Results 171 to 180 of about 57,515 (223)

HER2-Mutant Non-Small Cell Lung Cancer Podcast: Knowledge Is Power. [PDF]

Target Oncol
Subbiah V, Dietrich M, Le X.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Expression of ErbB-1 and ErbB-2 in meningioma

Journal of Clinical Neuroscience, 2010
Meningiomas are benign intracranial tumours treated by neurosurgical resection. Residual or recurrent tumour may be treated with radiotherapy. Effective molecular therapy for residual and recurrent meningiomas is currently unavailable. We tested meningiomas for In-ErbB-1 and ErbB-2, and the levels were compared to normal brain, peripheral nerve ...
Agadha, Wickremesekera, Christopher M, Hovens, Andrew H, Kaye   +2 more
openaire   +2 more sources

Untangling the ErbB Signalling Network

Nature Reviews Molecular Cell Biology, 2001
When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over ...
Yosef Yarden, Mark X Sliwkowski, M X Sliwkowski   +2 more
exaly   +3 more sources

The deaf and the dumb: the biology of ErbB-2 and ErbB-3

Experimental Cell Research, 2003
ErbB-2 (also called HER2/neu) and ErbB-3 are closely related to the epidermal growth factor receptor (EGFR/ErbB-1), but unlike EGFR, ErbB-2 is a ligandless receptor, whereas ErbB-3 lacks tyrosine kinase activity. Hence, both ErbB-2 and ErbB-3 are active only in the context of ErbB heterodimers, and ErbB-2.
Ami, Citri, Kochupurakkal Bose, Skaria, Yosef, Yarden   +2 more
openaire   +2 more sources

ErbBs in lung cancer

Experimental Cell Research, 2009
Lung cancer remains the leading cause of cancer deaths worldwide, and advanced stage disease is largely refractory to conventional chemotherapy. Thus, there is an important need for alternative treatment strategies, and the ErbB proteins have emerged as potentially important therapeutic drug targets in this setting, apparently reflecting a state of ...
Sreenath V, Sharma, Jeffrey, Settleman
openaire   +2 more sources

Epiregulin Binds to Epidermal Growth Factor Receptor and ErbB-4 and Induces Tryosine Phosphorylation of Epidermal Growth Factor Receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]

Oncogene, 1997
Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
T Komurasaki, Shigeo Morimoto, H Toyoda
exaly   +3 more sources

Dominance of ErbB-1 Heterodimers in Lung Epithelial Cells Overexpressing ErbB-2: Both ErbB-1 and ErbB-2 Contribute Significantly to Tumorigenicity

American Journal of Respiratory Cell and Molecular Biology, 1999
Abstract This article examines differential expression and heterodimer formation of ErbB family members in tumorigenic and nontumorigenic human bronchial epithelial cells (HBECs). This cell system was developed previously as a model for lung adenocarcinoma by overexpression of c-erbB-2 in nontumorigenic, T antigen–immortalized HBECs ...
A M, Fernandes, A W, Hamburger, B I, Gerwin   +2 more
openaire   +2 more sources

ErbBs in mammary development

Experimental Cell Research, 2003
Members of the ErbB (epidermal growth factor receptor) family of receptor tyrosine kinases are important in etiology of human mammary carcinoma, and are rational targets for cancer therapy. The frequent selection of ErbB2/HER2/Neu, and, less often, the epidermal growth factor receptor, and ErbB3 for overexpression in breast cancer implies that these ...
openaire   +2 more sources

ErbB‐3 and ErbB‐4 Expression in the Mouse Olfactory System^a

Annals of the New York Academy of Sciences, 1998
ABSTRACT: The interplay between neuregulins and the ErbB receptor family has a pivotal role in the development of several tissues, including the nervous system, and is maintained in the adult olfactory system where extensive plasticity and neurogenesis are retained.
PERROTEAU, Isabelle, OBERTO M, IERACI A, BOVOLIN, Patrizia, FASOLO, Aldo   +4 more
openaire   +3 more sources