Results 81 to 90 of about 4,452,390 (325)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
MathematicsIn this paper, data consistency in the three-option Davidson model is investigated. Starting out with the usual consistency definition in pairwise matrices-based methods, we examine its consequences.
Anna Tóth-Merényi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Position statement and guidelines on unmodified electroconvulsive therapy
Indian Journal of Psychiatry, 2012 Background: In modern day psychiatric practice, it is assumed as a matter of fact that when electroconvulsive therapy (ECT) is administered, it will be administered under anesthesia and with succinylcholine (or its equivalent) modification.
C. Andrade +9 more
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A theoretical analysis of the risk evaluation formulas for spectrum-based fault localization
TSEM, 2013 An important research area of Spectrum-Based Fault Localization (SBFL) is the effectiveness of risk evaluation formulas. Most previous studies have adopted an empirical approach, which can hardly be considered as sufficiently comprehensive because of the
Xiaoyuan Xie +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
A non-trivial connection for the metric-affine Gauss–Bonnet theory in D = 4
Physics Letters B, 2019 We study non-trivial (i.e. non-Levi-Civita) connections in metric-affine Lovelock theories. First we study the projective invariance of general Lovelock actions and show that all connections constructed by acting with a projective transformation of the ...
Bert Janssen +2 more
doaj +1 more source
On the Gibbs-Liouville theorem in classical mechanics
, 2019 In this article, it is argued that the Gibbs-Liouville theorem is a mathematical representation of the statement that closed classical systems evolve deterministically.
Henriksson, Andreas
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