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Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng +9 more
wiley +1 more source
Toxin-Host Interaction of <i>Clostridium</i> Toxins. [PDF]
Toxins (Basel)Dorca-Arévalo J.
europepmc +1 more source
Congenital vascular malformations in the intestine of 2 neonatal goat kids. [PDF]
J Vet Diagn InvestRebollada-Merino A +3 more
europepmc +1 more source
Multiple sclerosis and clostridium perfringens epsilon toxin: is there a relationship?
Huss, André +5 more
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Clostridium perfringens epsilon toxin: The third most potent bacterial toxin known
Anaerobe, 2014Epsilon toxin (ETX) is produced by Clostridium perfringens type B and D strains and causes enterotoxemia, a highly lethal disease with major impacts on the farming of domestic ruminants, particularly sheep. ETX belongs to the aerolysin-like pore-forming toxin family.
Guilherme Guerra Alves +2 more
exaly +3 more sources
Amino groups in Clostridium perfringens epsilon prototoxin and epsilon toxin
Microbial Pathogenesis, 1986Modification with succinic anhydride (SA) of Clostridium perfringens epsilon prototoxin or toxin resulted in a loss of activation by trypsin or lethal activity, respectively. The prototoxin was more sensitive to succinylation than the toxin. On the other hand, the succinylated prototoxin was activated and cleaved by chymotrypsin, but not by trypsin ...
Jun Sakurai, Masahiro Nagahama
exaly +3 more sources
Direct Visualization of the Dynamic Process of Epsilon Toxin on Hemolysis
Small Methods, 2023AbstractHemolysis is the process of rupturing erythrocytes (red blood cells) by forming nanopores on their membranes using hemolysins, which then impede membrane permeability. However, the self‐assembly process before the state of transmembrane pores and underlying mechanisms of conformational change are not fully understood.
Bin Ji +10 more
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Carboxyl groups in Clostridium perfringens epsilon toxin
Microbial Pathogenesis, 1987The maximal number of norleucine methyl ester (NME) incorporated into carboxyl groups in epsilon toxin of Clostridium perfringens by the carbodiimide-nucleophile procedure was 7 and 17 in the absence and presence of 8 M urea, respectively. The introduction of 3-4 nucleophilic modifying agents such as NME, glycine methyl ester or taurine into carboxyl ...
J, Sakurai, M, Nagahama
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Detection of Clostridium perfringens epsilon toxin by elisa
Research in Veterinary Science, 1987An enzyme-linked immunosorbent assay (ELISA) has been developed as an alternative to neutralisation tests in mice to detect Clostridium perfringens type D epsilon toxin in the intestinal contents of animals which have died from suspected enterotoxaemia. The test was sensitive and quantitative and gave excellent agreement with the mouse protection test.
R D, Naylor, P K, Martin, R T, Sharpe
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Epsilon toxin: a fascinating pore‐forming toxin
The FEBS Journal, 2011Epsilon toxin (ETX) is produced by strains of Clostridium perfringens classified as type B or type D. ETX belongs to the heptameric β‐pore‐forming toxins including aerolysin and Clostridium septicum alpha toxin, which are characterized by the formation of a pore through the plasma membrane of eukaryotic cells consisting in a β‐barrel of 14 amphipatic β
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