Results 21 to 30 of about 2,212 (246)
Insights into the regulatory role of RNA methylation modifications in glioma
Journal of Translational Medicine, 2023 Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial contributors to the development and progression of gliomas.
Shengrong Long +12 more
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The functions of N6-methyladenosine modification in lncRNAs
Genes and Diseases, 2020 Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most ...
Rong-Zhang He, Jing Jiang, Di-Xian Luo
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Functional roles of ADP-ribosylation writers, readers and erasers
Frontiers in Cell and Developmental Biology, 2022 ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers.
Ping Li +4 more
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Research progress on mRNA methylation and diseases [PDF]
Jichu yixue yu linchuang, 2021 mRNA methylation modification, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A), etc., represents more than 60% of all mRNA modifications and varies distribution on mRNA.
LI Ran, HAO Yan-lei
doaj
m6A: An Emerging Role in Programmed Cell Death
Frontiers in Cell and Developmental Biology, 2022 Programmed cell death is an active extinction process, including autophagy, ferroptosis, pyroptosis, apoptosis, and necroptosis. m6A is a reversible RNA modification which undergoes methylation under the action of methylases (writers), and is ...
Fajuan Tang +9 more
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Eraser Lattices and Semantic Contents: An Exploration of the Semantic Contents in Order Relations between Erasers [PDF]
, 2009 A novel way to define Quantum like measurements for text is through transformations called Selective Erasers. When applied to text, an Eraser acts like a filter and preserves part of the information of the document (tokens surrounding a central term) and ...
van Rijsbergen, C. J. +2 more
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Global profiling of regulatory elements in the histone benzoylation pathway
Nature Communications, 2022 Lysine benzoylation (Kbz) is a recently discovered histone modification. Here, the authors characterize writers, erasers and readers of histone Kbz in S. cerevisiae and identify non-histone proteins bearing Kbz, laying foundations to dissect the roles of
Duo Wang +8 more
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Rubbing Out Leukemia Stem Cells by Erasing the Eraser [PDF]
Cell Stem Cell, 2020 In this issue of Cell Stem Cell, Shen et al. (2020) and Wang et al. (2020) independently identify the essential function of m6A demethylase ALKBH5 in maintaining myeloid leukemia stem cells. These studies expand the regulators of the epitranscriptome that are required for acute myeloid leukemia (AML) development.
Yuanming, Cheng +2 more
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Role of m6A writers, erasers and readers in cancer
Experimental Hematology & Oncology, 2022 The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers.
Zhen Fang +6 more
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Identification of SIRT3 as an eraser of H4K16la
iScience, 2023 Summary: Lysine lactylation (Kla) is a novel histone post-translational modification discovered in late 2019. Later, HDAC1-3, were identified as the robust Kla erasers.
Zhuming Fan +6 more
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