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Science Signaling, 2000
Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
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Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
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Targeting ErbB receptor signaling: A pan-ErbB approach to cancer
Molecular Cancer Therapeutics, 2004Abstract The ErbB receptors are localized to the cell membrane where they are activated by ligand to trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB-mediated signaling confers a growth advantage, resulting in cellular transformation and increased metastatic potential.
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ErbB Targeted Drugs and Angiogenesis
Current Vascular Pharmacology, 2010Members of the ErbB receptor tyrosine kinase family are central regulators of several normal as well as tumor cell functions. A number of therapeutic compounds such as small molecular weight tyrosine kinase inhibitors and monoclonal antibodies have been developed to inhibit ErbB signaling in cancer.
Erika, Iivanainen, Klaus, Elenius
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2017
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
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The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
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ErbB receptors and their ligands in the breast
Expert Reviews in Molecular Medicine, 2006ErbB receptor tyrosine kinases are membrane-bound receptors that possess intrinsic, ligand-activated, tyrosine kinase activity. Binding of growth factors to these receptors induces the formation of ErbB homo- and heterodimers and initiates a signalling cascade that traverses the cytoplasm to communicate with the nucleus and the cytoskeleton. The effect
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Targeting ERBB Receptors in Cancer
2007Tyrosine kinases are a large and diverse family of proteins found only in metazoans. The ERBB family, which encompasses subgroup I of the receptor tyrosine kinase (RTK) superfamily, has four members: epidermal growth factor receptor (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4.
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Current opinion in investigational drugs (London, England : 2000), 2004
Drugs for specific molecular targets have generated a great deal of excitement for their potential in cancer treatment, particularly with respect to our molecular understanding of cancer in recent years. The clinical utility of antibodies and small molecule kinase inhibitors has been demonstrated.
Jennifer D, Black +4 more
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Drugs for specific molecular targets have generated a great deal of excitement for their potential in cancer treatment, particularly with respect to our molecular understanding of cancer in recent years. The clinical utility of antibodies and small molecule kinase inhibitors has been demonstrated.
Jennifer D, Black +4 more
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Insights on ErbB Glycosylation – Contributions to Precision Oncology
Trends in Cancer, 2022Henrique O Duarte +2 more
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