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Dual defense mechanisms from a novel marine fungus <i>Nigrograna chlamydospora</i> sp. nov. B143: antifungal and anti-aflatoxigenic properties against <i>Aspergillus flavus</i>. [PDF]

Front Microbiol
Ou X, Wang Q, Huang S, Li Y, Yang L, Luo Y, Wang S, Liang M, Pan L, Liu B, Yang D.   +10 more
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Ergosterol biosynthesis pathway in Aspergillus fumigatus

Steroids, 2008
The sterol composition of Aspergillus fumigatus for the biosynthesis of ergosterol is of interest since this pathway is the target for many antifungal drugs in clinical use. The sterol composition of this fungal species was analyzed by gas chromatography-mass spectrometry in different strains (susceptible and resistant to azole drugs).
Laura, Alcazar-Fuoli, Emilia, Mellado, Guillermo, Garcia-Effron, Jordi F, Lopez, Joan O, Grimalt, J Manuel, Cuenca-Estrella, Juan L, Rodriguez-Tudela   +6 more
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Outline of the biosynthesis and regulation of ergosterol in yeast

World Journal of Microbiology and Biotechnology, 2019
Sterols are crucial functional components for eukaryotic cell membrane. Due to versatile activities, sterols show wide applications in food and pharmaceutical industries. Ergosterol not only reflects cell growth but also serves as the precursor for manufacturing steroid drugs. To date, the ergosterol biosynthetic pathway in yeast has been reported, and
Jun-Feng Liu, Jun-Jie Xia, Kai-Li Nie, Fang Wang, Li Deng   +4 more
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Control of ergosterol biosynthesis in yeast

Biochemical and Biophysical Research Communications, 1968
Abstract It has been established that the activity of HMG-CoA ∗ reduction to MVA in animal is controlled by bile acids which are presumed to be the end products in cholesterol metabolism ( Fimognari and Rodwell, 1965 ). Similar results were reported with Mycobacterium and Pseudomonas ( Fimognari and Rodwell, 1965a ).
A, Kawaguchi, H, Hatanaka, H, Katsuki
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Ergosterol biosynthesis in Mucor pusillus

Phytochemistry, 1976
Abstract Ergosterol, 22-dihydroergosterol, obtusifoliol and 24-methylene-24,25-dihydrolanosterol, isolated from Mucor pusillus grown in the presence of methionine-[methyl- 2 H 3 ], each contained two deuterium atoms; lanosterol, however, was unlabelled. Ergosterol and 22-dihydroergosterol, isolated from M.
E.Ian Mercer, David J.R. Carrier
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The biosynthesis of ergosterol from isotopic acetate

Archives of Biochemistry and Biophysics, 1952
Abstract In a previously coenzyme A-deficient yeast, which was subsequently enriched, 74–84% of the carbon atoms of ergosterol were derived from acetate. Using these yeast cells and labeled acetate as the precursor, ergosterol of high specific activity can be prepared.
D J, HANAHAN, S J, AL-WAKIL
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The Biosynthesis of Ergosterol

Pesticide Science, 1984
AbstractThe present state of knowledge of ergosterol biosynthesis is reviewed briefly in order to provide a contextual framework for the following papers which deal with its inhibition, the compounds that cause this inhibition, and their mode of action.
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Effect of Temperature on Ergosterol Biosynthesis in Yeast

The Journal of Biochemistry, 1975
Anaerobically grown Saccharomyces cerevisiae was aerated for 7 hr at 20 degrees, 30 degrees, or 40 degrees, in a phosphate buffer containing 2% glucose. At elevated temperature (40 degrees), de novo synthesis of squalene and sterois in the aerated yeast was only 32-35% of that at lower temperature (20 degrees or 30 degrees), and this decrease was ...
I, Shimizu, H, Katsuki
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Transmethylation products as intermediates in ergosterol biosynthesis in yeast

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
Abstract 1. 1. The methylated non-saponifiable products obtained by transmethylation from S-adenosyl- l -methionine have been identified as sterols. 2. 2. At least three sterols possessing the transferred methyl group are observed; one of these is ergosterol. 3. 3.
J R, TURNER, L W, PARKS
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Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida

Microbial Pathogenesis, 2010
Azoles target the ergosterol synthesizing enzyme lanosterol 14alpha-demethylase and are a widely applied class of antifungal agents. Unfortunately azoles are generally fungistatic, and resistance to fluconazole is emerging in several fungal pathogens.
Aijaz, Ahmad, Amber, Khan, Nikhat, Manzoor, Luqman A, Khan   +3 more
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