Results 171 to 180 of about 56,526 (222)
Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines
Cancer Immunology, Immunotherapy, 2002 The tumour antigen ErbB-2 belongs to the epidermal growth factor receptor family. Numerous studies have shown that ErbB-2 is overexpressed in many cancers and it is prognostically important in a subset of malignancies. It is well recognised that this receptor has many characteristics that make it an excellent target for tumour-specific immunotherapy ...
Robyn Lynne Ward
exaly +7 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Expression of ErbB-1 and ErbB-2 in meningioma
Journal of Clinical Neuroscience, 2010Meningiomas are benign intracranial tumours treated by neurosurgical resection. Residual or recurrent tumour may be treated with radiotherapy. Effective molecular therapy for residual and recurrent meningiomas is currently unavailable. We tested meningiomas for In-ErbB-1 and ErbB-2, and the levels were compared to normal brain, peripheral nerve ...
Agadha, Wickremesekera +2 more
openaire +2 more sources
The deaf and the dumb: the biology of ErbB-2 and ErbB-3
Experimental Cell Research, 2003ErbB-2 (also called HER2/neu) and ErbB-3 are closely related to the epidermal growth factor receptor (EGFR/ErbB-1), but unlike EGFR, ErbB-2 is a ligandless receptor, whereas ErbB-3 lacks tyrosine kinase activity. Hence, both ErbB-2 and ErbB-3 are active only in the context of ErbB heterodimers, and ErbB-2.
Ami, Citri +2 more
openaire +2 more sources
Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]
Oncogene, 1997 Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
Toshi Komurasaki, T Komurasaki
exaly +3 more sources
The Role of ErbB Receptors in Infection [PDF]
Trends in Microbiology, 2017 Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Mahvash Tavassoli +2 more
exaly +5 more sources
Experimental Cell Research, 2009
Lung cancer remains the leading cause of cancer deaths worldwide, and advanced stage disease is largely refractory to conventional chemotherapy. Thus, there is an important need for alternative treatment strategies, and the ErbB proteins have emerged as potentially important therapeutic drug targets in this setting, apparently reflecting a state of ...
Sreenath V, Sharma, Jeffrey, Settleman
openaire +2 more sources
Lung cancer remains the leading cause of cancer deaths worldwide, and advanced stage disease is largely refractory to conventional chemotherapy. Thus, there is an important need for alternative treatment strategies, and the ErbB proteins have emerged as potentially important therapeutic drug targets in this setting, apparently reflecting a state of ...
Sreenath V, Sharma, Jeffrey, Settleman
openaire +2 more sources
American Journal of Respiratory Cell and Molecular Biology, 1999
Abstract This article examines differential expression and heterodimer formation of ErbB family members in tumorigenic and nontumorigenic human bronchial epithelial cells (HBECs). This cell system was developed previously as a model for lung adenocarcinoma by overexpression of c-erbB-2 in nontumorigenic, T antigen–immortalized HBECs ...
A M, Fernandes +2 more
openaire +2 more sources
Abstract This article examines differential expression and heterodimer formation of ErbB family members in tumorigenic and nontumorigenic human bronchial epithelial cells (HBECs). This cell system was developed previously as a model for lung adenocarcinoma by overexpression of c-erbB-2 in nontumorigenic, T antigen–immortalized HBECs ...
A M, Fernandes +2 more
openaire +2 more sources
Experimental Cell Research, 2003
Members of the ErbB (epidermal growth factor receptor) family of receptor tyrosine kinases are important in etiology of human mammary carcinoma, and are rational targets for cancer therapy. The frequent selection of ErbB2/HER2/Neu, and, less often, the epidermal growth factor receptor, and ErbB3 for overexpression in breast cancer implies that these ...
openaire +2 more sources
Members of the ErbB (epidermal growth factor receptor) family of receptor tyrosine kinases are important in etiology of human mammary carcinoma, and are rational targets for cancer therapy. The frequent selection of ErbB2/HER2/Neu, and, less often, the epidermal growth factor receptor, and ErbB3 for overexpression in breast cancer implies that these ...
openaire +2 more sources
Science Signaling, 2000
Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
openaire +2 more sources
Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
openaire +2 more sources