Results 91 to 100 of about 45,141 (310)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
A Bayesian Nonparametric Approach to Test Equating
, 2009 Bayesian nonparametrics, bivariate Bernstein polynomial prior, Dirichlet process prior, test equating, equipercentile equating, linear equating,
Stephen Walker +3 more
core +1 more source
Some conceptual issues in observed-score equating [PDF]
, 2013 In spite of all of the technical progress in observed-score equating, several of the more conceptual aspects of the process still are not well understood.
van der Linden, Willem J.
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The Asymptotic Equating Methodology and Other Test Equating Evaluation Procedures
, 1993 A methodology is proposed to evaluate the asymptotic performance of test equating methods and of various test equating indices. A test theoretic viewpoint is taken to develop the asymptotic equating methodology and the conditional equating analyses ...
Thomasson, Gary Lee
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Test equating sleep scales: applying the Leunbach’s model
BMC Medical Research Methodology, 2019 Background In most cases, the total scores from different instruments assessing the same construct are not directly comparable, but must be equated. In this study we aimed to illustrate a novel test equating methodology applied to sleep functions, a ...
Núria Duran Adroher +4 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Equating tests under the graded response model
, 1992 The Stocking and Lord (1983) procedure for computing equating coefficients for tests having dichotomously scored items is extended to the case of graded response items.
Baker, Frank B.
core +1 more source