Results 61 to 70 of about 1,675 (190)

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, Volume 14, Issue 31, December 8, 2025.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

The use of fibrinolysis inhibitors in cardiac surgery with cardiopulmonary bypass (literature review)

Вестник анестезиологии и реаниматологии
In cardiac surgery with cardiopulmonary bypass (CPB) is a common complication. The incidence of this complication in cardiac surgery patients is estimated at about 10%.
V. Yu. Medvedeva, K. N. Khrapov, A. A. Khryapa, K. Yu. Kankova   +3 more
doaj   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

The fibrinolytic system facilitates tumor cell migration across the blood-brain barrier in experimental melanoma brain metastasis

BMC Cancer, 2006
Background Patients with metastatic tumors to the brain have a very poor prognosis. Increased metastatic potential has been associated with the fibrinolytic system.
Bronson Roderick T, Stins Monique F, Lin Tina, Zhuge Yuzheng, Perides George, Wu Julian K   +5 more
doaj   +1 more source

Towards an Analytical Procedure Control Strategy for the Capillary Zone Electrophoresis Method for Monoclonal Antibodies: Alternatives for ε‐Aminocaproic Acid and Triethylenetetramine

ELECTROPHORESIS, Volume 46, Issue 23, Page 1645-1650, December 2025.
ABSTRACT The ICH guideline Q14 on analytical procedure development underlines the importance of science and risk‐based methods for the evaluation of the quality of medicines. Ultimately, a pharmaceutical company, the sponsor, is responsible that the analytical method is fit‐for‐purpose during routine use throughout its lifecycle. Part of the analytical
Joanne Baxter, Lori Fitton, Cari E. Sänger ‐ van de Griend   +2 more
wiley   +1 more source

Effects of Tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats Efeitos do Tissucol® e do ácido épsilon aminocapróico no processo de reparo alveolar em ratos desidratados

Brazilian Oral Research, 2006
A histological study was conducted of the alveolar bone healing process following tooth extraction of dehydrated rats after the implantation of fibrin adhesive (TISSUCOL™) associated to previous irrigation of the wound with a 5% epsilon aminocaproic
Tetuo Okamoto, Maria Cristina Rosifini Alves-Rezende, Carolina Chiantelli Cláudio, Thaís da Silveira Rodrigues, Roberta Okamoto   +4 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations

Journal of Gastroenterology and Hepatology, Volume 40, Issue 12, Page 2842-2856, December 2025.
ABSTRACT Background Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under‐recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis.
Myo Jin Tang, Theng Yi Tay, Simon Gibbs, Ola Niewiadomski   +3 more
wiley   +1 more source

Nitrogen‐Centered Radical‐Directed C(sp3)−H Amination and Aminoalkylation Using (Diarylmethylene)amino Benziodoxolones

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
This report describes a C(sp3)−H aminofunctionalization via the photoexcitation of (diarylmethylene)amino benziodoxolones. These iodine reagents act as both single‐electron oxidants and nitrogen‐based SOMOphiles, serving as iminyl radicals, enabling the site‐selective C(sp3)−H amination and aminoalkylation of α‐aminoxy acid derivatives.
Kensuke Kiyokawa, Mari Sugimura, Megumi Abe, Daiki Wada, Hikaru Kaneba, Satoshi Minakata   +5 more
wiley   +1 more source

Cerebral sinus thrombosis as a potential hazard of antifibrinolytic treatment in menorrhagia.

, 1990
We describe a 42-year-old woman who developed superior sagittal and left transverse sinus thrombosis associated with prolonged epsilon-aminocaproic acid therapy for menorrhagia.
E Melamed, A Achiron, M Gornish
core   +1 more source