Results 81 to 90 of about 46,899 (191)

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source

Structure-function analysis of nucleolin and ErbB receptors interactions.

PLoS ONE, 2009
BackgroundThe ErbB receptor tyrosine kinases and nucleolin are major contributors to malignant transformation. Recently we have found that cell-surface ErbB receptors interact with nucleolin via their cytoplasmic tail.
Keren Farin, Ayelet Di Segni, Adam Mor, Ronit Pinkas-Kramarski   +3 more
doaj   +1 more source

Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists

iScience
Summary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović, Jan P. Wintgens, Yuxin Wu, Ben Brankatschk, Sascha Menninger, Carsten Degenhart, Niels Jensen, Sven P. Wichert, Bert Klebl, Moritz J. Rossner, Michael C. Wehr   +10 more
doaj   +1 more source

Prognostic impact of p53, c-erbB-2 and epidermal growth factor receptor on head and neck carcinoma

São Paulo Medical Journal
CONTEXT: p53, c-erbB-2 and epidermal growth factor receptor (EGFR) are cancer-related proteins that are usually expressed in head and neck squamous cell carcinoma (SCC). Their prognostic value remains controversial.
Orlando Parise Junior, Leda Viegas Carvalho, Roberto Elias Villela Miguel, Luiz Paulo Kowalski   +3 more
doaj   +1 more source

erbB 基因表达与乳腺癌发生的相关关系

Zhongshan Daxue xuebao. Yixue kexue ban, 1998
目的: 研究 c -erbB-2, c-erbB-4 原癌基因过度表达与乳腺癌发生及其病理参数的相关关系。方法: 对 122 例乳腺疾病石蜡切块,其 中 80 例乳腺癌, 16 例乳腺纤维腺瘤, 9 例乳腺纤维囊性病, 17 例乳腺癌转移淋巴结均采用免疫组化( LSAB 法)结合计算机图象分析研究原癌 基因产物 c-erbB-2, c-erbB-4的表达情况。结果: c-erbB-2 在乳腺癌中存在过度表达, P
doaj  

Assessment of staging, prognosis and mortality of colorectal cancer by tumor markers: receptor erbB-2 and cadherins

Acta Cirúrgica Brasileira, 2005
PURPOSE: To evaluate the prognostic significance and correlation with staging and degree of cell differentiation of the tumoral expression of the proteins c-erbB-2 and E-cadherin, in patients with colorectal adenocarcinoma.
Jesus Eliane C., Matos Delcio, Artigiani Ricardo, Waitzberg Angela F.L., Goldenberg Alberto, Saad Sarhan Sydney   +5 more
doaj  

C－erbB－2表达对乳腺浸润性导管癌预后的预测

Zhongshan Daxue xuebao. Yixue kexue ban, 1996
应用单克隆抗体Ｃ－ｅｒｂＢ－２肿瘤蛋白及免疫组化（ＬＳＡＢ）法，对８４例乳腺浸润性导管癌作Ｃ－ｅｒｂＢ－２癌基因蛋白产物表达（简称Ｃ－ｅｒｂＢ－２表达）检测并与随诊资料进行比较分析，结果（１）Ｃ－ｅｒｂＢ－２在本组病例的表达率为５５．９％（４７／８４）。（２）Ｃ－ｅｒｂＢ－２表达与肿瘤的ＴＮＭ分期、复发／远必转移、５ａ生存率无相关性（Ｐ＞０．０５）、而仅与腋淋巴结转移状况和２ａ死亡率有关（Ｐ＜０．００５及Ｐ＜０．０５）。（３）有／无淋巴结转移病例的Ｃ－ｅｒｂＢ－２表达与患者的预后均无关（Ｐ＞０．７５ ...
doaj  

ErbB [PDF]

, 2019
openaire   +1 more source

An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis. [PDF]

Cell Commun Signal
Zuo W, Luo S, Qin H, Wong KH, Siu SWI, Tashima AK, Assaraf YG, Kwok HF.   +7 more
europepmc   +1 more source

Maspin Modulates Malignant Phenotypes Depending on Subcellular Localization in Pancreatic Ductal Adenocarcinoma Cell Lines. [PDF]

Cancers (Basel)
Mochida H, Sakabe T, Shingu T, Makishima K, Umekita Y.   +4 more
europepmc   +1 more source