4‐Hydroxytamoxifen induces a noncanonical ferroptosis in lung adenocarcinoma by targeting AKR1B10
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.4‑OHT directly inhibits AKR1B10 enzymatic activity to induce noncanonical ferroptosis in LUAD. AKR1B10 sustains LUAD survival by stabilising ACC1 and detoxifying reactive carbonyl species (RCSs). Nanatinostat similarly targets AKR1B10 and elicits the same cell death modality.
Hui Yang +8 more
wiley +1 more source
Estrogen receptor β deficiency increases susceptibility to sepsis through metabolic reprogramming-induced macrophage pyroptosis. [PDF]
J Clin InvestZhu Y +12 more
europepmc +1 more source
The role of holistic student mentorship in academia
Ecosphere, Volume 17, Issue 9, September 2026.Abstract Recruitment and retention of diverse students and future faculty in science, technology, engineering, and mathematics (STEM) is essential for ensuring the STEM fields, like ecology, become more inclusive and relevant to people that represent the diversity of our global society.
Gabriela Palomo‐Munoz +2 more
wiley +1 more source
Intratumoral but not circulating estradiol predicts postoperative survival in men with hepatocellular carcinoma. [PDF]
Discov OncolWang Y +10 more
europepmc +1 more source
Applied Numerical Modelling of Landscape Evolution in Anthropogenic Landscapes: A Systematic Review
Earth Surface Processes and Landforms, Volume 51, Issue 9, September 2026.This systematic review examines how landscape evolution models have been applied to analyse long‐term change in anthropogenic landscapes. The review evaluates modelling approaches, applications, limitations and key knowledge gaps to assess the potential of these models for long‐term landscape and risk management.
Vinuri Piyathilake +2 more
wiley +1 more source
Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways. [PDF]
Curr Issues Mol BiolOlteanu IL +3 more
europepmc +1 more source
Sodium Intake and Osteoporosis Risk: Evidence From NHANES and Mendelian Randomization Analysis
Food Science &Nutrition, Volume 14, Issue 9, September 2026.This study combined cross‐sectional data from the National Health and Nutrition Examination Survey (NHANES) with Mendelian Randomization (MR) analysis to systematically investigate the relationship between sodium intake and osteoporosis. The results showed that within a specific intake range (> 6150 mg/day), sodium intake was significantly negatively ...
Yunxiao Ji +5 more
wiley +1 more source
The double-edged sword effect of estrogen in kidney disease and its precision modulation. [PDF]
Front Endocrinol (Lausanne)Zhang J +7 more
europepmc +1 more source
Global Change Biology Communications, Volume 1, Issue 3, September 2026.We show that impacts of agriculture on arthropod biodiversity are notably less negative in Europe than in other regions, which we find is driven by a degraded baseline, a selection bias of reference sites, and novel species compositions in agriculture that favour widespread habitat generalists and non‐native species.
Daan Scheepens +3 more
wiley +1 more source
Thymoquinone Enhances Tamoxifen Efficacy Against Triple-Negative Breast Cancer by Targeting EMT Signaling. [PDF]
Int J Breast CancerHaque M +4 more
europepmc +1 more source