Results 71 to 80 of about 2,214,130 (267)

Exploring Consistency in the Three-Option Davidson Model: Bridging Pairwise Comparison Matrices and Stochastic Methods

open access: yesMathematics
In this paper, data consistency in the three-option Davidson model is investigated. Starting out with the usual consistency definition in pairwise matrices-based methods, we examine its consequences.
Anna Tóth-Merényi   +3 more
doaj   +1 more source

A Hilbert-type integral inequality in the whole plane related to the kernel of exponent function

open access: yesJournal of Inequalities and Applications, 2018
By using real analysis and weight functions, we obtain a few equivalent statements of a Hilbert-type integral inequality in the whole plane related to the kernel of exponent function with intermediate variables.
Yanru Zhong, Meifa Huang, Bicheng Yang
doaj   +1 more source

Partition Problems and a Pattern of Vertical Sums [PDF]

open access: yes, 2017
We give a possible explanation for the mystery of a missing number in the statement of a problem that asks for the non-negative integers to be partitioned into three subsets.
Krinsky, Eunice   +2 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

A non-trivial connection for the metric-affine Gauss–Bonnet theory in D = 4

open access: yesPhysics Letters B, 2019
We study non-trivial (i.e. non-Levi-Civita) connections in metric-affine Lovelock theories. First we study the projective invariance of general Lovelock actions and show that all connections constructed by acting with a projective transformation of the ...
Bert Janssen   +2 more
doaj   +1 more source

Homotopy equivalences between p-subgroup categories [PDF]

open access: yes, 2014
Let p be a prime number and G a finite group of order divisible by p. Quillen showed that the Brown poset of nonidentity p-subgroups of G is homotopy equivalent to its subposet of nonidentity elementary abelian subgroups.
Jesper, M. Møller, Matthew Gelvin
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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