Results 81 to 90 of about 67,478 (222)
Disrupting Dimerization Translocates Soluble Epoxide Hydrolase to Peroxisomes.
PLoS ONE, 2016 The epoxyeicosatrienoic acid (EET) neutralizing enzyme soluble epoxide hydrolase (sEH) is a neuronal enzyme, which has been localized in both the cytosol and peroxisomes.
Jonathan W Nelson +3 more
doaj +1 more source
Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova +3 more
wiley +1 more source
Photobiocatalytic Linear Deracemization of β‐Hydroxynitriles
ChemSusChem, Volume 19, Issue 19, 14 October 2026.Photosensitizers were screened for the oxidation of β‐hydroxynitriles under blue light irradiation, finding tetra‐n‐butyl decatungstate as the most suitable catalyst for accessing ketonitriles. Subsequently, bioreductions were carried out, leading to the identification of stereocomplementary alcohol dehydrogenases for the development of a linear ...
Sara Filgueira +2 more
wiley +1 more source
Discovery of potent non-urea inhibitors of soluble epoxide hydrolase
, 2009 A class of potent non-urea inhibitors of soluble epoxide hydrolase was discovered via high throughput screening and SARs-guided modification. Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A
Yan, Fang +16 more
core +1 more source
Recombinant proteins of epoxide hydrolase (eh) from peach
, 2010 The description relates to the production of three epoxide hydrolase (EH) recombinant proteins derived from peach (Prunus persica) in bacterial cells, purification methods thereof and uses thereof in enantioselective reactions, in particular, on ...
C.M. Pozzi, C. Ortugno, A. Vecchietti
core +2 more sources
Inhibition of Soluble Epoxide Hydrolase Reduces Paraquat Neurotoxicity in Rodents [PDF]
, 2022 Paraquat is one of the most common and acutely toxic herbicides used in developing nations, with epidemiological studies linking chronic paraquat exposure to Parkinson’s disease.
Atone, Jogen
core +1 more source
Advanced Science, Volume 13, Issue 59, 23 October 2026.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
, 1986 The present studies identify the steric factors involved in the hydration of epoxide intermediates of some pesticides by hepatic epoxide hydrolase.
D. Cova +3 more
core +1 more source
Epilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer +7 more
wiley +1 more source
Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme
IUCrJ, 2018 The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenylpropane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product ...
Åsa Janfalk Carlsson +4 more
doaj +1 more source