Results 61 to 70 of about 11,968 (183)

Co‐Detoxification of Multiple Mycotoxins: Microbial and Enzymatic Biodegradation Processes

Food Frontiers, Volume 7, Issue 4, July 2026.
The presence of mycotoxins poses a threat to food safety. This article reviews microbial/enzymatic detoxification technologies and the main degradation pathways of key mycotoxins. We propose to overcome current bottlenecks through enzyme engineering and synthetic biology, providing a roadmap for sustainable and scalable solutions.
Lixia Fan, Changying Guo, Saranya Poapolathep, Amnart Poapolathep, Mingxiao Ning, Bingchun Zhang, Xianfeng Ren, Antonio F. Logrieco   +7 more
wiley   +1 more source

Tracking COVID‐19 Severity and Progression Through Amines and Lipid Mediators

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) exhibits a broad spectrum of severity, ranging from mild to critical cases. To reduce mortality and costs, tailored early interventions for at‐risk patients are essential. This study elucidates the association between longitudinal metabolomic profiles and COVID‐19 severity and progression.
Melissa Goris, Merys Valdez, Lieke Lamont, Wei Yang, Amy Harms, Naama Karu, Sabine Bos, Jelte Geerlings, Tom Ottenhoff, Roula Tsonaka, Anna HE Roukens, M. Sesmu Arbous, Simone A. Joosten, Thomas Hankemeier, Alida Kindt, In collaboration with BEAT‐COVID group, M.S. Arbous, B.M. van den Berg, S. Cannegieter, C.M. Cobbaert, A. van der Does, J.J.M. van Dongen, J. Eikenboom, M.C.M. Feltkamp, A. Geluk, J.J. Goeman, M. Giera, T. Hankemeier, M.H.M. Heemskerk, P.S. Hiemstra, C.H. Hokke, J.J. Janse, S.P. Jochems, S.A. Joosten, M. Kikkert, L. Lamont, J. Manniën, T.H.M. Ottenhoff, M.R. del Prado, N. Queralt Rosinach, M. Roestenberg, M. Roos, A.H.E. Roukens, H.H. Smits, E.J. Snijder, F.J.T. Staal, L.A. Trouw, R. Tsonaka, A. Verhoeven, L.G. Visser, J.J.C. de Vries, D.J. van Westerloo, J. Wigbers, H.J. van der Wijk, R.C. van Wissen, M. Wuhrer, M. Yazdanbakhsh, M. Zlei   +57 more
wiley   +1 more source

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

IUCrJ, 2018
The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenylpropane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product ...
Åsa Janfalk Carlsson, Paul Bauer, Doreen Dobritzsch, Shina C. L. Kamerlin, Mikael Widersten   +4 more
doaj   +1 more source

Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection

mBio, 2016
Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman, Varun K. Dalmia, Daniel E. Goldberg   +2 more
doaj   +1 more source

epoxide hydrolase

Citation: 'epoxide hydrolase' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.10676 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +2 more sources

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +1 more source

The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

Frontiers in Pharmacology
Arachidonic acid (AA) has three main metabolic pathways: the cycloxygenases (COXs) pathway, the lipoxygenases (LOXs) pathway, and the cytochrome P450s (CYPs) pathway. AA produces epoxyeicosatrienoic acids (EETs) through the CYPs pathway.
Shan Jiang, Shan Jiang, Siyi Han, Dao Wen Wang, Dao Wen Wang   +4 more
doaj   +1 more source

Soluble epoxide hydrolase in the human placenta throughout gestation

Taiwanese Journal of Obstetrics & Gynecology, 2019
Objective: To investigate the spatial and temporal changes of soluble epoxide hydrolase (sEH) in the human placenta throughout gestation and to study the effects of hypoxia-reoxygenation (HR) on the expression of sEH in villous explants in vitro ...
Tai-Ho Hung, Szu-Fu Chen, T'sang-T'ang Hsieh   +2 more
doaj   +1 more source

Comprehensive analysis of the immune implication of EPHX4 gene in laryngeal squamous cell carcinoma

Brazilian Journal of Otorhinolaryngology
Objectives: The role of Epoxide Hydrolase-4 (EPHX4), a member of epoxide hydrolase family, has not been investigated in cancer. The purpose of this article is to explore the application value of EPHX4 in laryngeal cancer and its relationship with immune ...
Nimei Shen, Gang Gao, Xinhong Lu, Jiaxin Jin, Liwei Lin, Maohua Qian, Yang Qin   +6 more
doaj   +1 more source

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

Journal of Lipid Research, 1974
The formation of 5α,6α- and 5β,6β-epoxides of cholesterol and β-sitosterol in rat liver subcellular fractions has been studied. The results show that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols ...
Leif Aringer, Peter Eneroth
doaj   +1 more source