Results 31 to 40 of about 1,399 (158)

Efficacy and safety of using aminocaproic acid and tranexamic acid during the perioperative period for treating trochanteric fractures in elderly femurs

BMC Musculoskeletal Disorders, 2023
Background Tranexamic acid (TXA) has long been the antifibrinolytic hemostatic drug of choice for orthopedic surgery. In recent years, the hemostatic effect of epsilon aminocaproic acid (EACA) has gradually been recognized by orthopedic surgeons and has ...
Alimujiang Yusufu, Abuduwupuer Haibier, Zheng Ren, Qi Qin, Ziyi Zhang, Yuan Zhou, Jian Ran   +6 more
doaj   +1 more source

Hydrogel Adhesives for Gastrointestinal Perforation: Design Principles and Applications

Exploration, Volume 6, Issue 3, June 2026.
There are few reviews on hydrogel adhesives that comprehensively highlight the design principles, factors affecting adhesion, and applications for gastrointestinal (GI) perforation repair. This review outlines the mainstream design approaches of hydrogel adhesives via covalent and noncovalent molecular interactions, illustrating the underlying adhesive
Yudi Pang, Shuai Tian, Qinyu Han, Yulin Deng, Jiatao Zhang, Enqiang Linghu, Qianqian Chen, Zhimin Wang   +7 more
wiley   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, Volume 13, Issue 26, 8 May 2026.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Antifibrinolíticos e cirurgia cardíaca com circulação extracorpórea Antifibrinolíticos y cirugía cardíaca con circulación extracorpórea Antifibrinolytics and cardiac surgery with cardiopulmonary bypass

Revista Brasileira de Anestesiologia, 2007
JUSTIFICATIVA E OBJETIVOS: A cirurgia cardíaca é a especialidade cirúrgica que com mais freqüência está associada a sangramento, coagulopatia e necessidade de derivados de sangue.
Ari-Tadeu Lírio dos Santos, João Carlos Splettstosser, Paulo Warpechowski, Mariana Mariz Pinto Gaidzinski   +3 more
doaj   +1 more source

Assessing the Impact of the 2021 VWD Guidelines on the Diagnosis/Management of Low VWF Patients

Haemophilia, Volume 32, Issue 3, Page 772-778, May/June 2026.
ABSTRACT Introduction The 2021 ASH/ISTH/NHF/WFH VWD diagnosis guidelines recommend Type 1 VWD diagnoses for patients with (a) VWF <0.30 IU/mL or (b) ‘Low VWF’ 0.30–0.50 IU/mL with the presence of abnormal bleeding. This recommendation recategorizes ‘Low VWF’ patients with abnormal bleeding into Type 1 VWD.
Michael Dong, Joanna Larson, Sepideh Saroukhani, Miguel Escobar, Lakshmi Srivaths   +4 more
wiley   +1 more source

Perioperative use of Epsilon-aminocaproic acid in patients with the diagnosis of prostatic benign hyperplasia

Revista Cubana de Anestesiología y Reanimación, 2016
Introduction: To reduce intraoperative blood loss and the use of transfusion requirements, antifibrinolytic agents that repermeabilize a bleeding vessel are used.
Zaily Fuentes Díaz, Orlando Bismark Rodríguez Salazar, Sarah López Lazo   +2 more
doaj   +2 more sources

Antifibrinolytics in liver surgery

Indian Journal of Anaesthesia, 2010
Hyperfibrinolysis, a known complication of liver surgery and orthotopic liver transplantation (OLT), plays a significant role in blood loss. This fact justifies the use of antifibrinolytic drugs during these procedures.
Jalpa Makwana, Saloni Paranjape, Jyotsna Goswami   +2 more
doaj   +1 more source

Epsilon-aminocaproic acid therapy in ulcerative colitis [PDF]

Gut, 1970
On the supposition that excessive fibrinolysis at the rectal mucosal level may contribute to the pathogenesis of ulcerative colitis, 11 patients with this condition, in whom rectal bleeding was the predominant feature, were given a course of epsilon-aminocaproic acid therapy.
R H, Salter, A E, Read
openaire   +2 more sources

Antisense reduction in NADP‐ME in the C4 species Flaveria bidentis alters stomatal sensitivity to intercellular [CO2]

New Phytologist, Volume 250, Issue 3, Page 1585-1597, May 2026.
Summary Stomata have the crucial role of balancing the uptake of CO2 for photosynthesis and water loss via transpiration by adjusting their aperture. In C3 plants, coordination between photosynthesis and stomatal conductance can be disrupted by mutations in Calvin–Benson–Bassham (CBB) cycle expression, but it is not clear whether the disruption of the ...
Emmanuel L. Bernardo, Cristina Rodrigues Gabriel Sales, Tianshu Sun, Johannes Kromdijk   +3 more
wiley   +1 more source