Results 61 to 70 of about 1,399 (158)

Enterococcus faecalis Translocation in Sepsis: Fibrinolysis and Mitochondrial Dysfunction Drive Lung Injury

Journal of Cellular and Molecular Medicine, Volume 29, Issue 21, November 2025.
ABSTRACT Sepsis frequently progresses to acute lung injury (ALI), characterised by inflammation, extracellular matrix degradation, and mitochondrial dysfunction. This study identifies Enterococcus faecalis as a gut‐derived bacterium that exploits the host fibrinolytic system for pulmonary translocation, resulting in mitochondrial damage and ...
Chenfei Wang, Dan Lv, Yuan Gao, Xinhui Xu, Changqing Zhu, Song Zhang, Keji Zhang   +6 more
wiley   +1 more source

Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis.

PLoS ONE, 2015
BackgroundRoutine use of antifibrinolytic agents in spine surgery is still an issue of debate.ObjectiveTo gather scientific evidence for the efficacy and safety of antifibrinolytic agents including aprotinin, tranexamic acid (TXA) and epsilon ...
Meng Wang, Xin-Feng Zheng, Lei-Sheng Jiang   +2 more
doaj   +1 more source

The Optimal Dose, Efficacy and Safety of Tranexamic Acid on Hemorrhage Control for High Tibial Osteotomy: A Network Meta‐Analysis

Orthopaedic Surgery, Volume 17, Issue 10, Page 2784-2808, October 2025.
Effect of TXA doses on outcomes for HTO patients. ABSTRACT Objective This systematic review and network meta‐analysis was performed to explore the optimal dose, efficacy, and safety of tranexamic acid (TXA) treatments versus placebo for high tibial osteotomy (HTO) patients.
Zhihu Zhao, Fei Xing, Wei Luo, Xin‐long Ma   +3 more
wiley   +1 more source

Interaction of a recombinant form of apolipoprotein[a] with human fibroblasts and with the human hepatoma cell line HepG2

Journal of Lipid Research, 1996
We have studied the binding, uptake, and degradation of a recombinant form of apolipoprotein[a] (r-apo[a]) using a cultured cell model. In HepG2 cells and in human fibroblasts, r-apo[a] complexed with low density lipoprotein(LDL) is bound and ...
S P Tam, X Zhang, M L Koschinsky
doaj   +1 more source

Retracted: Tranexamic Acid versus Epsilon-Aminocaproic Acid in Total Knee Arthroplasty: A Meta-Analysis. [PDF]

J Healthc Eng, 2023
Healthcare Engineering JO.
europepmc   +1 more source

Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials

BMC Cardiovascular Disorders, 2005
Background Aprotinin has been shown to be effective in reducing peri-operative blood loss and the need for re-operation due to continued bleeding in cardiac surgery.
Stokes Barrie J, Moxey Annette J, Carless Paul A, Henry David A   +3 more
doaj   +1 more source

Comparison of efficacy between tranexamic acid and epsilon-aminocaproic acid for total knee arthroplasty: A meta-analysis of randomized controlled trials. [PDF]

Medicine (Baltimore), 2023
Li J, Guo Y, Li M.
europepmc   +1 more source

Efficacy and safety of antifibrinolytic agents in spinal surgery: a network meta-analysis

Chinese Medical Journal, 2019
. Background:. Significant blood loss is still one of the most frequent complications in spinal surgery, which often necessitates blood transfusion. Massive perioperative blood loss and blood transfusion can create additional risks. Aprotinin, tranexamic
Lei Yuan, Yan Zeng, Zhong-Qiang Chen, Xin-Ling Zhang, Shuo Mai, Pan Song, Li-Yuan Tao, Qiang Shi   +7 more
doaj   +1 more source

Comparison of Efficacy and Safety of Two Commercial Artificial Tears Between 0.18% and 0.3% Sodium Hyaluronate for Corneal Epithelial Healing in Pterygium Excision with Conjunctival Autograft Transplantation: A Study Protocol for a Randomized Controlled Trial

Clinical Ophthalmology, 2022
Winai Chaidaroon, Suphitcha Pantarote, Phit Upaphong, Janejit Choovuthayakorn Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandCorrespondence: Winai Chaidaroon, Department of Ophthalmology, Faculty of Medicine,
Chaidaroon W, Pantarote S, Upaphong P, Choovuthayakorn J   +3 more
doaj  

Comparative Analysis of Topical Versus Intravenous Administration of Epsilon-Aminocaproic Acid on Blood Management in Total Knee Arthroplasty. [PDF]

Kans J Med, 2022
Lancaster BL, Wendling AC, Poppe TR, Zackula R, Massey WT, Cusick RP, Pappademos PC.   +6 more
europepmc   +1 more source