Results 151 to 160 of about 15,949 (256)

Fluorinated Iminosugar Glycomimetics: Synthesis and Activity as GCase Ligands

European Journal of Organic Chemistry, EarlyView.
DAST‐mediated deoxyfluorination of suitably functionalized piperidines provided regio‐ and stereoselective access to fluorinated piperidine and pyrrolidine glycomimetics, the latter arising from an unusual ring‐contraction process. Fluorination generally enhanced β‐glucocerebrosidase (GCase) inhibitory potency, but lost PC activity toward L444P/L444P ...
Francesca Mangiavacchi, Alessio Morano, Cosimo Margheri, Cristina Faggi, Amelia Morrone, Camilla Matassini, Francesca Clemente, Andrea Goti, Martina Cacciarini, Francesca Cardona   +9 more
wiley   +1 more source

Carbon‐Supported Catalytic Systems Assembled by π–π Interactions

European Journal of Organic Chemistry, EarlyView.
This review explores the noncovalent immobilization of organic and organometallic catalysts on carbonaceous supports through π–π interactions, highlighting its potential to enhance catalyst recovery, recyclability, and the sustainability of organic synthesis.
Chloé Jamalkhan, Léa Ibos, Sarah Bouery, Veronika Myronova, Anaïs Scuiller, Mohamed Mellah, David Kreher, Emmanuelle Schulz, Olivier R. P. David   +8 more
wiley   +1 more source

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Graphene oxide/exfoliated black phosphorus van der Waals heterojunctions for PEDOT:PSS‐free‐based organic light‐emitting diodes achieving excellent electroluminescence performance

FlexMat, EarlyView.
A novel two‐dimensional heterojunction assembled from graphene oxide and exfoliated black phosphorus via van der Waals interactions is proposed to replace widely used poly(3,4‐ethylenedioxythiophene)‐polystyrene sulfonate for efficient hole injection layer in organic light‐emitting diodes, achieving impressive electroluminescence performance.
Yuefeng Li, Xiaozhen Wei, Ruihao Yang, Shuyu Li, Jingkun Wang, Min Zhao, Yanqin Miao, Yuying Hao, Hua Wang, Kunping Guo   +9 more
wiley   +1 more source

Citrus Essential Oils in Food Safety and Health: Advances in AI‐Assisted Authentication, Antimicrobial Applications, Sustainable Extraction, and Regulatory Translation

Food Safety and Health, EarlyView.
Citrus essential oils combine sustainable extraction, AI‐assisted authentication, multi‐omics profiling, antimicrobial activity, and regulatory safety to enhance food quality, detect adulteration, and promote consumer health, and support intelligent, sustainable food systems through innovative industrial applications and circular bioeconomy strategies.
Md. Hassan Bin Nabi, Liza Akter, Yusuf Chowdhury, Mohima Akther Any, Nazmul Islam, Erni Sofia Murtini, Nurul Huda, Wahidu Zzaman   +7 more
wiley   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

Modular Synthesis of C5 Sulfur‐Functionalized Oxazolidinones via Thiol‐Induced Cascade Reactions of Epoxy Carbamates

Journal of the Chinese Chemical Society, EarlyView.
A modular cascade reaction of epoxy carbamates with diverse thiols provides efficient access to C5 sulfide‐functionalized oxazolidinones. Intermolecular nucleophilic epoxide ring opening followed by intramolecular acyl substitution enables simultaneous sulfur installation and oxazolidinone formation.
Cheng‐Kun Lin, Yu‐Jin Huang, Meng‐Hsia Tsai, Yueh‐Ling Huang, Xsing‐Yi Lee, Hui‐Yin Hsu   +5 more
wiley   +1 more source

Unveiling chemical composition of peppermint oil and its bioactivities compared with (R)‐(+)‐limonene: antimicrobial, antibiofilm, and insecticidal perspectives

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Peppermint (Mentha piperita L.) essential oil (MPEO) is recognized for its broad‐spectrum antimicrobial properties and potential applications in food preservation. This study aimed to determine whether the bioactivity of MPEO is attributable to (R)‐(+)‐limonene or whether the complete essential oil provides higher efficacy due to ...
Miroslava Kačániová, Stefania Garzoli, Minhang Qiao, Zhaojun Ban, Li Li, Jian Lou, Joel Horacio Elizondo‐Luevano, Wissem Mnif, Alessandro Bianchi, Rania Ben Saad, Anis Ben Hsouna   +10 more
wiley   +1 more source

Synthesis of Microbial‐Derived Octadecanoids

Lipids, EarlyView.
C18‐carbon containing dietary polyunsaturated fatty acids (e.g., linoleic acid, α‐linolenic acid, and γ‐linolenic acid) are metabolized by bacteria in the gut into oxygenated lipid mediators termed octadecanoids. To study the biological function of these compounds, we report here the chemical synthesis of multiple octadecanoids.
Johanna Revol‐Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E. Wheelock   +6 more
wiley   +1 more source

Biobased Epoxidized Castor Oil Covalent Adaptable Networks Adhesives Reinforced with Recycled Carbon Fibers

Macromolecular Rapid Communications, EarlyView.
It is reported the design of biobased sustainable, smart, and functional adhesives achieved dispersing recycled carbon fibers into biobased epoxy monomer. ABSTRACT The development of sustainable, smart, and functional adhesives is crucial in advancing environmentally friendly materials.
Alberto Cellai, Rafael Turra Alarcon, Bernhard Sölle, Elisabeth Rossegger, Valentina Casalegno, Milena Salvo, Marco Sangermano   +6 more
wiley   +1 more source