Results 21 to 30 of about 219,775 (187)

Human Adenovirus 36 Antibodies in Horses with Different Metabolic Statuses [PDF]

Animals
This study investigated the presence of antibodies to human adenovirus type 36 (HAdV-D36) in horses with different metabolic statuses, including normal, overweight, and those diagnosed with equine metabolic syndrome (EMS).
Aleksandra Chwirot, Artur Niedźwiedź, Dominika Stygar, Natalia Siwińska, Marzena Paszkowska, Wojciech Niżański, Skarlet Napierkowska, Paweł Migdał, Agata Kublicka, Maja Marynowska, Anna Matczuk, Devon Fuller, Barbara Bażanów   +12 more
doaj   +2 more sources

Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses. [PDF]

Cell Commun Signal, 2023
Background Equine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds ...
Bourebaba N, Sikora M, Qasem B, Bourebaba L, Marycz K.   +4 more
europepmc   +2 more sources

In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment. [PDF]

Stem Cell Rev Rep, 2023
Equine metabolic syndrome (EMS) is recognized as one of the leading cause of health threatening in veterinary medicine worldwide. Recently, PTP1B inhibition has been proposed as an interesting strategy for liver insulin resistance reversion in both ...
Marycz K, Bourebaba N, Serwotka-Suszczak A, Mularczyk M, Galuppo L, Bourebaba L.   +5 more
europepmc   +2 more sources

The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses. [PDF]

Front Endocrinol (Lausanne), 2023
Background Equine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis.
Bourebaba L, Serwotka-Suszczak A, Pielok A, Sikora M, Mularczyk M, Marycz K.   +5 more
europepmc   +2 more sources

A practical approach to hyperinsulinaemia in horses with equine metabolic syndrome

Equine Veterinary Education
Summary Laminitis associated with hyperinsulinaemia is a significant cause of morbidity and mortality in horses with equine metabolic syndrome. The diagnosis and management of hyperinsulinaemia are therefore critical to prevent the development of laminitis.
Tania Sundra, Gabriele Rossi, David Rendle, Guy Lester   +3 more
openaire   +2 more sources

Equine metabolic syndrome in UK native ponies and cobs is highly prevalent with modifiable risk factors. [PDF]

Equine Vet J, 2021
Background The epidemiology of equine metabolic syndrome (EMS) is poorly described. Objectives To estimate the prevalence of EMS in native UK ponies and cobs in England and Wales and identify associated risk factors.
Carslake HB, Pinchbeck GL, McGowan CM.
europepmc   +2 more sources

Methodologies to Identify Metabolic Pathway Differences Between Emaciated and Moderately Conditioned Horses: A Review of Multiple Gene Expression Techniques [PDF]

Animals
Starvation in horses presents critical welfare, economic, and management challenges with underlying molecular mechanisms of metabolic modification and recovery left poorly defined.
Madeline M. P. Austin, Jennie L. Z. Ivey, Elizabeth A. Shepherd, Phillip R. Myer   +3 more
doaj   +2 more sources

Sodium-glucose transporters SGLT1 and SGLT2 in equine renal, hepatic and pancreatic tissue [PDF]

BMC Veterinary Research
Background Insulin dysregulation is a hallmark of equine metabolic syndrome (EMS), and in recent years, pharmacological treatment with sodium-dependent glucose transporter 2 inhibitors (SGLT2i) have shown promise in reducing the risk of hyperinsulinemia ...
Camilla Anger-Håål, Cathrine T. Fjordbakk, Carl Ekstrand, Fredrik S. Skedsmo, Runa Rørtveit   +4 more
doaj   +2 more sources

Heritability of metabolic traits associated with equine metabolic syndrome in Welsh ponies and Morgan horses

Equine Veterinary Journal, 2018
Summary Background Equine metabolic syndrome ( EMS ) is a complex clinical disorder with both environmental and genetic factors contributing to EMS phenotypes.
E. M. Norton, N. E. Schultz, A. K. Rendahl, D. Mcfarlane, R. J. Geor, J. R. Mickelson, M. E. McCue   +6 more
openaire   +4 more sources

Metabogenomics reveals four candidate regions involved in the pathophysiology of Equine Metabolic Syndrome. [PDF]

Mol Cell Probes, 2020
An analogous condition to human metabolic syndrome, Equine Metabolic Syndrome (EMS) is defined by several clinical signs including obesity, hyperinsulinemia, and peripheral insulin dysregulation (ID).
Patterson Rosa L, Mallicote MF, Long MT, Brooks SA.   +3 more
europepmc   +2 more sources