Results 61 to 70 of about 67,478 (222)
Role of soluble epoxide hydrolase in pain and depression comorbidity
Neurobiology of DiseaseThe coexistence of chronic pain and depression in clinical practice places a substantial social burden and profoundly impacts in patients. Although a clear correlation exists, the underlying mechanism of comorbidity between chronic pain and depression ...
Yuchen Bu +6 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto +7 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley +1 more source
Soluble Epoxide Hydrolase Hepatic Deficiency Ameliorates Alcohol-Associated Liver Disease
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies.
Aline Mello +9 more
doaj +1 more source
Synthesis of Microbial‐Derived Octadecanoids
Lipids, EarlyView.C18‐carbon containing dietary polyunsaturated fatty acids (e.g., linoleic acid, α‐linolenic acid, and γ‐linolenic acid) are metabolized by bacteria in the gut into oxygenated lipid mediators termed octadecanoids. To study the biological function of these compounds, we report here the chemical synthesis of multiple octadecanoids.
Johanna Revol‐Cavalier +6 more
wiley +1 more source
Localization of microsomal epoxide hydrolase in normal and neoplastic human kidney.
, 1995 Microsomal epoxide hydrolase is a xenobiotic metabolizing enzyme that catalyzes the conversion of toxic and carcinogenic epoxides to less toxic dihydrodiols.
J A McKay +5 more
core +1 more source
The crystal structure of mycobacterial epoxide hydrolase A [PDF]
, 2020 The human pathogen Mycobacterium tuberculosis is the causative agent of tuberculosis resulting in over 1 million fatalities every year, despite decades of research into the development of new anti-TB compounds. Unlike most other organisms M. tuberculosis
Fischer, M. +17 more
core +1 more source
Polycyclic compounds as soluble epoxide hydrolase inhibitors
Invention DisclosureIn this invention, a novel family of benzohomoadamantane-based soluble epoxide hydrolase inhibitors is disclosed. The benzohomoadamantane scaffold is a polycyclic, readily accessible, system that features a homoadamantane unit fused with an aromatic ring.
S. Codony +5 more
doaj +1 more source
Inhibition of Soluble Epoxide Hydrolase for Renal Health
Frontiers in Pharmacology, 2019 A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates.
Jun-Yan Liu, Jun-Yan Liu
doaj +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley +1 more source