Results 131 to 140 of about 40,172 (233)

Multi‐View Biomedical Foundation Models for Molecule‐Target and Property Prediction

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Molecular foundation models can provide accurate predictions for a large set of downstream tasks. We develop MMELON, an approach that integrates pre‐trained graph, image, and text foundation models and validate our multi‐view model on over 120 tasks, including GPCR binding.
Parthasarathy Suryanarayanan, Yunguang Qiu, Shreyans Sethi, Diwakar Mahajan, Hongyang Li, Yuxin Yang, Elif Eyigoz, Aldo Guzmán‐Sáenz, Daniel E. Platt, Timothy H. Rumbell, Kenney Ng, Sanjoy Dey, Myson Burch, Bum Chul Kwon, Pablo Meyer, Feixiong Cheng, Jianying Hu, Joseph A. Morrone   +17 more
wiley   +1 more source

eQTL-Detect: nextflow-based pipeline for eQTL detection in modular format with sharable and parallelizable scripts

NAR Genomics and Bioinformatics
Abstract Bioinformatic pipelines are becoming increasingly complex with the ever-accumulating amount of Next-generation sequencing (NGS) data. Their orchestration is difficult with a simple Bash script, but bioinformatics workflow managers such as Nextflow provide a framework to overcome respective problems.
Chitneedi, Praveen Krishna, Hadlich, Frieder, Moreira, Gabriel C. M., Espinosa-Carrasco, Jose, Li, Changxi, Plastow, Graham, Fischer, Daniel, Charlier, Carole, Rocha, Dominique, Chamberlain, Amanda J., Kuehn, Christa   +10 more
openaire   +4 more sources

PICALO: principal interaction component analysis for the identification of discrete technical, cell-type, and environmental factors that mediate eQTLs

Genome Biology
Expression quantitative trait loci (eQTL) offer insights into the regulatory mechanisms of trait-associated variants, but their effects often rely on contexts that are unknown or unmeasured.
Martijn Vochteloo, Patrick Deelen, Britt Vink, BIOS Consortium, Ellen A. Tsai, Heiko Runz, Sergio Andreu-Sánchez, Jingyuan Fu, Alexandra Zhernakova, Harm-Jan Westra, Lude Franke   +10 more
doaj   +1 more source

An atlas of single-cell eQTLs dissects autoimmune disease genes and identifies novel drug classes for treatment

Cell Genomics
Summary: Most variants identified from genome-wide association studies (GWASs) are non-coding and regulate gene expression. However, many risk loci fail to colocalize with expression quantitative trait loci (eQTLs), potentially due to limited GWAS and ...
Lida Wang, Havell Markus, Dieyi Chen, Siyuan Chen, Fan Zhang, Shuang Gao, Chachrit Khunsriraksakul, Fang Chen, Nancy Olsen, Galen Foulke, Bibo Jiang, Laura Carrel, Dajiang J. Liu   +12 more
doaj   +1 more source

eQTL Detector; an automated pipeline for eQTL mapping and downstream analysis

, 2020
L'accés a tecnologies de genotipat tant d'ADN com ARN han obert una nou paradigma en el mapatge de caràcters complexos, aquestes estan basades en l'avaluació de la interacció del genotip i altres variables com a metilacions, proteïnes o nivells d'expressió genètica, en relació a aquesta última variable, els denominats QTL d'expressió (eQTL) tracten de ...
openaire   +1 more source

Fast Genome-Wide QTL Analysis Using Mendel

, 2014
Pedigree GWAS (Option 29) in the current version of the Mendel software is an optimized subroutine for performing large scale genome-wide QTL analysis.
Hu, Tao, Lange, Kenneth, Sobel, Eric M, Zhou, Hua, Zhou, Jin   +4 more
core  

Disease heritability explained by eQTLs [PDF]

Nature Methods, 2020
openaire   +2 more sources

Identification of blood eQTLs in older adults

Gene
Genome-wide association studies (GWAS) have been successful in identifying genetic variation associated with a wide range of phenotypes. However, more detailed knowledge of their functional significance is required to provide insights into the molecular mechanisms involved.
Abdulsalam, Toyin, Karen A, Mather, Nicola J, Armstrong, Liliana G, Ciobanu, Bernhard T, Baune, John B, Kwok, Peter R, Schofield, David, Ames, Julian N, Trollor, Perminder S, Sachdev, Anbupalam, Thalamuthu   +10 more
openaire   +2 more sources

Scalable eQTL mapping using single-nucleus RNA-sequencing of recombined gametes from a small number of individuals.

PLoS Biology
Phenotypic differences between individuals of a species are often caused by differences in gene expression, which are in turn caused by genetic variation.
Matthew T Parker, Samija Amar, José A Campoy, Kristin Krause, Sergio Tusso, Magdalena Marek, Bruno Huettel, Korbinian Schneeberger   +7 more
doaj   +1 more source

Multi-Omics and Single-Cell Mendelian Randomization Reveal a Potential Role of <i>VNN2</i> in Lung Adenocarcinoma in Resting Natural Killer Cells. [PDF]

World J Oncol
Xue ZC, Lin J, Wu JH, Peng ZW, Tang MY, Liang P, Chen HL, Fang GJ, Xue Q.   +8 more
europepmc   +1 more source