Results 161 to 170 of about 2,874 (176)
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ERAP1-ERAP2 haplotypes are associated with ankylosing spondylitis in Polish patients
Human Immunology, 2019The objective of this case-control study was to evaluate the role of four single-nucleotide polymorphisms in the ERAP1 (rs2287987, rs30187, rs27044) and ERAP2 (rs2248374) genes and their haplotypes in predicting the risk for ankylosing spondylitis (AS) on a well-defined Polish population.
Andrzej, Wiśniewski +7 more
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EpCAM associates with endoplasmic reticulum aminopeptidase 2 (ERAP2) in breast cancer cells
Biochemical and Biophysical Research Communications, 2013Epithelial cell adhesion molecule (EpCAM) is an epithelial and cancer cell "marker" and there is a cumulative and growing evidence of its signaling role. Its importance has been recognized as part of the breast cancer stem cell phenotype, the tumorigenic breast cancer stem cell is EpCAM(+).
Salah-Eldin, Gadalla +6 more
openaire +2 more sources
Nature Immunology, 2005
The generation of many HLA class I peptides entails a final trimming step in the endoplasmic reticulum that, in humans, is accomplished by two 'candidate' aminopeptidases. We show here that one of these, ERAP1, was unable to remove several N-terminal amino acids that were trimmed efficiently by the second enzyme, ERAP2.
Loredana Saveanu +2 more
exaly +4 more sources
The generation of many HLA class I peptides entails a final trimming step in the endoplasmic reticulum that, in humans, is accomplished by two 'candidate' aminopeptidases. We show here that one of these, ERAP1, was unable to remove several N-terminal amino acids that were trimmed efficiently by the second enzyme, ERAP2.
Loredana Saveanu +2 more
exaly +4 more sources
Journal of Cellular Physiology, 2008
AbstractThe endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 contribute to generate HLA class I binding peptides. Recently, we have shown that the expression of these enzymes is high and coordinated (with each other and with HLA class I molecules) in immortalized B cells, but variable and imbalanced in human tumour cell lines of various non ...
Fruci D +7 more
openaire +4 more sources
AbstractThe endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 contribute to generate HLA class I binding peptides. Recently, we have shown that the expression of these enzymes is high and coordinated (with each other and with HLA class I molecules) in immortalized B cells, but variable and imbalanced in human tumour cell lines of various non ...
Fruci D +7 more
openaire +4 more sources
Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations
Human Immunology, 2019The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I-mediated antigen presentation and educating the immune system to differentiate between self-derived and foreign antigens.
Yufeng Yao +3 more
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Intracellular antigen processing by ERAP2: Molecular mechanism and roles in health and disease
Human Immunology, 2019Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) is an intracellular enzyme localized in the ER that has been shown to play roles in the generation of peptides that serve as ligands for MHC class I (MHC-1) molecules. Although ERAP2 has been primarily described as an accessory and complementary enzyme to the homologous ERAP1, several lines of evidence ...
José A López, de Castro +1 more
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M9.2 Dissecting the allelic architecture of ERAP2: a novel preeclampsia susceptibility gene
Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, 2010Matthew Johnson1, John Blangero1, Christine East2, Rigmor Austgulen3, Shaun Brennecke2, Eric Moses1. 1Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX, USA; 2Department of Perinatal Medicine, Royal Women’s Hospital & Department of Obstetrics & Gynaecology, University of Melbourne, Melbourne, Australia; 3Department ...
Matthew Johnson +5 more
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Function of ERAP2 (endoplasmic reticulum aminopeptidase 2) in cancer immunity
Journal of Reproductive Immunology, 2021Nobuki Hayashi +10 more
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Abstract B080: ERAP2 overexpression and anti-PD-1 resistance in nasopharyngeal carcinoma
Cancer Immunology ResearchAbstract Anti-PD1 therapy in nasopharyngeal carcinoma (NPC) demonstrates limited efficacy, with only 19.3% of patients achieving one-year progression-free survival. Identifying predictive biomarkers is crucial for enhancing therapeutic outcomes.
Luvita Suryani +13 more
openaire +1 more source