Results 131 to 140 of about 2,336,646 (291)
Folia Histochemica et Cytobiologica, 2010 The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz +2 more
doaj +1 more source
An ultrasensitive sorting mechanism for EGF receptor endocytosis [PDF]
, 2008 Background The EGF receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling ...
Dikic, Ivan +4 more
core +2 more sources
Pediatric Discovery, EarlyView.ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang +4 more
wiley +1 more source
Small, EarlyView.A. Synthetic biology and biomaterials have emerged as tools to study and facilitate the treatment of solid tumors wi‐th chimeric antigen receptor‐CAR‐T cells. These strategies aim to resist the tumor microenvironment‐TME that presents cellular, biochemical, and mechanical immunosuppressive signals that hinder CAR‐T efficacy. B.
Grazia Marsico +2 more
wiley +1 more source
ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor [PDF]
, 2018 In this work, we have analyzed the expression of different members of the ErbB family in human samples of testicular germ cell tumors (GCTs). We observed expression of ErbB1 or ErbB2 in different tumor subtypes, but we also found high expression of ErbB3
Casanovas i Casanovas, Oriol +13 more
core +1 more source
Nationwide Real‐World Usage of Blood‐Based (Liquid) Biomarker Testing in Japan
Cancer Science, EarlyView.This database analysis explores how liquid biopsy testing is integrated into clinical practice in Japan. ABSTRACT Despite the advances in precision oncology through biomarker testing, not all patients are able to benefit from treatment decisions guided by tissue‐based testing like comprehensive genomic profiling (CGP).
Yasushi Yatabe +4 more
wiley +1 more source
Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]
Front Oncol, 2023 Breitenecker K +10 more
europepmc +1 more source
Nano‐Mediated Fluorescence Switching for Epidermal Growth Factor Receptor Detection
Cell Proliferation, EarlyView.This study presents Cy3‐AptEGFR@BPNSs, a novel nano‐detector for real‐time, visual monitoring of EGFR expression in cancer cells. Addressing the limitations of current methods, this detector utilises fluorescence quenching/recovery, providing high specificity and sensitivity, with fluorescence intensity proportional to EGFR levels.
Xin Fu +11 more
wiley +1 more source
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]
J Mammary Gland Biol Neoplasia, 2023 Morato A, Accornero P, Hovey RC.
europepmc +1 more source
Tumour Cell Size Control and Its Impact on Tumour Cell Function
Cell Proliferation, EarlyView.The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley +1 more source