Results 111 to 120 of about 95,906 (268)

Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities

Advanced Science, Volume 12, Issue 46, December 11, 2025.
The tongue's anterior epithelium is maintained by region‐specific stem/progenitor cells, yet in vitro models are limited. Long‐term expanding organoids are developed from adult mouse anterior tongue that retain region‐specific identity, cellular diversity, and gene regulatory features. These organoids differentiate into keratinocytes, Merkel‐like cells,
Seok‐Young Kim, Laurens H. G. Verweij, Lin Lin, Johan H. van Es, Jay Slack, Chris Winkel, Tito Candelli, Philip Lijnzaad, Thanasis Margaritis, Gerben E. Breimer, Karin Sanders, Marc van de Wetering, Hans Clevers   +12 more
wiley   +1 more source

Prognostic Implications of SMARCA4, ARID1A, and Other BAF Mutations in Non‐Small Cell Lung Cancer

Cancer Medicine, Volume 14, Issue 24, December 2025.
ABSTRACT Background and Methods Non‐small cell lung cancer (NSCLC) outcomes have improved remarkably with the widespread use of immune checkpoint inhibitors and small molecule inhibitors targeting driver mutations. Nevertheless, many patients continue to experience suboptimal outcomes. The prevalence of mutations in the BAF (BRG1/BRM‐associated factor)
Alexis Khalil, Michael P. Collins, Alfonso Quintás‐Cardama   +2 more
wiley   +1 more source

Investigation of PM2.5-induced carcinogenic effects through mediation of ErbB family based on DNA methylation and transcriptomics analysis by a lung-mimicking microfluidic platform

, 2022
Lulu Zheng, Yuwen Wang, Yule Zhang, Zong‐Tao Chai, Sixiu Liu, Bo Wang, Bo Dai, Dawei Zhang   +7 more
openalex   +1 more source

The Single Transmembrane Domains of ErbB Receptors Self-associate in Cell Membranes [PDF]

, 2002
Jeannine M. Mendrola, Mitchell B. Berger, Megan C. King, Mark A. Lemmon   +3 more
openalex   +1 more source

TMEM106A as a Macrophage‐Associated Biomarker of Prognosis in IDH‐Wildtype Glioma: Integrative Multi‐Omics and Spatial Analyses

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Introduction Gliomas remain aggressive despite current therapies, highlighting the urgent need for new biomarkers and targets. Transmembrane protein 106A (TMEM106A), implicated as a tumor suppressor in various cancers, has an unclear role in gliomas. We hypothesized that TMEM106A expression associates with tumor aggressiveness and may serve as
Wen‐Shin Song, Pei‐Chi Chang, Dueng‐Yuan Hueng, Yao‐Feng Li   +3 more
wiley   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

iScience
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr   +10 more
doaj   +1 more source

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

BMC Cancer, 2012
Background Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases.
Hiscox Stephen, Baruha Bedanta, Smith Chris, Bellerby Rebecca, Goddard Lindy, Jordan Nicola, Poghosyan Zaruhi, Nicholson Robert I, Barrett-Lee Peter, Gee Julia   +9 more
doaj   +1 more source

Usefulness of DNA ploidy, AgNORs, PCNA and c-erbB-2 as predictors of prognosis in patients with renal cell carcinoma [PDF]

, 1997
腎細胞癌71例について核DNA ploidy, AgNOR, PCNA, c-erbB-2を測定した.腎細胞癌全体では核DNA ploidy, AgNOR, PCNA, c-erbB-2はいずれも予後予測因子として有用であることが示唆され, grade 2症例においてもPCNAとc-erbB-2は予後予測因子として有用であることが示唆されたSeventy one patients with renal cell carcinomas were examined for a variety of ...
出口, 隆, 前田, 真一, 河田, 幸道, 玉木, 正義   +3 more
core  

Increased activation of ErbB and NFκB signalling pathways in Darier disease affected skin

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Nancy Ernst, Ralf J. Ludwig, Artem Vorobyev   +2 more
wiley   +1 more source