Results 121 to 130 of about 15,432 (253)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Equations of Motion and Navier–Stokes Equations

open access: yesComputation
In this research, we present the analogies between variational calculations in cosmology and in classical mechanics. Our approach is based on the invariants for transformations of affine connections defined on N-dimensional manifolds (special cases are the 8-dimensional, 5-dimensional, and 4-dimensional manifolds used in cosmology and 2-dimensional ...
Dusan J. Simjanovic   +4 more
openaire   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Examining the impact of violations of local item independence assumption on test equating methods

open access: yesInternational Journal of Assessment Tools in Education
This study investigates the impact of violating the local item independence assumption by loading certain items onto a second dimension on test equating errors in unidimensional and dichotomous tests.
Şeref Tan, Mehmet Fatih Doğuyurt
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Equipercentile equating via data-imputation techniques

open access: yes
extended beta-binomial model, common-item equating, EM algorithm, equipercentile equating, log-linear smoothing, moment estimator,
Philip Cheng, Michelle Liou
core   +1 more source

Impact of differential item functioning on item model fit using concurrent equating method

open access: yesLarge-scale Assessments in Education
This study aimed to evaluate the item model fit by equating the forms of the PISA 2018 mathematics subtest with concurrent common items equating in samples from Türkiye, the UK, and Italy.
Zeynep Uzun, Tuncay Öğretmen
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

A numerical approach for computing standard errors of linear equating

open access: yes, 1993
A numerical approach for computing standard errors (SEs) of a linear equating is described. In the proposed approach, the first partial derivatives of the equating function needed to compute the SEs are derived numerically.
Zeng, Lingjia
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

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