Results 111 to 120 of about 45,141 (310)

An Equational Metalogic for Monadic Equational Systems

Theory and Applications of Categories, 2013
The paper presents algebraic and logical developments. From the algebraic viewpoint, we introduce Monadic Equational Systems as an abstract enriched notion of equational presentation. From the logical viewpoint, we provide Equational Metalogic as a general formal deductive system for the derivability of equational consequences.
openaire   +3 more sources

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Contributions to Kernel Equating

, 2014
The statistical practice of equating is needed when scores on different versions of the same standardized test are to be compared. This thesis constitutes four contributions to the observed-score equating framework kernel equating. Paper I introduces the
Andersson, Björn
core  

Harmonizing the CBCL and SDQ ADHD scores by using linear equating, kernel equating, item response theory and machine learning methods

Frontiers in Psychology
IntroductionA problem that applied researchers and practitioners often face is the fact that different institutions within research consortia use different scales to evaluate the same construct which makes comparison of the results and pooling ...
Miljan Jović, Maryam Amir Haeri, Andrew Whitehouse, Stéphanie M. van den Berg   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

IRT Observed-score Kernel Equating

, 2014
Item response theory (IRT) observed-score kernel equating is described for thenon-equivalent groups with anchor test equating design using either chain equating orpost-stratification equating.
Andersson, Björn, Wiberg, Marie
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

plink: An R Package for Linking Mixed-Format Tests Using IRT-Based Methods

The R package plink has been developed to facilitate the linking of mixed-format tests for multiple groups under a common item design using unidimensional and multidimensional IRT-based methods.
Jonathan P. Weeks
core  

Equations of Motion and Navier–Stokes Equations

Computation
In this research, we present the analogies between variational calculations in cosmology and in classical mechanics. Our approach is based on the invariants for transformations of affine connections defined on N-dimensional manifolds (special cases are the 8-dimensional, 5-dimensional, and 4-dimensional manifolds used in cosmology and 2-dimensional ...
Dusan J. Simjanovic, Ivana Djurisic, Aleksandra Penjisevic, Marko Stefanovic, Branislav M. Randjelovic   +4 more
openaire   +1 more source