Results 71 to 80 of about 10,873 (203)

Feasibility of Decentralised Response‐Guided Albuminuria Monitoring to Optimise Empagliflozin and Finerenone Therapy in Type 2 Diabetes and Chronic Kidney Disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9412-9422, October 2026.
ABSTRACT Aims To assess the feasibility of a decentralised response‐guided trial and to characterise urinary albumin‐to‐creatinine ratio (UACR) responses to empagliflozin and finerenone in type 2 diabetes and chronic kidney disease (CKD). Materials and Methods Adults with type 2 diabetes, estimated glomerular filtration rate (eGFR) ≥ 25 mL/min/1.73 m2,
Jelle M. Beernink, Gozewijn D. Laverman, Hiddo J. L. Heerspink   +2 more
wiley   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

Mineralocorticoid receptor antagonists, a class beyond spironolactone. focus on the special pharmacologic properties of eplerenone

, 2015
The renin-angiotensin-aldosterone system can be blocked at specific levels by using different classes of pharmacologic agents, including angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers and mineralocorticoid receptor antagonists.
Ristic, Arsen, Simeunovic, Dejan, Seferovic, Petar M, Lalic, Nebojsa, Rosano, Giuseppe, PELLICCIA, FRANCESCO, Zivkovic, Ivana, Seferovic, Jelena, Milinkovic, Ivan   +8 more
core   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Willingness to pay for a reduction in the mortality risk after a myocardial infarction: an aplication of the contingent valuation method to the case of eplerenone [PDF]

Background: In order to allocate health care resources more efficiently it is necessary to relate health improvements provided by new medicines with their cost.
Veronica Farreras, Jose Luis Pinto-Prades, Jaime Fernández de Bobadilla   +2 more
core  

Risk factors for the development of subretinal fluid in the fellow eyes of patients with chronic central serous chorioretinopathy

Acta Ophthalmologica, Volume 104, Issue 6, Page 666-673, September 2026.
Abstract Purpose To assess the risk of subretinal fluid (SRF) development in the fellow eye of chronic central serous chorioretinopathy (cCSC) patients with unilateral SRF at baseline. Methods Medical records of 334 presumed cCSC patients were retrospectively reviewed.
Helena M. A. Feenstra, Tahir Cakar, Joost Brinks, Camiel J. F. Boon, Elon H. C. van Dijk   +4 more
wiley   +1 more source

Reducing Cardiovascular Risk in Patients following MI with Eplerenone

, 2010
Background In the event of an MI, the presence of LV systolic dysfunction with or without heart failure is associated with a poorer prognosis. Elevation of aldosterone levels also results in a poor prognosis after an MI.
Sushma Rekhraj, Allan Struthers, Benjamin Szwejkowski   +2 more
core   +1 more source

Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients [PDF]

, 2008
Some antihypertensive agents may improve resistance artery remodeling in hypertensive patients whereas other agents may not, for similar blood pressure reduction.
Touyz, R.M., Amiri, F., SAVOIA, Carmine, Schiffrin, E.L., Savoia, C., TOUYZ RM, SCHIFFRIN EL, AMIRI F   +7 more
core   +1 more source

Eplerenone in pregnancy

Obstetric Medicine
Eplerenone is a mineralocorticoid receptor antagonist with minimal affinity for androgen receptors. Mineralocorticoid receptor antagonists are efficacious in the management of resistant hypertension, obstructive sleep apnea, cardiac dysfunction, renal tubular disorders, hepatic cirrhosis, portal hypertension, diabetic nephropathy, proteinuric kidney ...
openaire   +3 more sources

Urine electrolytes guide treatment of Gitelman syndrome and recurrent syncope—A case report

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Syncope is a common reason for inpatient admission. Few case studies describe an association between syncope and Gitelman syndrome (GS). Herein, we present a case of a woman with hypokalemia and recurrent syncope which eventually led to a diagnosis of GS. A physiologic approach to urine electrolyte interpretation informed clinical decisions to
Saloni Agrawal, Kenneth M. Fifer, Samira S. Farouk, Joshua L. Rein   +3 more
wiley   +1 more source