Results 41 to 50 of about 1,675 (190)

Aprotinin may increase mortality in low and intermediate risk but not in high risk cardiac surgical patients compared to tranexamic acid and ε-aminocaproic acid - a meta-analysis of randomised and observational trials of over 30.000 patients

, 2013
Background: To compare the effect of aprotinin with the effect of lysine analogues (tranexamic acid and ε-aminocaproic acid) on early mortality in three subgroups of patients: low, intermediate and high risk of cardiac surgery.
Meybohm, Patrick, Julia Nierhoff (385973), Herrmann, Eva, Nierhoff, Julia, Zacharowski, Kai, Kai Zacharowski, Eva Herrmann, Patrick Meybohm, Patrick Meybohm (20539), Eva Herrmann (139197), Julia Nierhoff, Kai Zacharowski (77285)   +11 more
core   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

The Effect of Epsilon-aminocaproic Acid in the Induction and Growth of Sarcomas by Benzo[a]pyrene

, 1964
Five mg of benzo[a]pyrene and 500 mg of epsilon-aminocaproic acid were injected subcutaneously three times, at the same site and at the same time, to 15 Wistar rats, while a control group was given benzpyrene alone.
Donato Fumarola, Vito Diomede-Fresa
core   +1 more source

Antifibrinolíticos e cirurgia cardíaca com circulação extracorpórea Antifibrinolíticos y cirugía cardíaca con circulación extracorpórea Antifibrinolytics and cardiac surgery with cardiopulmonary bypass

Revista Brasileira de Anestesiologia, 2007
JUSTIFICATIVA E OBJETIVOS: A cirurgia cardíaca é a especialidade cirúrgica que com mais freqüência está associada a sangramento, coagulopatia e necessidade de derivados de sangue.
Ari-Tadeu Lírio dos Santos, João Carlos Splettstosser, Paulo Warpechowski, Mariana Mariz Pinto Gaidzinski   +3 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Antifibrinolytics in liver surgery

Indian Journal of Anaesthesia, 2010
Hyperfibrinolysis, a known complication of liver surgery and orthotopic liver transplantation (OLT), plays a significant role in blood loss. This fact justifies the use of antifibrinolytic drugs during these procedures.
Jalpa Makwana, Saloni Paranjape, Jyotsna Goswami   +2 more
doaj   +1 more source

Assessing the Impact of the 2021 VWD Guidelines on the Diagnosis/Management of Low VWF Patients

Haemophilia, Volume 32, Issue 3, Page 772-778, May/June 2026.
ABSTRACT Introduction The 2021 ASH/ISTH/NHF/WFH VWD diagnosis guidelines recommend Type 1 VWD diagnoses for patients with (a) VWF <0.30 IU/mL or (b) ‘Low VWF’ 0.30–0.50 IU/mL with the presence of abnormal bleeding. This recommendation recategorizes ‘Low VWF’ patients with abnormal bleeding into Type 1 VWD.
Michael Dong, Joanna Larson, Sepideh Saroukhani, Miguel Escobar, Lakshmi Srivaths   +4 more
wiley   +1 more source

Group B Streptococcus hijacks the host plasminogen system to promote brain endothelial cell invasion. [PDF]

PLoS ONE, 2013
Group B Streptococcus (GBS) is the leading cause of meningitis in neonates. We have previously shown that plasminogen, once recruited to the GBS cell surface and converted into plasmin by host-derived activators, leads to an enhancement of bacterial ...
Vanessa Magalhães, Elva Bonifácio Andrade, Joana Alves, Adilia Ribeiro, Kwang Sik Kim, Margarida Lima, Patrick Trieu-Cuot, Paula Ferreira   +7 more
doaj   +1 more source

Epsilon-aminocaproic acid therapy in ulcerative colitis [PDF]

Gut, 1970
On the supposition that excessive fibrinolysis at the rectal mucosal level may contribute to the pathogenesis of ulcerative colitis, 11 patients with this condition, in whom rectal bleeding was the predominant feature, were given a course of epsilon-aminocaproic acid therapy.
R H, Salter, A E, Read
openaire   +2 more sources

Antisense reduction in NADP‐ME in the C4 species Flaveria bidentis alters stomatal sensitivity to intercellular [CO2]

New Phytologist, Volume 250, Issue 3, Page 1585-1597, May 2026.
Summary Stomata have the crucial role of balancing the uptake of CO2 for photosynthesis and water loss via transpiration by adjusting their aperture. In C3 plants, coordination between photosynthesis and stomatal conductance can be disrupted by mutations in Calvin–Benson–Bassham (CBB) cycle expression, but it is not clear whether the disruption of the ...
Emmanuel L. Bernardo, Cristina Rodrigues Gabriel Sales, Tianshu Sun, Johannes Kromdijk   +3 more
wiley   +1 more source