Results 101 to 110 of about 56,526 (222)

Interactions Between E3 Ubiquitin Ligases and Deubiquitinases in AKT Regulation: Implications in Skeletal Muscle Homeostasis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT AKT (protein kinase B, PKB) coordinates the balance between anabolic and catabolic signaling in skeletal muscle through distinct ubiquitin chain types. Some E3 ubiquitin ligases (E3s) and deubiquitinases (DUBs) form stable binary complexes via non‐catalytic interfaces, adding a regulatory layer unavailable to either enzyme alone.
Rajesh Dabur
wiley   +1 more source

Negative Prognostic Impact of the Coexpression of Epidermal Growth Factor Receptor and c-erbB-2 in Locally Advanced Cervical Cancer

, 2009
Objective: The objective was to determine the impact of the coexpression of epidermal growth factor receptor (EGFR) and tumor marker c-erbB-2 on disease-free survival (DFS) and pelvic relapse-free survival (PRFS) in patients with locally advanced ...
Alonso, Lorenzo, Ballestín Carcavilla, Claudio, Alba, Emilio, De-la-Cruz, Javier, Mendiola Fernández, Dionisio César, García-Martín, Rosa, Pérez-Regadera Gómez, José Fermín, Lora Pablos, David, Sánchez-Muñoz, Alfonso, Lanzós González, Eduardo   +9 more
core   +1 more source

S100 Calcium‐Binding Protein 16 (S100A16) Promotes Hepatic Stellate Cell Activation Via Erb‐B2 Receptor Tyrosine Kinase 2 (ERBB2)‐mediated Glycolysis to Facilitate Liver Fibrosis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Hepatic stellate cell (HSC) activation is a key mediator in hepatic fibrosis, with glycolysis serving a key regulatory function. S100 calcium‐binding protein 16 (S100A16) has been associated with various pathologies; however, its function and underlying mechanisms in liver fibrosis remains elusive.
Shiyu Ou, Xiaoling Tang, Juan Liu, Rong Ouyang, Shijiang Huang, Shuwen Weng, Jinping Qin, Dingheng Liang, Ling Du, Zhongzhuan Li   +9 more
wiley   +1 more source

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source

Type I tyrosine-kinase receptors (erbB-1, erbB-3 and erbB-4) and Heregulin in experimental models of mammary carcinogenesis [PDF]

, 1998
La alta incidencia de cáncer de mama ha creado la necesidad de comprender elfuncionamiento de las vias regulatorias de la glándula mamaria. Las alteraciones en laexpresión y vias de señalización de los factores de crecimiento parecen críticas en ...
Balañá, María Eugenia
core   +2 more sources

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

Personality correlates of P53, c-erbB-2, BRCA1 protein expression in breast cancer patients

, 2004
In this work, the associations between personality trait and gene protein expressions were evaluated in seventy women with breast cancer. The personality traits of these patients were examined with the Eysenck Personality Questionnaire (EPQ) before ...
W. J. Lin, J. P. Liu, Y. Liu
core   +1 more source

Discovery of Potent EGFR Inhibitors for Del19 and L858R/T790M Mutants Through Structure‐Based Virtual Screening and Biological Evaluation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
XJ2‐2 overcomes NSCLC by blocking EGFR‑driven AKT/ERK cascades. ABSTRACT Epidermal growth factor receptor (EGFR) mutation‐mediated drug resistance represents a major clinical challenge in the treatment of non‐small cell lung cancer (NSCLC). In this study, the lead compound XJ2‐2 was identified through structure‐based virtual screening.
Ting Xu, Yuchen Zhao, Mengfei Chen, Lijuan Zuo, Hanshuang Cai, Yuguo Liu, Chuanfeng Liu, Jing Shi   +7 more
wiley   +1 more source