Results 71 to 80 of about 67,478 (222)

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium

, 2017
Epoxide hydrolase (EH) enzymes catalyze the hydration of racemic epoxides to yield their corresponding vicinal diols. In this work, the Bacillus megaterium epoxide hydrolase (BmEH)-mediated hydrolysis of racemic styrene oxide (rac-SO) and its para-nitro ...
Serrano Hervás, Eila, Osuna Oliveras, Sílvia, Eila Serrano-Hervás, Garcia Borràs, Marc, Marc Garcia-Borràs, Sílvia Osuna   +5 more
core   +1 more source

Gene evolution of epoxide hydrolases and recommended nomenclature [PDF]

, 1995
We have analyzed amino acid sequence relationships among soluble and microsomal epoxide hydrolases, haloacid dehalogenases, and a haloalkane dehalogenase.
Shinozaki, K, Hammock, B D, Oesch, F, Kiyosue, T, Grant, D, Arand, Michael; https://orcid.org/, Beetham, J K, Pinot, F, Garbarino, J, Belknap, W R   +9 more
core   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

KINETIC RESOLUTION BY EPOXIDE HYDROLASE CATALYZED HYDROLYSIS OF RACEMIC METHYL-SUBSTITUTED METHYLENECYCLOHEXENE OXIDES

, 1995
A complete kinetic resolution of 2,2-dimethylmethylenecyclobexene oxide and a partial resolution of the cis and trans-2-methylmethylenecyclohexene oxides, but not of their 3-methyl substituted isomers, have been achieved by partial hydrolysis to the ...
BELLUCCI G, ROSINI C., INGROSSO G, CHIAPPE, CINZIA   +3 more
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Soluble Epoxide Hydrolase Dimerization Is Required for Hydrolase Activity [PDF]

Journal of Biological Chemistry, 2013
Soluble epoxide hydrolase (sEH) plays a key role in the metabolic conversion of the protective eicosanoid 14,15-epoxyeicosatrienoic acid to 14,15-dihydroxyeicosatrienoic acid. Accordingly, inhibition of sEH hydrolase activity has been shown to be beneficial in multiple models of cardiovascular diseases, thus identifying sEH as a valuable therapeutic ...
Jonathan W, Nelson, Rishi M, Subrahmanyan, Sol A, Summers, Xiangshu, Xiao, Nabil J, Alkayed   +4 more
openaire   +2 more sources

Patterns of epoxide metabolism by epoxide hydrolase and glutathione S-transferase associated with age and genotype in Drosophila melanogaster

, 1987
Epoxide hydrolase and glutathione S-transferase activities toward trans- and cis-stilbene oxides were measured in 3 strains of Drosophila melanogaster. Differences in age dependence, substrate selectivity and subcellular location were detected suggesting
Harshman, L. G., Ottea, J. A., Hammock, B.   +2 more
core   +1 more source

Insights into the potential role of sEH inhibition in the prevention and progression of neurological disorders

Endocrine and Metabolic Science
Neurological disorders are associated with decreased blood supply to the brain, neuronal damage, oxidative stress, and inflammation. While treatments are limited, soluble epoxide hydrolase inhibitors can be useful in alleviating neurological disorders ...
Mamatha Gavisiddaiah, Sumanta Kumar Goswami, Manali Somanna, Bruce D. Hammock, Kenganora Mruthunjaya, Abigail Fielding, Dithu Thekkekkara, Santhepete Nanjundaiah Manjula   +7 more
doaj   +1 more source

Pangenomic framework for globe artichoke supports SNP‐based varietal fingerprinting

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Globe artichoke (Cynara cardunculus var. scolymus L.) comprises a broad range of local ecotypes and varietal groups whose genetic diversity has been investigated through different molecular markers. However, recent advances in next‐generation sequencing and pangenomic approaches provide new opportunities to capture genome‐wide variation at ...
Ezio Portis, Edoardo Vergnano, Luciana Gaccione, Alberto Acquadro, Cinzia Comino, Cristiano Carli, Lorenzo Barchi, Matteo Martina   +7 more
wiley   +1 more source