Cancer Medicine, Volume 14, Issue 8, April 2025.ABSTRACT Introduction Human epidermal growth factor receptor 2‐positive (HER2‐positive) breast cancer (BC) is a heterogeneous disease. In this study, we hypothesised that the degree of HER2 oncogenic activity, and hence response to anti‐HER2 therapy is translated into a morphological signature that can be of prognostic/predictive value.
N. M. Atallah +6 more
wiley +1 more source
Inhibition of the erbB-2 Tyrosine Kinase Receptor in Breast Cancer Cells by Phosphoromonothioate and Phosphorodithioate Antisense Oligonucleotides [PDF]
, 1996 James P. Vaughn +6 more
openalex +1 more source
Uterine Serous Carcinoma Arising From Endometrial Polyp: A Case Report
Gynecology Obstetrics & Reproductive Medicine, 2009 Serous carcinoma is the prototype of type II endometrial carcinoma. A 71-year-old woman who had history of smoking, diabetes mellitus and hypertension admitted to the hospital with postmenopausal uterine bleeding.
Sibel Bektaş +4 more
doaj
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers [PDF]
, 1998 Anne E.G. Lenferink
openalex +1 more source
International Journal of Eating Disorders, Volume 58, Issue 4, Page 756-769, April 2025.ABSTRACT Objective Anorexia nervosa (AN) is an eating disorder characterized by severe weight loss and associated with hyperactivity and circadian rhythm disruption. However, the cellular basis of circadian rhythm disruption is poorly understood. Glial cells in the suprachiasmatic nucleus (SCN), the principal circadian pacemaker, are involved in ...
Annelie Zimmermann +11 more
wiley +1 more source
Gene amplification for c-erbB-2, c-myc, epidermal growth factor receptor, int-2, and N-myc measured by quantitative PCR with a multiple competitor template [PDF]
, 1995 Roberta Sestini +7 more
openalex +1 more source
Pancreatic Cancer: Pathogenesis and Clinical Studies
MedComm, Volume 6, Issue 4, April 2025.Although the treatment landscape for cancer has evolved rapidly in recent years, progress has stagnated for pancreatic cancer (PC). PC includes multiple types, but pancreatic ductal adenocarcinoma (PDAC) accounts for >90% of cases. This review focuses on the molecular pathogenesis and different treatments for PDAC, hoping to propose future directions ...
Kexun Zhou +3 more
wiley +1 more source
The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses [PDF]
, 2000 Rolando A.G. Garcia +2 more
openalex +1 more source
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review
British Journal of Pharmacology, Volume 182, Issue 7, Page 1416-1445, April 2025.Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis +16 more
wiley +1 more source
Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia
Journal of Pain Research, 2013 Satoshi Mizobuchi,1* Hirotaka Kanzaki,1–3* Hiroki Omiya,1 Yoshikazu Matsuoka,1 Norihiko Obata,1 Ryuji Kaku,1 Hirochika Nakajima,1 Mamoru Ouchida,2 Kiyoshi Morita11Department of Anesthesiology and Resuscitology, 2Department of Molecular Genetics,
Mizobuchi S +8 more
doaj