introduction: Eplerenone is approved for the treatment of hypertension as well as symptomatic heart failure with reduced ejection fraction (HFrEF) following an acute myocardial infarction.
Xin Guan, Yusi Yang, Xinru Li, Yue Feng, Jizhen Li, Xuewen Li   +5 more
doaj   +1 more source

Aldosterone as a renal growth factor [PDF]

, 2010
Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis.
Dooley, Ruth, Harvey, Brian J, Thomas, Warren   +2 more
core   +1 more source

Treatment of Heart Failure with Preserved Ejection Fraction [PDF]

, 2011
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90240/1/phco.31.3.312 ...
Barnes, Megan M., Bleske, Barry E., Dorsch, Michael P., Hummel, Scott L., Koelling, Todd M.   +4 more
core   +1 more source

Lipid-based nano-formulation platform for eplerenone oral delivery as a potential treatment of chronic central serous chorioretinopathy: in-vitro optimization and ex-vivo assessment [PDF]

, 2021
Eman Abdelhakeem, Mohamed A. El-Nabarawi, Rehab Nabil Shamma   +2 more
openalex   +1 more source

The Use of Tranexamic Acid to Treat Melasma: A Systematic Review and Meta‐Analysis

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Introduction Tranexamic acid (TXA) is a synthetic derivative of the amino acid lysine that inhibits bleeding due to its effects on plasminogen conversion, approved by the FDA to treat menorrhagia and prevent bleeding in hemophilia patients undergoing dental extraction.
Nabila Scabine Pessotti, Vinicius Tassoni Civile, Talita Andrade Brandao, Felipe Ribeiro, Gisele Viana de Oliveira, Nathalia Sernizon Guimarães, Denise Steiner, Mahlatse Kgokolo   +7 more
wiley   +1 more source

Modulation of the acute defence reaction by eplerenone prevents cardiac disease progression in viral myocarditis

ESC Heart Failure, 2020
Aims Left ventricular (LV) dysfunction in viral myocarditis is attributed to myocardial inflammation and fibrosis, inducing acute and long‐time cardiac damage. Interventions are not established.
Carsten Tschöpe, Sophie Van Linthout, Sebastian Jäger, Robert Arndt, Tobias Trippel, Irene Müller, Ahmed Elsanhoury, Susanne Rutschow, Stefan D. Anker, Heinz‐Peter Schultheiss, Matthias Pauschinger, Frank Spillmann, Kathleen Pappritz   +12 more
doaj   +1 more source