Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials [PDF]
BMC Cardiovascular Disorders, 2005 Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J +3 more
doaj +5 more sources
A prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) for corrective spinal surgery [PDF]
BMC Surgery, 2010 Background Multilevel spinal fusion surgery has typically been associated with significant blood loss. To limit both the need for transfusions and co-morbidities associated with blood loss, the use of anti-fibrinolytic agents has been proposed.
Vaz Kenneth M +3 more
doaj +4 more sources
Epsilon-Aminocaproic Acid in Liver Transplantation: A Three-Year, Retrospective Review. [PDF]
J Anesth Clin Res, 2013 Whiteley JR +5 more
europepmc +2 more sources
Brazilian Oral Research, 2006 A histological study was conducted of the alveolar bone healing process following tooth extraction of dehydrated rats after the implantation of fibrin adhesive (TISSUCOL™) associated to previous irrigation of the wound with a 5% epsilon aminocaproic
Tetuo Okamoto +4 more
doaj +2 more sources
Interstitial plasmin activity with epsilon aminocaproic acid: temporal and regional heterogeneity. [PDF]
Ann Thorac Surg, 2010 Reust DL +8 more
europepmc +3 more sources
The effect of ε‐aminocaproic acid on blood product requirement, outcome and thromboelastography parameters in severely thrombocytopenic dogs [PDF]
Journal of Veterinary Internal Medicine, Volume 38, Issue 2, Page 1013-1021, March/April 2024.Abstract Background No treatment other than platelet administration is known to protect against spontaneous hemorrhage in thrombocytopenic dogs. Objectives Primary: determine if treatment with ε‐aminocaproic acid (EACA) decreases the requirement for blood transfusions and improves outcome in dogs with severe thrombocytopenia.
Johanna Wolf +3 more
wiley +3 more sources
Effect of epsilon aminocaproic acid on red-cell transfusion requirements in major spinal surgery. [PDF]
Spine (Phila Pa 1976), 2009 Berenholtz SM +11 more
europepmc +3 more sources
Repurposing tranexamic acid as an anticancer drug: a systematic review and meta-analysis [PDF]
Journal of Cancer Research and Clinical OncologyPurpose Drug repurposing may be an efficient strategy for identifying new cancer treatments. Tranexamic acid (TXA), an antifibrinolytic agent that affects the plasminogen-plasmin pathway, may have potential anticancer effects by influencing tumor cell ...
Karoline Assifuah Kristjansen +3 more
doaj +2 more sources
Reduction of bleeding after heart operations through the prophylactic use of epsilon-aminocaproic acid [PDF]
, 1996 Excessive postoperative bleeding after heart operations continues to be a source of morbidity. This prospective double-blind study evaluated epsilon-aminocaproic acid as an agent to reduce postoperative bleeding and investigated its mode of action.
Thomas J. Vander Salm +9 more
openalex +3 more sources
Differential effects of epsilon-aminocaproic acid and aprotinin on matrix metalloproteinase release in patients following cardiopulmonary bypass. [PDF]
J Cardiovasc Pharmacol, 2008 Dorman BH +7 more
europepmc +2 more sources