Results 61 to 70 of about 1,328,799 (258)

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk, Afshin Shameli, Erik Ames, Jonathan R. Fromm, Bartosz Grzywacz, Min Shi, Sindhu Cherian, Jean Oak   +7 more
wiley   +1 more source

Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication. [PDF]

, 2007
EBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 ...
Xue, SA, Griffin, BE
core  

Expression of the anti-apoptotic bfl-1/A1 gene is regulated by the Epstein Barr virus nuclear antigen 2(EBNA2) [PDF]

, 2003
The ubiquitous and oncogenic human herpesvirus Epstein-Barr virus (EBV) establishes a latent infection and promotes the long-term survival of the infected host cell by targeting the molecular machinery that controls cell fate decisions (apoptosis ...
Pegman, Pamela Mary
core   +2 more sources

Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir

mBio
Epstein-Barr virus (EBV) is a ubiquitous human tumor virus that establishes lifelong, persistent infections in B cells. The presence of EBV in cancer cells presents an opportunity to target these cells by reactivating the virus from latency.
Febri Gunawan Sugiokto, Renfeng Li
doaj   +1 more source

Subset‐specific and tissue‐specific expression of NK‐cell markers and killer immunoglobulin‐like receptors: Implications for NK‐cell clonality assessment

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate immunophenotypic evaluation of natural killer (NK)‐cell neoplasms is challenging because NK‐cells lack somatically rearranged antigen receptors, are comprised of phenotypically distinct subsets, and exhibit tissue‐specific subset distribution. We developed a flow cytometry (FC) panel for NK‐cell immunophenotypic analysis and clonality
Valerie Woodings, Orrin Koepke, Jason E. Love, Alireza Torabi, Lianqun Qiu, Jonathan R. Fromm, Sindhu Cherian, Afshin Shameli   +7 more
wiley   +1 more source

Contribution of Epstein-Barr Virus Infection to Chemoresistance of Gastric Carcinoma Cells to 5-Fluorouracil

, 2012
Although Epstein-Barr virus EBV is associated with 6-16% of the gastric carcinoma GC cases, the effect of EBV infection on the tumorigenesis process and the responsiveness to chemotherapy remain unclear.
陳振陽, Seo, Jung; Kim, Tai-Gyu; Hong, Young Seon; Chen, Jen-Yang; Lee, Suk Kyeong   +1 more
core   +1 more source

mSphere of Influence: 3-D Culture Models Influence Studies on Epstein-Barr Virus Molecular Pathogenesis in the Epithelium

mSphere, 2020
Kathy Shair works in the field of Epstein-Barr virus (EBV)-associated cancers, with emphasis on nasopharyngeal carcinoma (NPC). In this mSphere of Influence article, she reflects on how the paper “Efficient replication of Epstein-Barr virus in stratified
K. H. Y. Shair
doaj   +1 more source

Comparison of EBER flow FISH results from two facilities

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Epstein–Barr virus (EBV) primarily infects B cells but can occasionally target T and/or NK cells, leading to chronic active EBV disease or EBV‐associated hemophagocytic lymphohistiocytosis, which are often difficult to treat. EBV‐associated diseases exhibit a wide range of phenotypes.
Madoka Nishimura, Dan Tomomasa, Eri Watanabe, Kazumi Tsuchiya, Natsuko Sato, Takayuki Takachi, Kohsuke Imai, Hiroki Akiyama, Masahiro Ueki, Kota Yoshifuji, Hiroshi Yasui, Kay Tanita, Akihiro Hoshino, Hirokazu Kanegane   +13 more
wiley   +1 more source

Characterization of murine gammaherpesvirus 68 glycoprotein B (gB) homolog: similarity to Epstein-Barr virus gB (gp110) [PDF]

, 1994
Murine gammaherpesvirus 68 (MHV-68) is a natural pathogen of murid rodents and displays similar pathobiological characteristics to those of the human gammaherpesvirus Epstein-Barr virus (EBV).
Sunil-Chandra, N P, Nash, Anthony, Janjua, N J, Arrand, J R, Stewart, J.P.   +4 more
core  

Оptimization of Treatment EBV Infectious Mononucleosis in Children

Детские инфекции (Москва), 2015
The paper presents the results of observation of 103 children aged from 10 months to 15 years with EBV-associated infectious mononucleosis (IM), determined in 32% by acute primary Epstein-Barr virus infection (AEBVI) and in 68% of cases by reactivation ...
V. B. Kotlova, S. P. Kokoreva, A. V. Trushkina   +2 more
doaj   +1 more source