Results 61 to 70 of about 2,101,126 (257)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Statement of Purpose

, 2013
Toledo N.O.W.
National Organization for Women - Toledo Chapter
core  

English-Ukrainian translation of synesthetic metaphors: Evidence from keystroke logging and corpus analysis

East European Journal of Psycholinguistics
Linguistic synesthesia is treated as a kind of metaphor occurring in languages commonly and naturally, like any conceptual metaphor. It is a product of mapping between two different domains of human experience, a transfer from one sensory domain (the ...
Olha Zhulavska, Alla Martynyuk
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Equivalent Permeability of Step-Lap Joints of Transformer Cores: Computational and Experimental Considerations [PDF]

, 2011
The paper develops an efficient computational method for establishing equivalent characteristics of magnetic joints of transformer cores, with special emphasis on step-lap design.
Napieralska-Juszczak, E., Napieralska-Juszczak, Ewa, Komeza, Krzysztof, Ewa Napieralska-Juszczak, Sykulski, J.K., Jan K. Sykulski, Sykulski, Jan, Hihat, N., Hihat, Nabil, Lecointe, Jean-Philippe, Jean-Philippe Lecointe, Lecointe, J-P., Nabil Hihat, Komeza, K., Krzysztof Komeza   +14 more
core   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A non-trivial connection for the metric-affine Gauss–Bonnet theory in D = 4

Physics Letters B, 2019
We study non-trivial (i.e. non-Levi-Civita) connections in metric-affine Lovelock theories. First we study the projective invariance of general Lovelock actions and show that all connections constructed by acting with a projective transformation of the ...
Bert Janssen, Alejandro Jiménez-Cano, José Alberto Orejuela   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Statement of Partnership Principles [PDF]

, 2013
In September 2009 Oxfam’s need for an OI Partnership Policy was confirmed. An internal consultation determined the document should take the form of a Statement of Partnership Principles.
GB, Oxfam
core   +1 more source

Statement of cash flows

, 2012
The statement of cash flows is useful for users of financial statements, as it provides information to help assess an entity's ability to generate cash flows, meet its obligations and appreciate why assets and liabilities have changed.
Chalmers, Keryn, Birt, Jacqueline, Byrne, Suzanne, Oliver, Judy, Brooks, Albie   +4 more
core   +1 more source