Results 181 to 190 of about 56,526 (222)

Targeting ErbB receptor signaling: A pan-ErbB approach to cancer

Molecular Cancer Therapeutics, 2004
Abstract The ErbB receptors are localized to the cell membrane where they are activated by ligand to trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB-mediated signaling confers a growth advantage, resulting in cellular transformation and increased metastatic potential.
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Untangling the ErbB signalling network

Nature Reviews Molecular Cell Biology, 2001
When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over ...
Y, Yarden, M X, Sliwkowski
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ErbB Targeted Drugs and Angiogenesis

Current Vascular Pharmacology, 2010
Members of the ErbB receptor tyrosine kinase family are central regulators of several normal as well as tumor cell functions. A number of therapeutic compounds such as small molecular weight tyrosine kinase inhibitors and monoclonal antibodies have been developed to inhibit ErbB signaling in cancer.
Erika, Iivanainen, Klaus, Elenius
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ErbB Receptors and Cancer

2017
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
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ErbB receptors and their ligands in the breast

Expert Reviews in Molecular Medicine, 2006
ErbB receptor tyrosine kinases are membrane-bound receptors that possess intrinsic, ligand-activated, tyrosine kinase activity. Binding of growth factors to these receptors induces the formation of ErbB homo- and heterodimers and initiates a signalling cascade that traverses the cytoplasm to communicate with the nucleus and the cytoskeleton. The effect
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Targeting ERBB Receptors in Cancer

2007
Tyrosine kinases are a large and diverse family of proteins found only in metazoans. The ERBB family, which encompasses subgroup I of the receptor tyrosine kinase (RTK) superfamily, has four members: epidermal growth factor receptor (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4.
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Cytohesins are cytoplasmic ErbB receptor activators.

Cell, 2010
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors.
Bill, A., Schmitz, A., Albertoni, B., Song, J., Heukamp, L., Walrafen, D., Thorwirth, F., Verveer, P., Zimmer, S., Meffert, L., Schreiber, A., Chatterjee, S., Thomas, R., Ullrich, R., Lang, T., Famulok, M.   +15 more
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ErbB family

British Journal of Pharmacology, 2006
S P H Alexander, A Mathie, J A Peters
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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

EMBO Journal, 1997
Roger R Beerli, R R Beerli, D Graus-Porta   +2 more
exaly  

Role of Neuregulin-1/ErbB Signaling in Cardiovascular Physiology and Disease

Circulation, 2007
Gilles de Keulenaer, Katrien Lemmens
exaly