Results 91 to 100 of about 67,478 (222)

Panax notoginseng Saponins Accelerate Diabetic Wound Repair by Minimizing Mitochondrial Dysfunction and Inhibiting Pyroptosis of Macrophage via Regulating Ephx2/11,12‐EET Axis

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
Panax notoginseng saponins (PNS) accelerate diabetic wound healing via targeting the Ephx2/11,12‐EET axis in macrophages. PNS inhibits Ephx2 expression to elevate 11,12‐EET levels, which restores mitochondrial homeostasis by regulating mitochondrial dynamic proteins, reduces mtROS production, and subsequently suppresses NLRP3 inflammasome‐mediated ...
Nan Chen, Bo Zhu, Cai‐hua Sun, Tong Hou   +3 more
wiley   +1 more source

Proteomic Analysis of Three Independent Series of Sequential Cystic Fibrosis Strains in an International Pseudomonas aeruginosa Reference Panel Indicates Positive Selection in Late Infection Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Comparison of proteomes from three series of sequential Pseudomonas aeruginosa isolates from people with cystic fibrosis identified eleven proteins with increased abundance in at least one late isolate per patient. Three proteins were increased in all five late isolates, and the probability of this occurring by chance is 5.06 × 10−53, indicating strong
Joanna Drabinska, Lucia O'Connor, Caoilin McClean, Siobhán McClean   +3 more
wiley   +1 more source

Cloning and characterization of an epoxide hydrolase-encoding gene from Rhodotorula glutinis

, 2000
We cloned and characterized the epoxide hydrolase gene, EPH1, from Rhodotorula glutinis. The EPH1 open reading frame of 1230 bp was interrupted by nine introns and encoded a polypeptide of 409 amino acids with a calculated molecular mass of 46.3 kDa. The
Bont, J.A.M., de, Verdoes, J.C., Vreugdenhil, S., Visser, H.   +3 more
core   +1 more source

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy [PDF]

, 2017
A product of the soluble epoxide hydrolase enzyme, 19,20-dihydroxydocosapentaenoic acid (19,20-DHDP), is implicated in the pathogenesis of diabetic retinopathy; levels of 19,20-DHDP increase in the retinas of mice and humans with diabetes, and inhibition
Charles G. Eberhart, Devraj, Kavi, Andreas Jungmann, Clemens Glaubitz, Fauser, Sascha, Fleming, Ingrid, Cheng, Zhixing, Dziumbla, Sarah, Sarah Dziumbla, Liya Wang, Jungmann, Andreas, Kavi Devraj, Akrit Sodhi, Awwad, Khader, Liebner, Stefan, Bruce D. Hammock, Hammes, Hans-Peter, Popp, Rüdiger, de Mos, Julian, Julian de Mos, Sodhi, Akrit, Eberhart, Charles G, Glaubitz, Clemens, Hans-Peter Hammes, Sven Zukunft, Ingrid Fleming, Hammock, Bruce D, Lin, Jihong, Oliver J. Müller, Jiong Hu, Zukunft, Sven, Frömel, Timo, Timo Frömel, Stefan Liebner, Rüdiger Popp, Hu, Jiong, Khader Awwad, Sofia-Iris Bibli, Zhixing Cheng, Müller, Oliver J, Jihong Lin, Sascha Fauser, Bibli, Sofia-Iris, Wang, Liya   +43 more
core   +1 more source

Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection

mBio, 2016
Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs). EETs function as vasodilators and anti-inflammatory modulators in the bloodstream.
Natalie J. Spillman, Varun K. Dalmia, Daniel E. Goldberg   +2 more
doaj   +1 more source

Flavonoids as Modulators of Lipid Mediator Signaling: A Narrative Review on Mechanisms, Current Evidence, and Gaps in the Literature

Molecular Nutrition &Food Research, Volume 70, Issue 20, 28 October 2026.
Flavonoid consumption may modulate phospholipase activity and COX‐, LOX‐, and CYP450‐dependent oxylipin biosynthesis, reshaping lipid mediator networks. Emerging evidence suggests these shifts may favor inflammatory resolution over propagation, with implications for metabolic, cardiovascular, and neuroinflammatory disease risk.
Joseph Arballo, Mary Ann Lila
wiley   +1 more source

EH3 (ABHD9): the first member of a new epoxide hydrolase family with high activity for fatty acid epoxides

Journal of Lipid Research, 2012
Epoxide hydrolases are a small superfamily of enzymes important for the detoxification of chemically reactive xenobiotic epoxides and for the processing of endogenous epoxides that act as signaling molecules.
Martina Decker, Magdalena Adamska, Annette Cronin, Francesca Di Giallonardo, Julia Burgener, Anne Marowsky, John R. Falck, Christophe Morisseau, Bruce D. Hammock, Artiom Gruzdev, Darryl C. Zeldin, Michael Arand   +11 more
doaj   +1 more source

Coumarin‐Benzimidazole Hybrids as Multitarget Scaffolds for Antileishmanial Drug Discovery

ChemistrySelect, Volume 11, Issue 38, 13 October 2026.
Coumarin‐benzimidazole hybrids emerge as promising antileishmanial agents through virtual screening against essential Leishmania enzymes, Cathepsin B (CatB), and N‐myristoyltransferase (NMT). Molecular docking and dynamics simulations reveal highly stable target interactions that surpass the reference drug miltefosine (MTF).
Fernanda Melo Jucá, Damião Sampaio de Sousa, Caio Henrique Alexandre Roberto, Márcia Machado Marinho, Emmanuel Silva Marinho   +4 more
wiley   +1 more source

Biocatalytic preparation of chiral epichlorohydrins using recombinant Pichia pastoris expressing epoxide hydrolase of Rhodotorula glutinis

, 2004
The use of enantioselective hydrolysis for preparing chiral epichlorohydrins was investigated using recombinant Pichia pastoris with the enantioselective epoxide hydrolase of Rhodotorula glutinis.
Lee, Jae-Hwa, Kim, Hee Sook, Lee, Eun Yeol, Park, Sunghoon   +3 more
core   +1 more source

The involvement of soluble epoxide hydrolase in the development of cardiovascular diseases through epoxyeicosatrienoic acids

Frontiers in Pharmacology
Arachidonic acid (AA) has three main metabolic pathways: the cycloxygenases (COXs) pathway, the lipoxygenases (LOXs) pathway, and the cytochrome P450s (CYPs) pathway. AA produces epoxyeicosatrienoic acids (EETs) through the CYPs pathway.
Shan Jiang, Shan Jiang, Siyi Han, Dao Wen Wang, Dao Wen Wang   +4 more
doaj   +1 more source