Results 31 to 40 of about 44,698 (310)
Autocrine stimulation by erythropoietin (Epo) requires Epo secretion [PDF]
Blood, 1994 Abstract Erythropoietin (Epo) autocrine stimulation has been implicated in erythroblastic leukemia. To examine whether this stimulation could occur intracellularly, we developed Epo autocrine models of stimulation in the human pluripotent UT-7 cell line. Retroviral expression of Epo totally abolished the growth factor requirement of UT-7
J L, Villeval +5 more
openaire +3 more sources
Rhinology journal, 2021 EPOS2020 is the 4th and most recent version of the European Position Paper on Rhinosinusitis and Nasal Polyps which was first published in 2005. It aims to provide the most up to date scientifically robust information on the topic published in the literature which has been critically analysed by an international group of clinicians drawn from all ...
Hopkins, C. +19 more
openaire +7 more sources
EPO-B and EPO-D induces apoptosis through p53 activation in VSMCs.
, 2016 (A) VSMCs were cultured in an eight chambered glass culture slide, and then serum starved for 12h. After treatment of EPO-B and EPO-D (1 to 100 nM), or 0.1% DMSO (vehicle) for 24h, cells were stimulated with PDGF-BB (50 ng/mL) for 24 h. Activation of p53
Dong Ju Son (597345) +2 more
core +1 more source
Physiological Reports, 2020 The detection of erythropoietin (Epo) protein by Western blotting has required pre‐purification of the sample. We developed a new Western blot method to detect plasma and urinary Epo using deglycosylation.
Yukiko Yasuoka +17 more
doaj +1 more source
EPO-B and EPO-D induces p-53 dependent apoptotic signaling pathway.
, 2016 (A) VSMCs were treated with EPO-B and EPO-D (1 to 100 nM), or 0.1% DMSO in serum-free media for 24h, then stimulated with PDGF-BB (50 ng/mL). After 24 h, cells were lysed and Bax, mitochondrial cytochrome c release and cleaved caspase-3 expressions were ...
Dong Ju Son (597345) +2 more
core +1 more source
Neuronal nitric oxide synthase is required for erythropoietin stimulated erythropoiesis in mice
Frontiers in Cell and Developmental Biology, 2023 Introduction: Erythropoietin (EPO), produced in the kidney in a hypoxia responsive manner, is required for red blood cell production. In non-erythroid tissue, EPO increases endothelial cell production of nitric oxide (NO) and endothelial nitric oxide ...
Jeeyoung Lee +6 more
doaj +1 more source
EPO tecting the Endothelium [PDF]
British Journal of Pharmacology, 2007 Erythropoietin is a 30.4 kDa protein that is produced and secreted from the kidney in response to anemia and hypobaric hypoxia. Binding of EPO to its receptor (EPO‐R) on bone marrow‐derived erythroid progenitor cells results in the stimulation of red blood cell production. Evidence is accumulating however, that the biological effects of recombinant EPO
T E, Peterson, Z S, Katusic
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley +1 more source
Neurobiology of Disease, 2006 Using an established mouse model of human periventricular leukomalacia, we investigated whether EPO could reduce excitotoxic damage. When administered 1 h following intracerebral injection of 10 μg ibotenic acid at day 5 of life, both a single injection ...
Matthias Keller +7 more
doaj +1 more source
EPO-B and EPO-D induces apoptotic cell death and mitotic catastrophe in VSMCs.
, 2016 (A-B) VSMCs were cultured in an eight chambered glass culture slide, and then serum starved for 12h, cells were then treated with 1 to 100 nM of (A) EPO-B and (B) EPO-D or 0.1% DMSO (vehicle) for 24h, cells were stimulated with PDGF-BB (50 ng/mL).
Dong Ju Son (597345) +2 more
core +1 more source