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Epoxide hydrolases: biochemistry and molecular biology [PDF]

Chemico-Biological Interactions, 2000
Epoxides are organic three-membered oxygen compounds that arise from oxidative metabolism of endogenous, as well as xenobiotic compounds via chemical and enzymatic oxidation processes, including the cytochrome P450 monooxygenase system. The resultant epoxides are typically unstable in aqueous environments and chemically reactive.
Adrian J. Fretland, Curtis J. Omiecinski
openalex   +4 more sources

Soluble Epoxide Hydrolase as a Therapeutic Target for Neuropsychiatric Disorders

International Journal of Molecular Sciences, 2022
It has been found that soluble epoxide hydrolase (sEH; encoded by the EPHX2 gene) in the metabolism of polyunsaturated fatty acids (PUFAs) plays a key role in inflammation, which, in turn, plays a part in the pathogenesis of neuropsychiatric disorders ...
J. Shan, K. Hashimoto
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Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

Journal of Medicinal Chemistry, 2021
This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of
B. Hammock, C. McReynolds, K. Wagner, A. Buckpitt, I. Cortés-Puch, G. Croston, K. S. Lee, Jun Yang, W. Schmidt, S. Hwang   +9 more
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Soluble Epoxide Hydrolase in Atherosclerosis [PDF]

Current Atherosclerosis Reports, 2010
Like many eicosanoids, epoxyeicosatrienoic acids (EETs) have multiple biological functions, including reduction of blood pressure, inflammation, and atherosclerosis in multiple species. Hydration of EETs by the soluble epoxide hydrolase (sEH) is the major route of their degradation to the less bioactive diols.
Wang, Yi-Xin Jim, Ulu, Arzu, Zhang, Le-Ning, Hammock, Bruce   +3 more
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Epoxide Hydrolases: Multipotential Biocatalysts

International Journal of Molecular Sciences, 2023
Epoxide hydrolases are attractive and industrially important biocatalysts. They can catalyze the enantioselective hydrolysis of epoxides to the corresponding diols as chiral building blocks for bioactive compounds and drugs. In this review article, we discuss the state of the art and development potential of epoxide hydrolases as biocatalysts based on ...
Marek Bučko, Katarína Kaniaková, Helena Hronská, Peter Gemeiner, Michal Rosenberg   +4 more
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Mycobacterial Epoxide Hydrolase EphD Is Inhibited by Urea and Thiourea Derivatives

International Journal of Molecular Sciences, 2021
The genome of the human intracellular pathogen Mycobacterium tuberculosis encodes an unusually large number of epoxide hydrolases, which are thought to be involved in lipid metabolism and detoxification reactions needed to endure the hostile environment ...
Jan Madacki, M. Kopál, M. Jackson, Jana Korduláková   +3 more
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Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Maternal exposure to high levels of the herbicide glyphosate may increase the risk for autism spectrum disorder (ASD) in offspring; however, the underlying mechanisms remain largely unknown.
Yaoyu Pu, Jun Yang, Lijia Chang, Y. Qu, Siming Wang, Kai Zhang, Zhongwei Xiong, Jiancheng Zhang, Yunfei Tan, Xingming Wang, Yuko Fujita, T. Ishima, Debin Wang, S. Hwang, B. Hammock, K. Hashimoto   +15 more
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An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease

Science Translational Medicine, 2020
Blocking epoxide hydrolase with a bioavailable small-molecule inhibitor reduces neuropathology in an Alzheimer’s disease mouse model. Dialing up epoxy fatty acids in the brain Neuroinflammation is strongly implicated in Alzheimer’s disease (AD).
A. Ghosh, Michele M. Comerota, Debin Wan, Fading Chen, Nicholas E. Propson, S. Hwang, B. Hammock, Hui Zheng   +7 more
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Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products.

Journal of Medicinal Chemistry, 2020
Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and ...
Chengpeng Sun, Xin-Yue Zhang, C. Morisseau, S. Hwang, Zhanjun Zhang, B. Hammock, Xiaochi Ma   +6 more
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Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Defective intestinal barrier function and enhanced lipopolysaccharide (LPS)/bacterial translocation is a key pathogenic factor in many human diseases, including obesity. To date, the molecular mechanisms leading to intestinal barrier defects
Yuxin Wang, Jun Yang, Weicang Wang, Katherine Z. Sanidad, Maris A. Cinelli, Debin Wan, S. Hwang, Daeyoung Kim, K. S. Lee, Hang Xiao, B. Hammock, Guodong Zhang   +11 more
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