Results 91 to 100 of about 10,873 (203)

Combination of ADAM17 knockdown with eplerenone is more effective than single therapy in ameliorating diabetic cardiomyopathy

Frontiers in Pharmacology
BackgroundThe renin-angiotensin-aldosterone system (RAAS) members, especially Ang II and aldosterone, play key roles in the pathogenesis of diabetic cardiomyopathy (DCM).
Lin Xie, Dejin Zang, Jianmin Yang, Fei Xue, Wenhai Sui, Yun Zhang, Yun Zhang   +6 more
doaj   +1 more source

Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats

, 2004
We examined the effect of different levels of salt intake on the role of aldosterone on cardiac and vascular changes in salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP). Eleven-week-old SHRSP were fed high-salt (4.2% NaCl), normal-salt (0.
Touyz, R.M., IGLARZ M, SAVOIA, Carmine, Iglarz, M., Schiffrin, E.L., Savoia, C., TOUYZ RM, SCHIFFRIN EL, ENDEMANN DH, Endemann, D.H.   +9 more
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AZD9977 and eplerenone activities on MR, GR, PR and AR in binding assays.

, 2018
AZD9977 and eplerenone activities on MR, GR, PR and AR in binding assays.
Anna Björnson Granqvist (4885225), Stefan Geschwindner (840623), Karl Edman (2572066), Anna Aagaard (3632740), Rasmus Jansson-Löfmark (4885222), Ulrika Johansson (217525), Frédéric Jaisser (4885231), Kenneth L. Granberg (4885228), Judith Hartleib-Geschwindner (4885219), Susanna Myhre (4662763), Yufeng Huang (782683), Lena William-Olsson (4885234), Krister Bamberg (583828), Anders Gunnarsson (1454497)   +13 more
core   +1 more source

Effects of eplerenone on resistance to antihypertensive medication in patients with primary or secondary hyperaldosteronism

, 2017
Background and ObjectivesResistant hypertension is an important problem; nearly half of diagnosed hypertensives are not controlled to target blood pressure levels, and approximately 90% of strokes occur among patients with resistant hypertension. Primary
Daniel G. Hackam, J. David Spence, Chrysi Bogiatzi, George K. Dresser, Mariya Kuk   +4 more
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Postpartum administration of eplerenone to mitigate vascular dysfunction in mice following a preeclampsia-like pregnancy

Scientific Reports
Preeclampsia is a severe pregnancy complication associated with substantial injury to systemic vasculature, major organs, and the feto-placental unit, with an approximate mortality rate of 76,000 pregnant women and 500,000 babies each year.
Natalie K. Binder, Natasha de Alwis, Sally Beard, Bianca R. Fato, Anjali Garg, Lydia Baird, Morag J. Young, Natalie J. Hannan   +7 more
doaj   +1 more source

AZD9977 and eplerenone activities in reporter gene assays.

, 2018
Concentration response curves of AZD9977 and eplerenone tested in a reporter gene assay in (a) presence or (b) absence of 0.1 nM aldosterone. n = 4, average ± SD.
Anna Björnson Granqvist (4885225), Stefan Geschwindner (840623), Karl Edman (2572066), Anna Aagaard (3632740), Rasmus Jansson-Löfmark (4885222), Ulrika Johansson (217525), Frédéric Jaisser (4885231), Kenneth L. Granberg (4885228), Judith Hartleib-Geschwindner (4885219), Susanna Myhre (4662763), Yufeng Huang (782683), Lena William-Olsson (4885234), Krister Bamberg (583828), Anders Gunnarsson (1454497)   +13 more
core   +1 more source

AZD9977 and eplerenone activities in reporter gene assays for human, mouse and rat MR.

, 2018
AZD9977 and eplerenone activities in reporter gene assays for human, mouse and rat MR.
Anna Björnson Granqvist (4885225), Stefan Geschwindner (840623), Karl Edman (2572066), Anna Aagaard (3632740), Rasmus Jansson-Löfmark (4885222), Ulrika Johansson (217525), Frédéric Jaisser (4885231), Kenneth L. Granberg (4885228), Judith Hartleib-Geschwindner (4885219), Susanna Myhre (4662763), Yufeng Huang (782683), Lena William-Olsson (4885234), Krister Bamberg (583828), Anders Gunnarsson (1454497)   +13 more
core   +1 more source

Eplerenone in chronic heart failure with depressed systolic function

, 2015
Eplerenone is a selective mineralocorticoid receptor antagonist that has been recently included in the treatment of patients with chronic heart failure (CHF) and reduced systolic function.
Volterrani M., Iellamo F.
core   +1 more source

Adverse events associated with early initiation of Eplerenone in patients hospitalized for acute heart failure

International audience Eplerenone did not elevate rates of WRF, hyperkalemia, hypotension and dehydration. Baseline HF severity and comorbidity burden were associated with adverse events.
Kitakaze, Masafumi, Asakura, Masanori, Satomi, Kazuhiro, Ferreira, João Pedro, Ito, Shin, Kobayashi, Masatake, Yamashina, Akira, Tezuka, Ayako   +7 more
core   +1 more source

The long-term antiproteinuric effect of eplerenone, a selective aldosterone blocker, in patients with non-diabetic chronic kidney disease

, 2011
Introduction: There is still insufficient data concerning the clinical effects of eplerenone, a selective aldosterone blocker, in patients with non-diabetic chronic kidney disease (CKD).
Nobuo Tsuboi, Tetsuya Kawamura, Hideo Okonogi, Tatsuo Hosoya, Takeo Ishii   +4 more
core   +1 more source