Results 51 to 60 of about 14,919 (226)

Cholesterol epoxide hydrolase and cancer

Current Opinion in Pharmacology, 2012
Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol. ChEH is a hetero-oligomeric complex called the anti-estrogen binding site (AEBS) comprising 3β-hydroxysterol-Δ(8)-Δ(7)-isomerase (D8D7I) and 3β-hydroxysterol-Δ(7)-reductase (DHCR7).
Silvente-Poirot, Sandrine, Poirot, Marc
openaire   +3 more sources

Cervical epidural catheter for administration of detomidine and morphine in a model of carpal synovitis in the horse

Veterinary Surgery, EarlyView.
Abstract Objective To determine the analgesic effects of detomidine and morphine administered by cervical epidural catheter (CEC) on a model of thoracic limb pain. Study design Prospective, randomized, blinded crossover study. Animals Five adult horses.
Veronica L. Edwards, Rachel Reed, Michael Perlini, Valerie J. Moorman   +3 more
wiley   +1 more source

Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology [PDF]

Physiological Reviews, 2012
Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly contribute to vascular and cardiac physiology. The contribution of EETs to vascular and cardiac function is further influenced by soluble epoxide hydrolase (sEH) that degrades EETs to diols. Vascular actions of EETs include dilation and angiogenesis.
openaire   +2 more sources

Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Their bioactive constituents act through antioxidant, anti‐inflammatory, and metabolic‐regulating mechanisms, validating their classification as functional foods. Evidence from clinical and biochemical studies largely supports these benefits, although some claims stem from preliminary or in vitro findings.
Nighat Raza, Alina Sadaf, Reeha Mushtaq, Mirza Abid Mehmood, Luqman Amrao, Fakhar Islam, Muhammad Afzaal, Mohd Asif Shah   +7 more
wiley   +1 more source

Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

Molecular Pain, 2011
Background Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers.
Brandes Ralf P, Fleming Ingrid, Angioni Carlo, Fischer Michael J, Altenrath Kai, Coste Ovidiu, Sisignano Marco, Brenneis Christian, Reeh Peter W, Woolf Clifford J, Geisslinger Gerd, Scholich Klaus   +11 more
doaj   +1 more source

Catalysis of potato epoxide hydrolase, StEH1 [PDF]

Biochemical Journal, 2005
The kinetic mechanism of epoxide hydrolase (EC 3.3.2.3) from potato, StEH1 (Solanum tuberosum epoxide hydrolase 1), was studied by presteady-state and steady-state kinetics as well as by pH dependence of activity. The specific activities towards the different enantiomers of TSO (trans-stilbene oxide) as substrate were 43 and 3 μmol·min−1·mg−1 with the ...
Lisa T, Elfström, Mikael, Widersten
openaire   +2 more sources

D‐Optimal Design for Enzymatic Ring‐Opening Polymerization of ε‐Caprolactone: Toward Sustainable Polyester Synthesis Using Biobased Solvents

Journal of Polymer Science, Volume 64, Issue 3, Page 817-824, 1 February 2026.
A D‐optimal design of experiments maps the influence of key reaction parameters on enzymatic ε‐caprolactone polymerization. Thus linking multivariate conditions to conversion, molar mass characteristics, and by‐product formation, whilst demonstrating that biobased solvents offer viable, sustainable media for polyester synthesis.
Emily G. Dixon, Emily Chau, Luisa Ciano, Anca Pordea, Karen Alvey, Vincenzo Taresco   +5 more
wiley   +1 more source

Sex‐dependent role of 20‐HETE synthesis in outcome from ischemic stroke in rats

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract The lipid mediator 20‐HETE is produced by ω‐hydroxylation of arachidonic acid mediated by cytochrome P450 (CYP) enzymes including CYP4A, which has four distinct isoforms in rodents. Several laboratories demonstrated that 20‐HETE synthesis inhibition reduces infarct volume following middle cerebral artery occlusion (MCAO) in male animals. Here,
Rongrong Zhang, Yanrong Shi, Suyi Cao, Raymond C. Koehler, Zeng‐Jin Yang   +4 more
wiley   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Insights into the potential role of sEH inhibition in the prevention and progression of neurological disorders

Endocrine and Metabolic Science
Neurological disorders are associated with decreased blood supply to the brain, neuronal damage, oxidative stress, and inflammation. While treatments are limited, soluble epoxide hydrolase inhibitors can be useful in alleviating neurological disorders ...
Mamatha Gavisiddaiah, Sumanta Kumar Goswami, Manali Somanna, Bruce D. Hammock, Kenganora Mruthunjaya, Abigail Fielding, Dithu Thekkekkara, Santhepete Nanjundaiah Manjula   +7 more
doaj   +1 more source