Results 1 to 10 of about 24,821 (222)

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Alzheimer’s disease, cardiovascular disease, and other cardiometabolic disorders may share inflammatory origins. Lipid mediators, including oxylipins, endocannabinoids, bile acids, and steroids, regulate inflammation, energy metabolism, and ...
Kamil Borkowski, Theresa L. Pedersen, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, Chadwick M. Hales, Eric B. Dammer, Colette Blach, Gregory Louie, Rima Kaddurah-Daouk, John W. Newman, Alzheimer’s Disease Metabolomics Consortium   +11 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
core   +1 more source

Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis

Metabolites, 2020
While a complex network of cellular and molecular events is known to be involved in the pathophysiological mechanism of chronic kidney disease (CKD), the divergence point between reversal and progression and the event that triggers CKD progression are ...
Kyoung Hee Han, Bora Kim, Sang Chun Ji, Hee Gyung Kang, Hae Il Cheong, Joo-Youn Cho, Il-Soo Ha   +6 more
doaj   +1 more source

Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]

, 2019
Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska, Enghard, Philipp, Gollasch, Maik, Hammock, Bruce D., Klocke, Jan, Riemekasten, Gabriela, Rudolph, Birgit, Schunck, Wolf-Hagen, Ulu, Arzu, Wu, Kaiyin   +9 more
core   +2 more sources

Data set of optimal parameters for colorimetric red assay of epoxide hydrolase activity

Data in Brief, 2016
The data presented in this article are related to the research article entitled “Epoxide hydrolase of Trichoderma reesei: Biochemical properties and conformational characterization” [1].
Gabriel Stephani de Oliveira, Patricia Pereira Adriani, Flavia Garcia Borges, Adriana Rios Lopes, Patricia T. Campana, Felipe S. Chambergo   +5 more
doaj   +1 more source

Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles

Nature Communications, 2022
Chiral heterocyclic compounds are privileged structures in medicinal chemistry. Here, the authors report an in silico strategy for the enzymatic synthesis of pharmaceutically significant chiral N- and O-heterocycles via Baldwin cyclization of hydroxy ...
Jun-Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa-Guang Zhang, Wuyuan Zhang, Jun-An Ma, Manfred T. Reetz, Zhoutong Sun   +9 more
doaj   +1 more source

Evidence for the role of EPHX2 gene variants in anorexia nervosa. [PDF]

, 2013
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants.
Bansal, V, Berenson, G, Bergen, AW, Berrettini, W, Bloss, CS, Brandt, H, Bulik, CM, Carson, A, Chen, W, Crawford, S, Crow, S, Darst, BF, Duvvuri, V, Fichter, MM, Galvez, L, Halmi, KA, Johnson, C, Kaplan, AS, Kaye, W, Keel, P, Klump, KL, La Via, M, Levy, S, Libiger, O, Lilenfeld, L, Magistretti, P, Mitchell, JE, Murray, S, Pham, P, Phillips, T, Plotnicov, K, Rotondo, A, Schork, NJ, Scott-Van Zeeland, AA, Shih, PB, Smith, EN, Srinivasan, S, Strober, M, Tewhey, R, Tisch, R, Topol, EJ, Torkamani, A, Treasure, J, Villarasa, N, Wineinger, N, Woodside, DB, Zhang, G   +46 more
core   +1 more source

Lysophosphatidic acids are new substrates for the phosphatase domain of soluble epoxide hydrolase

Journal of Lipid Research, 2012
Soluble epoxide hydrolase (sEH) is a bifunctional enzyme that has a C-terminus epoxide hydrolase domain and an N-terminus phosphatase domain. The endogenous substrates of epoxide hydrolase are known to be epoxyeicosatrienoic acids, but the endogenous ...
Ami Oguro, Susumu Imaoka
doaj   +1 more source

The impact of the soluble epoxide hydrolase cascade on periodontal tissues

Frontiers in Dental Medicine, 2023
Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing ...
Henrique Ballassini Abdalla, Thomas E. Van Dyke, Thomas E. Van Dyke   +2 more
doaj   +1 more source

A novel activity of microsomal epoxide hydrolase: metabolism of the endocannabinoid 2-arachidonoylglycerol

Journal of Lipid Research, 2014
Microsomal epoxide hydrolase (EPHX1, EC 3.3.2.9) is a highly abundant α/β-hydrolase enzyme that is known for its catalytical epoxide hydrolase activity.
Kasem Nithipatikom, Michael P. Endsley, Adam W. Pfeiffer, John R. Falck, William B. Campbell   +4 more
doaj   +1 more source