Results 151 to 160 of about 2,874 (176)

Single Cell Transcriptomics Genomics Based on Machine Learning Algorithm: Constructing and Validating Neutrophil Extracellular Trap Gene Model in COPD. [PDF]

Int J Gen Med
Yu J, Xiao T, Pan Y, He Y, Tan J.
europepmc   +1 more source

Exploring the Pathogenesis of Spondylarthritis beyond HLA-B27: A Descriptive Review. [PDF]

Int J Mol Sci
Nagit RE, Rezus E, Cianga P.
europepmc   +1 more source

Identification of immune- and oxidative stress-related signature genes as potential targets for mRNA vaccines for pancreatic cancer patients. [PDF]

Medicine (Baltimore)
Li J, Han Y, Zhao N, Lv L, Ma P, Zhang Y, Li M, Sun H, Deng J, Zhang Y.   +9 more
europepmc   +1 more source

Viral manipulation of the HLA class I antigen processing and presentation pathway. [PDF]

Front Immunol
Nolan DS, Altenburg AF.
europepmc   +1 more source

Integrating plasma proteomics with genome-wide association data to identify novel drug targets for inflammatory bowel disease. [PDF]

Sci Rep
Bai Z, Hao J, Chen M, Yao K, Zheng L, Liu L, Hu J, Guo K, Lv Y, Li F.   +9 more
europepmc   +1 more source

Host control of latent Epstein-Barr virus infection

Schmidt A, Alawathurage TM, Frach L, Richter S, David FS, Schaefer M, Henne SK, Boztug K, Proebstel A, Noethen MM, Beins EC, Ludwig KU.   +11 more
europepmc   +1 more source

Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target‐Guided Synthesis

Angewandte Chemie - International Edition, 2022
AbstractEndoplasmic reticulum aminopeptidase 2 (ERAP2) is a key enzyme involved in the trimming of antigenic peptides presented by Major Histocompatibility Complex class I. It is a target of growing interest for the treatment of autoimmune diseases and in cancer immunotherapy.
Virgyl Camberlein, Sierocki Pierre, Lenong Li   +2 more
exaly   +4 more sources

ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19? [PDF]

International Journal of Molecular Sciences, 2021
Patients with coronavirus disease 2019 (COVID-19) have a wide variety of clinical outcomes ranging from asymptomatic to severe respiratory syndrome that can progress to life-threatening lung lesions. The identification of prognostic factors can help to improve the risk stratification of patients by promptly defining for each the most effective therapy ...
Silvia D'Amico, Patrizia Tempora, Ombretta Melaiu   +2 more
exaly   +6 more sources

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation [PDF]

International Journal of Molecular Sciences, 2022
The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the endosomes (IRAP). They have also been entrusted with other, although less defined, functions such as the regulation of the angiotensin system and blood pressure.
Silvana Caristi, Alessandro Paiardini, Rosa Sorrentino   +2 more
exaly   +3 more sources