Results 201 to 210 of about 18,955 (239)
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Epsilon toxin: a fascinating pore‐forming toxin
The FEBS Journal, 2011Epsilon toxin (ETX) is produced by strains of Clostridium perfringens classified as type B or type D. ETX belongs to the heptameric β‐pore‐forming toxins including aerolysin and Clostridium septicum alpha toxin, which are characterized by the formation of a pore through the plasma membrane of eukaryotic cells consisting in a β‐barrel of 14 amphipatic β
Michel R Popoff
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Neurological disorders produced by Clostridium perfringens type D epsilon toxin
Anaerobe, 2004Although the epsilon toxin of Clostridium perfringens type D produces disease in many species of domestic livestock, neurological disturbance is more common and better studied in sheep. High levels of circulating toxin, especially in lambs, cause cerebral microvascular endothelial damage with disruption of the blood-brain barrier leading to a severe ...
John W Finnie
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CLOSTRIDIUM WELGHII EPSILON TOXIN IN THE INTESTINAL CONTENTS OF MAN
The Lancet, 1955M H, GLEESON-WHITE, J J, BULLEN
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Amino groups in Clostridium perfringens epsilon prototoxin and epsilon toxin
Microbial Pathogenesis, 1986Modification with succinic anhydride (SA) of Clostridium perfringens epsilon prototoxin or toxin resulted in a loss of activation by trypsin or lethal activity, respectively. The prototoxin was more sensitive to succinylation than the toxin. On the other hand, the succinylated prototoxin was activated and cleaved by chymotrypsin, but not by trypsin ...
J, Sakurai, M, Nagahama
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Carboxyl groups in Clostridium perfringens epsilon toxin
Microbial Pathogenesis, 1987The maximal number of norleucine methyl ester (NME) incorporated into carboxyl groups in epsilon toxin of Clostridium perfringens by the carbodiimide-nucleophile procedure was 7 and 17 in the absence and presence of 8 M urea, respectively. The introduction of 3-4 nucleophilic modifying agents such as NME, glycine methyl ester or taurine into carboxyl ...
J, Sakurai, M, Nagahama
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Clostridium perfringens epsilon-toxin requires acid sphingomyelinase for cellular entry
Anaerobe, 2023Clostridium perfringens epsilon-toxin is considered to be a crucial agent in enterotoxemia in domestic animals. Epsilon-toxin enters host cells via endocytosis and results in the formation of late endosome/lysosome-derived vacuoles. In the present study, we found that acid sphingomyelinase promotes the internalization of epsilon-toxin in MDCK cells.We ...
Yoshihiko, Sakaguchi +3 more
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Detection of Clostridium perfringens epsilon toxin by elisa
Research in Veterinary Science, 1987An enzyme-linked immunosorbent assay (ELISA) has been developed as an alternative to neutralisation tests in mice to detect Clostridium perfringens type D epsilon toxin in the intestinal contents of animals which have died from suspected enterotoxaemia. The test was sensitive and quantitative and gave excellent agreement with the mouse protection test.
R D, Naylor, P K, Martin, R T, Sharpe
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Cellular vacuolation induced by Clostridium perfringens epsilon‐toxin
The FEBS Journal, 2011The epsilon‐toxin of Clostridium perfringens forms a heptamer in the membranes of Madin–Darby canine kidney cells, leading to cell death. Here, we report that it caused the vacuolation of Madin–Darby canine kidney cells. The toxin induced vacuolation in a dose‐dependent and time‐dependent manner. The monomer of the toxin formed oligomers on lipid rafts
Masahiro, Nagahama +9 more
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Distribution of labeled Clostridium perfringens epsilon toxin in mice
Toxicon, 1991The in vivo distribution of labeled Clostridium perfringens epsilon toxin after i.v. administration to mice was investigated. High amounts of radioactivity were found in the kidneys and the brain, and small amounts were in the heart, lungs, liver and stomach.
M, Nagahama, J, Sakurai
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Clostridium perfringens Epsilon Toxin: Structural and Mechanistic Insights
2016Epsilon toxin (ETX) is produced by strains of Clostridium perfringens classified as type B or D. ETX belongs to the heptameric β-pore-forming toxins including Aeromonas aerolysin and Clostridium septicum alpha toxin, which are characterized by the formation of a pore through the plasma membrane of eukaryotic cells and containing a β-barrel composed of ...
Popoff, Michel R. +2 more
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