Results 91 to 100 of about 56,526 (222)
Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium
Oncology Reports, 2007 Overexpression of the erbB-1 (EGFR, epidermal growth factor receptor) and erbB-2 (HER2/neu) proteins contributes to the aggressive behavior of malignant tumors originating from the endometrium. We currently examined whether the trend of these proteins to overexpression is a direct effect of their gene transcriptional activities.
Magdalena, Brys +3 more
openaire +3 more sources
乳腺浸润性导管癌c-erbB-2的表达与淋巴结转移和肿瘤细胞分裂能力的关系
Zhongguo shiyan zhenduanxue, 2005 目的探讨乳腺浸润性导管癌中c-erbB-2与肿瘤生物学特性的关系。方法应用免疫组化SP方法对检测乳腺浸润性导管癌c-erbB-2的表达情况极其淋巴结转移和癌细胞分裂能力的相关性。结果c-erbB-2阳性表达主要分布在肿瘤细胞的胞膜上;随着c-erbB-2表达强度的降低,肿瘤淋巴结转移率呈减少的趋势;肿瘤组织中细胞的核分裂数目随着c-erbB-2的表达强度增加而增多。结论c-erbB-2是乳腺癌细胞增殖、转移能力和预后判定的参考指标。
王勇 +5 more
doaj
Computational results for ErbB-3-partner systems.
, 2015 (a) to (f), Respective backbone RMSD curves of ErbB-3—WT, ErbB-3—L858R, ErbB-3—L858R_T790M, ErbB-3—c-Met, ErbB-3—ErbB-2 and ErbB-3—IGF-1R systems, in the 2-ns production MD simulations.
Victor H. F. Lee (741519) +4 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dentate gyrus subgranular cell zone (SGZ) of 5×FAD mice was measured using ...
Weiqi Sun +25 more
wiley +1 more source
ErbB Targeted Therapy in Endometrial Cancer
, 2015 The potential role of ErbB receptors (especially EGFR and ErbB-2) as targets for cancer therapy has been investigated for over 30 years. Anti-ErbB monoclonal antibodies (MoAbs) bind to the extracellular domain of EGFR or ErbB-2 and prevent ligand binding
Adonakis G +3 more
core +2 more sources
c-erbB-2 Oncoprotein Content in Gastric Cancer and in Adjacent Mucosa
The International Journal of Biological Markers, 2000 The aim of this study was to evaluate, by means of an immunoenzymatic assay, the membranous and cytosolic c-erbB-2 oncoprotein contents in primary tumors and in adjacent mucosa from gastric cancer patients.
I. García +6 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2011 Maspin is a unique member of the serpin family involved in regulation of cell migration, apoptosis and angiogenesis in breast and prostate cancers. In this study maspin expression in comparison with c-erbB-2 (HER2/neu) oncogene expression and microvessel
Izabela Berdowska +2 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Somatostatin receptor 2 is expressed in nasopharyngeal carcinoma (NPC). We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (SSTR2) gene expression in EBV‐positive and in EBV‐negative NPC correlated with genomic alterations and an inflamed microenvironment.
Dara Bracken‐Clarke +20 more
wiley +1 more source
ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner
, 1998 The different epidermal growth factor (EGF)-related peptides elicit a diverse array of biological responses as the result of their ability to activate distinct subsets of ErbB receptor dimers, leading to the recruitment of different intracellular ...
Graus-Porta, Diana +5 more
core +1 more source
Limited Prognostic Value of c-erbB-2 Compared to uPA and PAI-1 in Primary Breast Carcinoma
The International Journal of Biological Markers, 2003 In a retrospective study of 488 women with primary breast cancer, after a median follow-up of 10 years, we sought interactions between disease-free survival (DFS) and overall survival (OS) and tumor antigen levels of two components of the plasminogen ...
C. Bouchet +4 more
doaj +1 more source