Results 131 to 140 of about 46,677 (295)
Plant, Cell &Environment, EarlyView.ABSTRACT Brassica napus (canola) is a significant contributor to the world's oil production and is cultivated across continents, yet acidic soils with aluminium (Al3+) and manganese (Mn2+) toxicities limit its production. The genetic determinants underlying natural variation for acidic soil tolerance in canola are unknown and need to be determined ...
Harsh Raman +13 more
wiley +1 more source
Deconvolution of bulk blood eQTL effects into immune cell subpopulations
BMC Bioinformatics, 2019 Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, which are likely to
Raúl Aguirre-Gamboa +23 more
semanticscholar +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 8, Page 168-189, December 2025.ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino +8 more
wiley +1 more source
Optimal design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis
bioRxiv, 2019 Single-cell RNA-sequencing (scRNA-Seq) is a compelling approach to simultaneously measure cellular composition and state which is impossible with bulk profiling approaches.
Igor Mandric +7 more
semanticscholar +1 more source
Cancer Innovation, Volume 4, Issue 6, December 2025.Schematic of the methodology applied in this study. Step 1: Gene co‐expression was used to build networks and for enrichment analysis in CRC and villi. Step 2: Identify disordered genes and continuously upregulated/downregulated “off‐track genes” in CRC.
Botao Zhang +6 more
wiley +1 more source
Estimation of Interpretable eQTL Effect Sizes Using a Log of Linear\n Model [PDF]
, 2016 John Palowitch +4 more
openalex +1 more source
Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1463-1476, December 2025.Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu +21 more
wiley +1 more source
Multi‐Omics‐Augmented GWAS for Crop Improvement: From Mechanisms to Breeding
Modern Agriculture, Volume 3, Issue 2, December 2025.This review presents an integrated framework that synergises multi‐omics with GWAS and machine learning to decode the genetic basis of complex agronomic traits, bridging biological discovery to precision breeding for climate‐resilient crops. ABSTRACT Global food security demands innovative strategies to enhance crop resilience and productivity amidst ...
Naimatullah Mangi +17 more
wiley +1 more source
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
PLoS Genetics, 2008 Genome-wide gene expression profiling has been extensively used to generate biological hypotheses based on differential expression. Recently, many studies have used microarrays to measure gene expression levels across genetic mapping populations.
Chunlei Wu +19 more
doaj +1 more source