Results 41 to 50 of about 1,329 (197)

Sex differences in the work of breathing during exercise are independent of forced vital capacity in healthy adults

Experimental Physiology, EarlyView.
Abstract During exercise, females have a higher work of breathing (ẆB) than males for a given minute ventilation (V̇E$ \dot {V}_{\text {E}}$) ≥ 50–60 L min−1, presumably due to sex differences in airway size. However, on average, males have greater forced vital capacity (FVC) than females, and the confounding effect of FVC on sex differences in ẆB is ...
Gracie O. Grift, Jack R. Dunsford, Jasvir K. Dhaliwal, Paolo B. Dominelli, Yannick Molgat‐Seon   +4 more
wiley   +1 more source

Physical exercise intervention in glycogen storage disease IIIa: Feasibility and multisystem benefits

Experimental Physiology, EarlyView.
Abstract Glycogen storage disease III (GSD‐III) is caused by an inherited deficiency of the glycogen debranching enzyme. Affecting the liver, muscle and heart, GSD‐IIIa is the most common GSD‐III subtype. We evaluated the feasibility and safety of a physical exercise intervention in patients with GSD‐IIIa and its effects at the multisystem level.
Asunción Bustos‐Sellers, Almudena Montalvo‐Pérez, Araceli Boraita, Gonzalo Saco‐Ledo, Lidia B. Alejo, David Barranco‐Gil, Pedro L. Valenzuela, Nerea López‐Maldonado, Roser Ferrer‐Costa, Javier Esparcia‐Estrela, Celia Monteagudo‐López, Tomàs Pinós, Alejando Santos‐Lozano, Alejandro Lucia, Alfredo Santalla   +14 more
wiley   +1 more source

Antioxidant supplementation blunts the proteome response to 3 weeks of sprint interval training preferentially in human type 2 muscle fibres

The Journal of Physiology, EarlyView.
Abstract figure legend Sprint interval training (SIT) is a popular time‐efficient type of endurance training. Healthy young men performed nine SIT sessions (4–6 × 30 s all‐out cycling sprints) over 3 weeks while being supplemented with antioxidants (high doses of vitamins C and E) or placebo. Muscle biopsies taken before and after the first SIT session
Victoria L. Wyckelsma, Marta Murgia, Sigitas Kamandulis, Stefano Gastaldello, Marius Brazaitis, Audrius Snieckus, Nerijus Eimantas, Mati Pääsuke, Sebastian Edman, William Apro, Daniel C. Andersson, Håkan Westerblad, Tomas Venckunas   +12 more
wiley   +1 more source

5-HT receptors: Pharmacology and functional selectivity [PDF]

Serotonin 5-HT receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed throughout the body in nearly every cell and tissue type, with the highest density in cortical layer V of the brain ...
Billac, Gerald B, Cummins, Benjamin R, Nichols, Charles D, Nichols, David E   +3 more
core   +2 more sources

Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms

Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.
ABSTRACT In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades because legislation controlled its recreational use, citing their hallucinogenic and psychotomimetic effects,
Makiath Adebo, Mathilda Bonnet, Ons Laouej, Celine Defaix, Josephine C. McGowan, Florence Butlen‐Ducuing, Denis J. David, Erwan Poupon, Laurent Tritschler, Alain M. Gardier   +9 more
wiley   +1 more source

Solid substrate mediated changes in ergot alkaloid spectra in solid state fermentation system [PDF]

, 1993
Use of different solid substrates resulted in minor alterations in total alkaloid production by #Claviceps purpurea$ 1029c in solid state fermentation system but the changes in the spectra of ergot alkaloids were of significantly higher magnitudes ...
Lonsane, B.K., Raimbault, Maurice, Roussos, Sevastianos, Trejo Hernandez, M.R.   +3 more
core  

N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylarnine Analogues [PDF]

A series of N-benzylated-5-methoxytryptamine analogues was prepared and investigated, with special emphasis on substituents in the meta position of the benzyl group.
Brandt, SD, Elliott, SP, Fiedler, WJ, Halberstadt, AL, Klein, LM, Nichols, DE, Sassano, MF   +6 more
core   +1 more source

Prehabilitation of Patients With Oesophageal Malignancy Undergoing Peri‐Operative Treatment (Pre‐EMPT): Outcomes From a Prospective Controlled Trial

Journal of Surgical Oncology, Volume 131, Issue 8, Page 1508-1520, June 2025.
ABSTRACT Background The Pre‐EMPT study aimed to determine if structured exercise could reduce length of stay, post‐operative complications and improve fitness and health‐related quality of life (HQRL) in patients undergoing neoadjuvant chemotherapy (NAC) and oesophagectomy.
R. Bott, J. Zylstra, W. Knight, G. P. Whyte, A. M. Lane, C. Moss, M. Browning, J. Lagergren, M. Van Hemelrijck, A. R. Davies, the Pre‐EMPT study group including the following co‐authors, J. Gossage, M. Kelly, C. Baker, J. Taylor, O. Rusu, O. Evans, G. Tham, T. Dixon, G. Hallward, C. Taylor, N. Maisey, S. Ngan, A. Lumsden, K. Owczarczyk, A. Qureshi, N. Griffin, A. Jacques, V. Goh, M. Green, H. Deere, F. Chang, U. Mahadeva, B. Gill‐Barman, M. Ong, S. George, J. Dunn, S. Zeki, J. Waters, M. Cominos, T. Sevitt, M. Hill, A. Santa Ollala, K. Beckmann, L. Gervais‐Andre, J. Pate   +45 more
wiley   +1 more source

Correction to “Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids” [PDF]

, 2022
Yongpeng Yao, Chunyan An, Declan Evans, Weiwei Liu, Wei Wang, Guangzheng Wei, Ning Ding, K. N. Houk, Shu‐Shan Gao   +8 more
openalex   +1 more source

Structural Features for Functional Selectivity at Serotonin Receptors [PDF]

, 2013
Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling.
Cherezov, V., Chu, M., Han, G. W., Huang, X.-P., Jiang, Y., Katritch, V., Liu, W., McCorvy, J. D., Roth, B. L., Siu, F. Y., Stevens, R. C., Vardy, E., Wacker, D., Wang, C., Xu, H. E.   +14 more
core   +2 more sources