Results 51 to 60 of about 1,343 (193)

Moderate intermittent hypoxic conditioning to enhance vascular function and cardiorespiratory fitness in the elderly: A randomized controlled trial

Physiological Reports, Volume 13, Issue 19, October 2025.
Abstract Vascular aging involves reduced endothelial function, a key factor in cardiovascular diseases. Intermittent hypoxia may improve endothelial function and cardiorespiratory fitness (CRF), but its effects in elderly individuals, especially in the mid‐term, have not yet been studied.
Hugo Randy, Titouan P. Perrin, Abdallah Ghaith, Dario Kohlbrenner, Patrice Flore, Benoit Champigneulle, Michel Guinot, Stéphane Doutreleau, Julien Brugniaux, Samuel Verges, Mathieu Marillier   +10 more
wiley   +1 more source

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, Volume 17, Issue 8, Page 1283-1293, August 2025.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source

Impaired physical fitness in pediatric inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition, Volume 81, Issue 2, Page 275-285, August 2025.
Abstract Objective There are only a few studies on physical fitness in pediatric inflammatory bowel disease (PIBD). We compared physical fitness in PIBD patients versus healthy controls and analyzed the role of contributing disease‐ and patient‐related factors.
Saija Kantanen, Kati Räsänen, Kaija‐Leena Kolho, Heini Huhtala, Kalle Sipilä, Ilkka Pörsti, Laura Vekara, Eija Piippo‐Savolainen, Timo Lakka, Pekka Arikoski, Pauliina Hiltunen   +10 more
wiley   +1 more source

Pituitary surgery for small prolactinomas as an alternative to treatment with dopamine agonists [PDF]

, 2018
Despite the fact that consensus guidelines recommend long-term dopamine agonist (DA) therapy as a first-line approach to the treatment of small prolactinoma, some patients continue to prefer a primary surgical approach.
Andres, Robert, Babey, Muriel, Sahli, Rahel, Seiler, Rolf, Vajtai, Istvan   +4 more
core  

Repetition‐dependent acute cardiopulmonary responses during intensity‐matched squats in males

Experimental Physiology, Volume 110, Issue 8, Page 1114-1128, 1 August 2025.
Abstract The ‘strength–endurance continuum’ is a key concept in strength training (ST). Although cardiopulmonary responses have seldom been reported in conjunction with ST, this repeated‐measurement study examined acute blood pressure and haemodynamic responses continuously depending on the number of repetitions but without changing the intensity ...
Johannes Lässing, Sonja Hummelmann, Maxi Kramer, Ulrich Laufs, Sven Fikenzer, Roberto Falz   +5 more
wiley   +1 more source

Structural Features for Functional Selectivity at Serotonin Receptors [PDF]

, 2013
Drugs active at G protein-coupled receptors (GPCRs) can differentially modulate either canonical or non-canonical signaling pathways via a phenomenon known as functional selectivity or biased signaling.
Cherezov, V., Chu, M., Han, G. W., Huang, X.-P., Jiang, Y., Katritch, V., Liu, W., McCorvy, J. D., Roth, B. L., Siu, F. Y., Stevens, R. C., Vardy, E., Wacker, D., Wang, C., Xu, H. E.   +14 more
core   +2 more sources

Prehabilitation of Patients With Oesophageal Malignancy Undergoing Peri‐Operative Treatment (Pre‐EMPT): Outcomes From a Prospective Controlled Trial

Journal of Surgical Oncology, Volume 131, Issue 8, Page 1508-1520, June 2025.
ABSTRACT Background The Pre‐EMPT study aimed to determine if structured exercise could reduce length of stay, post‐operative complications and improve fitness and health‐related quality of life (HQRL) in patients undergoing neoadjuvant chemotherapy (NAC) and oesophagectomy.
R. Bott, J. Zylstra, W. Knight, G. P. Whyte, A. M. Lane, C. Moss, M. Browning, J. Lagergren, M. Van Hemelrijck, A. R. Davies, the Pre‐EMPT study group including the following co‐authors, J. Gossage, M. Kelly, C. Baker, J. Taylor, O. Rusu, O. Evans, G. Tham, T. Dixon, G. Hallward, C. Taylor, N. Maisey, S. Ngan, A. Lumsden, K. Owczarczyk, A. Qureshi, N. Griffin, A. Jacques, V. Goh, M. Green, H. Deere, F. Chang, U. Mahadeva, B. Gill‐Barman, M. Ong, S. George, J. Dunn, S. Zeki, J. Waters, M. Cominos, T. Sevitt, M. Hill, A. Santa Ollala, K. Beckmann, L. Gervais‐Andre, J. Pate   +45 more
wiley   +1 more source

Structure and function of serotonin G protein-coupled receptors [PDF]

, 2015
Serotonin receptors are prevalent throughout the nervous system and the periphery, and remain one of the most lucrative and promising drug discovery targets for disorders ranging from migraine headaches to neuropsychiatric disorders such as schizophrenia
McCorvy, John D., Roth, Bryan L.
core   +2 more sources

5-HT2B Receptor-mediated Cardiac Valvulopathy [PDF]

, 2018
5-HT2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic,
Nistala, Pallavi
core   +1 more source

Effects of alkaloid exposure and environment on digestion, nutrient balance, and immune function in beef cattle [PDF]

Fescue toxicosis is a complex condition in cattle caused by the consumption of ergot alkaloids produced by the endophyte (Epichloe coenophiala) that infects tall fescue [Lolium arundinaceum (Schreb.) Darbysh.].
Zeltwanger, Joshua
core   +1 more source