Results 171 to 180 of about 22,662 (208)
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Inhibitors of Ergosterol Biosynthesis as Antifungal Agents
Current Pharmaceutical Design, 1997Abstract: The rise in the incidence of fungal infections over the past two to three decades, particularly those caused by opportunistic pathogens in immune-compromised patients, has strengthened the need for new antifungal drugs. Up to only 30 years ago the choice of systemically available antimycotics was between two drugs, amphotericin B and 5 ...
D. Sanglard, P.G. Hartman
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Ergosterol Biosynthesis Inhibitors
1991A number of possible biochemical approaches can be adopted in search of new antifungals. Potential targets can be selected that are present in the fungus but not in the host, or present in both organisms but different in their properties and/or affinities for drugs. Another approach might be the study of the mode of action of existing antifungals.
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Biochemical Aspects of Ergosterol Biosynthesis Inhibition
1992The major product of sterol biosynthesis in fungi and some trypanosomes is ergosterol, unlike in mammalian systems which synthesize cholesterol as the major membrane lipid (12, 13). The two sterols differ in a few minor ways: cholesterol has a second double bond (Δ5(6)) in the B ring (Figure 16.1) and has a fully saturated side chain without a methyl ...
Keith Barrett-Bee, Neil Ryder
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Synthesis of 6(α,β)-aminocholestanols as ergosterol biosynthesis inhibitors
Bioorganic & Medicinal Chemistry Letters, 1998delta 7-5-Desaturase catalyses one of the last steps in ergosterol biosynthesis in fungi. Moreover delta 5-unsaturation is necessary for the sparking function. Synthesis of three pairs of C-6 epimeric cholestanol derivatives are described as potential growth inhibitors.
P, Beuchet +4 more
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Overexpression of Ecm22 improves ergosterol biosynthesis inSaccharomyces cerevisiae
Letters in Applied Microbiology, 2018Ergosterol biosynthesis in Saccharomyces cerevisiae is complex and the underlying mechanism of regulation remains unclear. To clarify the influence of transcriptional regulation on the ergosterol content, transcription factor Ecm22 was overexpressed in S. cerevisiae.
S.-Q. Wang +4 more
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Ergosterol Turnover in Yeast: An Interplay between Biosynthesis and Transport
Biochemistry (Moscow), 2019Sterols are important components of biological membranes that determine the physicochemical properties of lipid bilayer and regulate the functioning of membrane proteins. Being insoluble in water, sterols cannot diffuse between the membrane compartments separated by an aqueous phase. For this reason, distribution of sterols across cellular membranes is
S S, Sokolov +3 more
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Ergosterol Biosynthesis in Yeast
The Journal of Biochemistry, 1978Takashi OSUMI +4 more
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Analysis of mathematical model of ergosterol biosynthesis
2014U ovom radu provedena je analiza matematičkog modela biosinteze ergosterola (Alvarez-Vasquez i sur., 2011) korištenjem programskih paketa WR Mathematica 8.0. i CellDesigner 4.3. Analizirani model uključuje reakcije biosinteze ergosterola i sfingolipida, budući da je mnogobrojnim istraživanjima potvrđen sinergijski učinak spomenutih puteva biosinteze ...
Jurinjak Tušek, Ana +1 more
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Fungicidal inhibitors of ergosterol biosynthesis
Biochemical Society Transactions, 1983openaire +2 more sources
Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Genes, 2020Tania Jordá, Sergi Puig
exaly