Results 41 to 50 of about 22,662 (208)
Applied and Environmental MicrobiologyErgosterol is an important component of fungal cell membranes and participates in the regulation of its fluidity, permeability, and material transport. In our study, we found that the ergosterol biosynthesis pathway in Aspergillus oryzae is more complex ...
Xueqin Tian +6 more
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Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
Molecules, 2018 With the goal of obtaining a novel bioactive compound with significant antifungal activity, a series of 1,3,4-thiadiazole derivatives (3a⁻3l) were synthesized and characterized.
Ahmet Çağrı Karaburun +9 more
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Studies on the Biosynthesis of the ergosterol side chain [PDF]
Biochemical Journal, 1969 1. A convenient synthesis of 24-methylene[23,25−3H3]dihydrolanosterol is described. 2. A general anaerobic–aerobic method for the incorporation of sterols into whole yeast cells is also described and illustrated by experiments with 3H-labelled lanosterol. 3. The method was used to convert labelled 24-methylene-dihydrolanosterol into ergosterol, in good
M, Akhtar, M A, Parvez, P F, Hunt
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Journal of Lipid Research, 2022 Cytochrome P450s (P450s) are heme-containing proteins involved in several cellular functions, including biosynthesis of steroidal hormones, detoxification of xenobiotic compounds, among others.
Ana-María González +8 more
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Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad +4 more
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Ergosterol biosynthesis and drug development for Chagas disease [PDF]
Memórias do Instituto Oswaldo Cruz, 2009 This article presents an overview of the currently available drugs nifurtimox (NFX) and benznidazole (BZN) used against Trypanosoma cruzi, the aetiological agent of Chagas disease; herein we discuss their limitations along with potential alternatives with a focus on ergosterol biosynthesis inhibitors (EBI).
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ERGOSTEROL BIOSYNTHESIS: A FUNGAL PATHWAY FOR LIFE ON LAND? [PDF]
Evolution, 2012 Sterols, essential lipids of most eukaryotic cells, ensure important structural and signaling functions. The selection pressure that has led to different dominant sterols in the three eukaryotic kingdoms remains unknown. Here, we investigated the influence of the progression in the different steps of the ergosterol biosynthetic pathway (EBP) on the ...
Dupont, Sébastien +5 more
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StressesErgosterol is a key fungal sterol that is mainly found in the plasma membrane and is responsible for the proper membrane structure, rigidity, permeability and activity of membrane proteins. Ergosterol plays a crucial role in the ability of fungi to adapt
Daniel Eliaš +2 more
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Δ8(9),22-Ergostadiene-3β-ol, an ergosterol precursor accumulated in wild-type and mutants of yeast
Journal of Lipid Research, 1972 Whereas wild-type strains of Saccharomyces cerevisiae can synthesize up to 7% dry weight of ergosterol, a polyene-resistant mutant has been obtained which produces no ergosterol. Instead, a C-28 methyl sterol is produced, and it has been identified as Δ8(
L.W. Parks +3 more
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Effect of Septoria leaf blotch and its control with commercial fungicides, on arbuscular-mycorrhizal-fungal colonization, spore numbers, and morphotype diversity [PDF]
, 2014 Arbuscular-mycorrhizal internal structures (i.e. total root colonization, arbuscules, vesicles) and external structures (i.e. spore density), and Glomeromycota spore morphotypes, were evaluated in wheat severely infected with Mycosphaerella graminicola –
Cabello, Marta Noemí +3 more
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