Results 41 to 50 of about 101,558 (168)

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

The FEBS Journal, EarlyView.
Neurodegeneration is thought to arise due to the disruption of the protein homeostasis. In synucleinopathies, alterations in the levels of functional and aggregated aSyn lead to proteinopenia and proteinopathy, respectively. aSyn and β‐glucocerebrosidase are closely linked to lipid metabolism, impacting organelle function and lipidostasis.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Molecular changes in agroinfiltrated leaves of Nicotiana benthamiana expressing suppressor of silencing P19 and coronavirus‐like particles

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana. Relying on bacterial vector Agrobacterium tumefaciens, this process is favoured by co‐expression of viral silencing suppressor
Louis‐Philippe Hamel, Francis Poirier‐Gravel, Marie‐Ève Paré, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Dominique Michaud, Marc‐André D'Aoust   +9 more
wiley   +1 more source

Human liver cytosolic epoxide hydrolases [PDF]

European Journal of Biochemistry, 1988
Human liver epoxide hydrolases were characterized by several criteria and a cytosolic cis‐stilbene oxide hydrolase (cEHcso) was purified to apparent homogeneity.Styrene oxide and five phenylmethyloxiranes were tested as substrates for human liver epoxide hydrolases.
Ludwig Schladt, Helmut Thomas, Franz Oesch, Renate Hartmann   +3 more
openaire   +3 more sources

Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.

British Journal of Clinical Pharmacology, 2016
AIMS Endothelial-derived epoxyeicosatrienoic acids may regulate vascular tone and are metabolized by soluble epoxide hydrolase enzymes (sEH). GSK2256294 is a potent and selective sEH inhibitor that was tested in two phase I studies.
A. Lazaar, Lucy Yang, R. Boardley, N. Goyal, Jonathan Robertson, S. Baldwin, D. Newby, I. Wilkinson, R. Tal-Singer, R. Mayer, J. Cheriyan   +10 more
semanticscholar   +1 more source

Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease

Experimental Physiology, EarlyView.
Abstract Adipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipose tissue‐mediated autocrine, paracrine and endocrine signalling and inter‐organ communication. Traditionally seen as passive entities, metabolites
Anna Malicka, Aysha Ali, Amanda D. V. MacCannell, Lee D. Roberts   +3 more
wiley   +1 more source

Unveiling New Triazoloquinoxaline‐Based PROTACs Designed for the Selective Degradation of the ncBAF Chromatin Remodeling Subunit BRD9

Chemistry – A European Journal, Volume 31, Issue 34, June 17, 2025.
We present new BRD9‐targeting degraders featuring a chemical warhead and E3 ligase ligand that distinctly differ from the typical chemical units used for BRD9 degradation. Specifically, we identified two VHL‐based PROTACs (2 and 9) based on a [1,2,4]triazolo[4,3‐a]quinoxaline scaffold that effectively and selectively degrade BRD9 and exhibit ...
Martina Pierri, Guglielmo Bove, Erica Gazzillo, Ester Colarusso, Francesca Scala, Giacomo Pepe, Stefania Terracciano, Maria Giovanna Chini, Nicla Simonelli, Ines Bruno, Angela Nebbioso, Pietro Campiglia, Giuseppe Bifulco, Lucia Altucci, Nunzio Del Gaudio, Gianluigi Lauro   +15 more
wiley   +1 more source

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase reduces brain damage and attenuates neuroinflammation after intracerebral hemorrhage

Journal of Neuroinflammation, 2017
Inflammatory responses significantly contribute to neuronal damage and poor functional outcomes following intracerebral hemorrhage (ICH). Soluble epoxide hydrolase (sEH) is known to induce neuroinflammatory responses via degradation of anti-inflammatory ...
Chun-Hu Wu, S. Shyue, T. Hung, Shin Wen, Chao-Chang Lin, Che-Feng Chang, Szu-Fu Chen   +6 more
semanticscholar   +1 more source

Novel Nano-/Micro-Biocatalyst: Soybean Epoxide Hydrolase Immobilized on UiO-66-NH2 MOF for Efficient Biosynthesis of Enantiopure (R)-1, 2-Octanediol in Deep Eutectic Solvents

, 2016
The nano-/microscale UiO-66-NH2 metal–organic framework (MOF) materials were successfully prepared with a uniform size of about 350–400 nm and structurally characterized.
Shi-Lin Cao, Dong Yue, Xuehui Li, T. Smith, Ning Li, Min-hua Zong, Hong Wu, Yongzheng Ma, Wenyong Lou   +8 more
semanticscholar   +1 more source

Nanobody Based Immunoassay for Human Soluble Epoxide Hydrolase Detection Using Polymeric Horseradish Peroxidase (PolyHRP) for Signal Enhancement: The Rediscovery of PolyHRP?

Analytical Chemistry, 2017
Soluble epoxide hydrolase (sEH) is a potential pharmacological target for treating hypertension, vascular inflammation, cancer, pain, and multiple cardiovascular related diseases.
Dongyang Li, Yongliang Cui, C. Morisseau, S. Gee, Candace S. Bever, Xiangjiang Liu, Jian Wu, B. Hammock, Y. Ying   +8 more
semanticscholar   +1 more source

Catalysis With Deep Eutectic Solvents: Challenges and Opportunities

ChemCatChem, Volume 17, Issue 11, June 6, 2025.
Deep eutectic solvents (DESs) are emerging as sustainable alternatives in catalysis, offering tunable properties for diverse chemical transformations. This review explores the dual role of DESs as solvents and catalysts, highlighting advancements in organic chemistry, materials science, CO2 fixation, biomass valorization, polymer degradation, and ...
Eduardo Guzmán
wiley   +1 more source