Results 51 to 60 of about 2,828,108 (149)

A prospective, randomized, double-blinded single-site control study comparing blood loss prevention of tranexamic acid (TXA) to epsilon aminocaproic acid (EACA) for corrective spinal surgery

BMC Surgery, 2010
Background Multilevel spinal fusion surgery has typically been associated with significant blood loss. To limit both the need for transfusions and co-morbidities associated with blood loss, the use of anti-fibrinolytic agents has been proposed.
Vaz Kenneth M, Errico Thomas J, Verma Kushagra, Lonner Baron S   +3 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

ions from metal‐cationized tetrapeptides containing β‐alanine, γ‐aminobutyric acid or ε‐aminocaproic acid residues

, 2008
Click on the DOI link below to access the article (may not be free).The presence and position of a single beta-alanine (betaA), gamma-aminobutyric acid (gammaABu) or epsilon-aminocaproic acid (Cap) residue has been shown to have a significant influence ...
Sila O. Ochola, Michael J. Van Stipdonk, Erach R. Talaty, Ochola, Sila O., Talaty, Erach R., Osburn, Sandra M., Sandra M. Osburn, Van Stipdonk, Michael J.   +7 more
core   +1 more source

A Case Report on the Surgical Extraction of a Third Molar in a Patient with Bernard–Soulier Syndrome, an Uncommon Disease

Indian Journal of Dental Sciences
We present a case of a patient with Bernard–Soulier syndrome (BSS) who had his impacted third mandibular molar surgically extracted. An uncommon congenital bleeding condition called BSS is inherited in an autosomal recessive fashion.
Ashish Kamboj, Chandan Mishra, Paras Angrish, S.S Chopra, Sunil Kumar Singh   +4 more
doaj   +1 more source

A study of the interaction between Helicobacter pylori and components of the human fibrinolytic system

Brazilian Journal of Medical and Biological Research, 2000
The interaction of plasminogen, tissue plasminogen activator (t-PA) and urokinase with a clinical strain of Helicobacter pylori was studied. Plasminogen bound to the surface of H. pylori cells in a concentration-dependent manner and could be activated to
A. Yarzábal, L. Avilán, K. Hoelzl, M. de Muñoz, J. Puig, I. Kansau   +5 more
doaj   +1 more source

Assessing the Impact of the 2021 VWD Guidelines on the Diagnosis/Management of Low VWF Patients

Haemophilia, Volume 32, Issue 3, Page 772-778, May/June 2026.
ABSTRACT Introduction The 2021 ASH/ISTH/NHF/WFH VWD diagnosis guidelines recommend Type 1 VWD diagnoses for patients with (a) VWF <0.30 IU/mL or (b) ‘Low VWF’ 0.30–0.50 IU/mL with the presence of abnormal bleeding. This recommendation recategorizes ‘Low VWF’ patients with abnormal bleeding into Type 1 VWD.
Michael Dong, Joanna Larson, Sepideh Saroukhani, Miguel Escobar, Lakshmi Srivaths   +4 more
wiley   +1 more source

The relative efficacy of antifibrinolytics in adolescent idiopathic scoliosis: a prospective randomized trial. [PDF]

, 2014
BACKGROUND: Antifibrinolytics can reduce intraoperative blood loss. The primary aim of this study was to determine the efficacy of intraoperative tranexamic acid, epsilon-aminocaproic acid, and placebo at reducing perioperative blood loss and the ...
Lonner, Baron S, Errico, Thomas, Dryer, Joseph, Huncke, Tessa, Verma, MD, Kushagra, Diefenbach, Chris, Boenigk, Kirstin, Hoelscher, Christian, Peters, Austin   +8 more
core   +1 more source

Antisense reduction in NADP‐ME in the C4 species Flaveria bidentis alters stomatal sensitivity to intercellular [CO2]

New Phytologist, Volume 250, Issue 3, Page 1585-1597, May 2026.
Summary Stomata have the crucial role of balancing the uptake of CO2 for photosynthesis and water loss via transpiration by adjusting their aperture. In C3 plants, coordination between photosynthesis and stomatal conductance can be disrupted by mutations in Calvin–Benson–Bassham (CBB) cycle expression, but it is not clear whether the disruption of the ...
Emmanuel L. Bernardo, Cristina Rodrigues Gabriel Sales, Tianshu Sun, Johannes Kromdijk   +3 more
wiley   +1 more source

Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrhagia.

, 1990
We describe a 42-year-old woman who developed superior sagittal and left transverse sinus thrombosis associated with prolonged epsilon-aminocaproic acid therapy for menorrhagia.
E Melamed, A Achiron, M Gornish
core   +1 more source

Immunochemistry of human Lp[a]: characterization of monoclonal antibodies that cross-react strongly with plasminogen.

Journal of Lipid Research, 1991
Forty different monoclonal antibodies were produced from hybridomas that were raised against human Lp[a]. Of these, 14 strongly cross-reacted with plasminogen on ELISA screening assays while 16 clearly did not and 10 were only marginally cross-reactive ...
MA Lafferty, AM Salamon, DC Usher
doaj   +1 more source